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Allgemeinbegriff

Inhibitor

Sachbegriff	Inhibitor
Synonym	Hemmstoff
Beziehung	Antagonist (verwandter Begriff) Inhibition (verwandter Begriff)
Themengebiet	Theoretische und Physikalische Chemie Biochemie, Biophysik, Zytologie
Quelle	M Römpp (9.Aufl.)
Datensatztyp	Allgemeinbegriff
GND-Nummer	4027007-5
Datensatz-ID	040270076
Thema in alle anzeigen Charakterisierung von inhibitorischen Synapsen in der Säugernetzhaut Development of covalent DPP8/9 inhibitors Discovery and characterization of Kunitz inhibitors as antivirals against Corona and Influenza viruses From structural insights to small-molecule inhibitors: targeting the SARS-CoV-2 RNA element SL1 High-throughput screening for KRAS-G12D inhibitor combination strategies in murine PDAC models Identification and characterization of novel inhibitors of bacterial AB-type toxins Mechanisms of resistance to BTK inhibitors independent of BTK and PLCG2 mutations Synthese und biologische Evaluierung von Inhibitoren der Carboanhydrase II Systematic Comparison of Histone Deacetylase Inhibitors Manipulating the Expression of Human T-cell Lymphotropic Virus Type 1 Targeting ALC1 for synthetic lethality in cancer : a superior alternative to PARP inhibitors Analyse zur nichtkanonischen Wirkung von Inhibitoren der Transkriptionskontrolle im Harnblasenkarzinom Characterization of novel NEDDylation inhibitors in in vitro models of atherogenesis Characterization of the effect of a GLUT1 inhibitor on macrophages and T cells for modulating the immune response to myocardial infarction Charakterisierung des Immunphänotyps von Urothelkarzinom- Zelllinien sowie Tumor-Zelllinien von Kopf und Hals nach Behandlung mit epigenetischen Inhibitoren Charakterisierung von GISB-284 als Inhibitor von Metallo-β-Lactamasen Computer-based analysis of histone deacetylase 10 and its inhibitor complexes Corrosion inhibitors for bare and PEO-coated Mg alloys Design and Synthesis of FK506 binding protein inhibitors acting as anti-infectives and as molecular glues Development of small molecule inhibitors of the bacterial toxin pneumolysin Duale BRD4 und PLK1 Inhibitoren im Rhabdomyosarkom Experimentelle Untersuchungen zur vermuteten Rolle der Dipeptidyl-Peptidase-IV Inhibitoren als Auslöser akuter Krankheitsausbrüche des bullösen Pemphigoids Identification and characterization of human endogenous proteins and peptides as novel inhibitors for the Bordetella pertussis toxin and related AB-type protein toxins In Silico Design of Novel Inhibitors for Cancer-Related Targets In vitro testing of histone deacetylase inhibitors (HDACi) in combination with temozolomide radio-chemotherapy as a treatment strategy for pediatric high-grade gliomas (pedHGG) Investigation of PINK1 cleavage and trafficking using novel PARL-targeted α-ketoamide-based inhibitors Investigation of Rlig1: from discovery of inhibitors to functional characterization Modulation of the cGAS/STING pathway in various tumor cell lines by a novel HSP90 inhibitor Molecular Mechanisms of Nephroprotection of SGLT2 Inhibitor Molecular modeling and design of selective histone deacetylase 11 (HDAC11) inhibitors Multivalent polymer-peptide conjugates as inhibitors of SARS-CoV-2 New Strategies for Cancer Therapy – Development of Fluorescent Labeling Techniques, Novel Inhibitors and Photoswitchable Probes Pharmacological Studies on TRPC6 Inhibitors Preclinical evaluation of histone deacetylase inhibitors for epigenetic therapy of diffuse large B-cell lymphoma Prospektive Untersuchung von prognostischen Markern des Nierenschadens beim kardiorenalen Syndrom: Erfassung der Auswirkung von SGLT2 Inhibitoren auf Parameter der renalen Kongestion QSAR-guided design and synthesis of novel inhibitors targeting KRAS protein-protein interactions Quantitative mass spectrometry-based (chemo-) proteomics for the characterization of MEP pathway inhibitors Strukturbasiertes Design von Inhibitoren der bakteriellen Pyocyanin-Biosynthese Strukturbasiertes Design, Synthese und Evaluation dual-kovalenter Immunoproteasom- und SARS-CoV-2 Mᵖʳᵒ-Inhibitoren The role of RB and its complex in CDK4/6 inhibitor therapy: Mechanisms of cell cycle regulation and oncolytic virus replication Thrombospondin-1 as inhibitor of the alternative complement pathway in antineutrophil cytoplasmic antibodyassociated vasculitis Untersuchungen zur gezielten Behandlung FLT3-ITD-positiver AML-Zellen mit hohen SKI-Leveln mit verschiedenen Inhibitoren Von peptidischen zu nicht-peptidischen Hemmstoffen der Proproteinconvertase Furin Absolute Behandlungseffekte der primären Endpunkte und der Gesamtmortalität in den kardiovaskulären Endpunktstudien der neuen Antidiabetika: Meta-Analyse digitalisierter Patientendaten Activator and inhibitor interactions and expression during trichome patterning in Arabidopsis thaliana Angiotensin-Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker in Cerebral Arteriogenesis Antineoplastische Wirkung von Inhibitoren der Poly(ADP-ribose)-Polymerase-1 in Kombination mit Inhibitoren der Zellzykluskinasen CDK4 und CDK6 in Ewing-Sarkomzellen Bacterial-Derived Metabolites in the Context of Immune Checkpoint Inhibitor Cancer Therapy Bedeutung der Homologen Rekombination für die Wirkung des dualen PI3K/mTOR-Inhibitors NVP-BEZ235 auf eine kombinierte Behandlung von Kopf-Hals-Tumorzellen mit Cisplatin und Bestrahlung Bekämpfung antibakterieller Resistenz: Entwicklung neuartiger Enzymassays zur Charakterisierung von Inhibitoren der Lipid A-Biosynthese Characterization of PARP inhibitor resistance in patient-derived ovarian cancer cell lines Characterization of the role of the atypical NF-κB inhibitor protein, "IκBNS" in regulatory T cells and its interaction with NF-κB1 Charakterisierung der Rolle von Smad7 bei der Entstehung und Entwicklung des Pankreaskarzinoms Charakterisierung genetischer Aberrationen in T-Zell Neoplasien und Einfluss der epigenetischen Modulatoren SETD2 und EZH2 auf Tumorwachstum und Chemotherapeutikaresistenz Chemische Modulation der medizinisch relevanten HtrA Proteasen DegS und HTRA1 Cross-species evaluation of Pan-RAF inhibitor LY3009120 or SOS1::KRAS inhibitor BI-3406 in human, canine, and equine malignant melanoma Design and synthesis of peptide and small molecule protein-RNA interaction inhibitors Design und Synthese potenzieller Inhibitoren der bakteriellen RNase P und des eukaryotischen Initiationsfaktors 4A, sowie Synthese von Modulatoren des M3-Rezeptors Development and Optimisation of Novel Heterocyclic Inhibitors of Flaviviral Proteases with Antiviral Activity Development of a New Class of Necroptosis Inhibitors That Bind Allosterically to Human and Mouse MLKL Development of inhibitors against the ADPR-binding macrodomain of the non-structuralprotein 3 of SARS-CoV-2

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Inhibitor

Charakterisierung von inhibitorischen Synapsen in der Säugernetzhaut

Development of covalent DPP8/9 inhibitors

Discovery and characterization of Kunitz inhibitors as antivirals against Corona and Influenza viruses

From structural insights to small-molecule inhibitors: targeting the SARS-CoV-2 RNA element SL1

High-throughput screening for KRAS-G12D inhibitor combination strategies in murine PDAC models

Identification and characterization of novel inhibitors of bacterial AB-type toxins

Mechanisms of resistance to BTK inhibitors independent of BTK and PLCG2 mutations

Synthese und biologische Evaluierung von Inhibitoren der Carboanhydrase II

Systematic Comparison of Histone Deacetylase Inhibitors Manipulating the Expression of Human T-cell Lymphotropic Virus Type 1

Targeting ALC1 for synthetic lethality in cancer : a superior alternative to PARP inhibitors

Analyse zur nichtkanonischen Wirkung von Inhibitoren der Transkriptionskontrolle im Harnblasenkarzinom

Characterization of novel NEDDylation inhibitors in in vitro models of atherogenesis

Characterization of the effect of a GLUT1 inhibitor on macrophages and T cells for modulating the immune response to myocardial infarction

Charakterisierung des Immunphänotyps von Urothelkarzinom- Zelllinien sowie Tumor-Zelllinien von Kopf und Hals nach Behandlung mit epigenetischen Inhibitoren

Charakterisierung von GISB-284 als Inhibitor von Metallo-β-Lactamasen

Computer-based analysis of histone deacetylase 10 and its inhibitor complexes

Corrosion inhibitors for bare and PEO-coated Mg alloys

Design and Synthesis of FK506 binding protein inhibitors acting as anti-infectives and as molecular glues

Development of small molecule inhibitors of the bacterial toxin pneumolysin

Duale BRD4 und PLK1 Inhibitoren im Rhabdomyosarkom

Experimentelle Untersuchungen zur vermuteten Rolle der Dipeptidyl-Peptidase-IV Inhibitoren als Auslöser akuter Krankheitsausbrüche des bullösen Pemphigoids

Identification and characterization of human endogenous proteins and peptides as novel inhibitors for the Bordetella pertussis toxin and related AB-type protein toxins

In Silico Design of Novel Inhibitors for Cancer-Related Targets

In vitro testing of histone deacetylase inhibitors (HDACi) in combination with temozolomide radio-chemotherapy as a treatment strategy for pediatric high-grade gliomas (pedHGG)

Investigation of PINK1 cleavage and trafficking using novel PARL-targeted α-ketoamide-based inhibitors

Investigation of Rlig1: from discovery of inhibitors to functional characterization

Modulation of the cGAS/STING pathway in various tumor cell lines by a novel HSP90 inhibitor

Molecular Mechanisms of Nephroprotection of SGLT2 Inhibitor

Molecular modeling and design of selective histone deacetylase 11 (HDAC11) inhibitors

Multivalent polymer-peptide conjugates as inhibitors of SARS-CoV-2

New Strategies for Cancer Therapy – Development of Fluorescent Labeling Techniques, Novel Inhibitors and Photoswitchable Probes

Pharmacological Studies on TRPC6 Inhibitors

Preclinical evaluation of histone deacetylase inhibitors for epigenetic therapy of diffuse large B-cell lymphoma

Prospektive Untersuchung von prognostischen Markern des Nierenschadens beim kardiorenalen Syndrom: Erfassung der Auswirkung von SGLT2 Inhibitoren auf Parameter der renalen Kongestion

QSAR-guided design and synthesis of novel inhibitors targeting KRAS protein-protein interactions

Quantitative mass spectrometry-based (chemo-) proteomics for the characterization of MEP pathway inhibitors

Strukturbasiertes Design von Inhibitoren der bakteriellen Pyocyanin-Biosynthese

Strukturbasiertes Design, Synthese und Evaluation dual-kovalenter Immunoproteasom- und SARS-CoV-2 Mᵖʳᵒ-Inhibitoren

The role of RB and its complex in CDK4/6 inhibitor therapy: Mechanisms of cell cycle regulation and oncolytic virus replication

Thrombospondin-1 as inhibitor of the alternative complement pathway in antineutrophil cytoplasmic antibodyassociated vasculitis

Untersuchungen zur gezielten Behandlung FLT3-ITD-positiver AML-Zellen mit hohen SKI-Leveln mit verschiedenen Inhibitoren

Von peptidischen zu nicht-peptidischen Hemmstoffen der Proproteinconvertase Furin

Absolute Behandlungseffekte der primären Endpunkte und der Gesamtmortalität in den kardiovaskulären Endpunktstudien der neuen Antidiabetika: Meta-Analyse digitalisierter Patientendaten

Activator and inhibitor interactions and expression during trichome patterning in Arabidopsis thaliana

Angiotensin-Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker in Cerebral Arteriogenesis

Antineoplastische Wirkung von Inhibitoren der Poly(ADP-ribose)-Polymerase-1 in Kombination mit Inhibitoren der Zellzykluskinasen CDK4 und CDK6 in Ewing-Sarkomzellen

Bacterial-Derived Metabolites in the Context of Immune Checkpoint Inhibitor Cancer Therapy

Bedeutung der Homologen Rekombination für die Wirkung des dualen PI3K/mTOR-Inhibitors NVP-BEZ235 auf eine kombinierte Behandlung von Kopf-Hals-Tumorzellen mit Cisplatin und Bestrahlung

Bekämpfung antibakterieller Resistenz: Entwicklung neuartiger Enzymassays zur Charakterisierung von Inhibitoren der Lipid A-Biosynthese

Characterization of PARP inhibitor resistance in patient-derived ovarian cancer cell lines

Characterization of the role of the atypical NF-κB inhibitor protein, "IκBNS" in regulatory T cells and its interaction with NF-κB1

Charakterisierung der Rolle von Smad7 bei der Entstehung und Entwicklung des Pankreaskarzinoms

Charakterisierung genetischer Aberrationen in T-Zell Neoplasien und Einfluss der epigenetischen Modulatoren SETD2 und EZH2 auf Tumorwachstum und Chemotherapeutikaresistenz

Chemische Modulation der medizinisch relevanten HtrA Proteasen DegS und HTRA1

Cross-species evaluation of Pan-RAF inhibitor LY3009120 or SOS1::KRAS inhibitor BI-3406 in human, canine, and equine malignant melanoma

Design and synthesis of peptide and small molecule protein-RNA interaction inhibitors

Design und Synthese potenzieller Inhibitoren der bakteriellen RNase P und des eukaryotischen Initiationsfaktors 4A, sowie Synthese von Modulatoren des M3-Rezeptors

Development and Optimisation of Novel Heterocyclic Inhibitors of Flaviviral Proteases with Antiviral Activity

Development of a New Class of Necroptosis Inhibitors That Bind Allosterically to Human and Mouse MLKL

Development of inhibitors against the ADPR-binding macrodomain of the non-structuralprotein 3 of SARS-CoV-2