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Person

Tilman Brummer (1970-)

Biologe

Name	Tilman Brummer
Zeit	1970- (Lebensdaten)
Ort	Freiburg im Breisgau (Wirkungsort) Deutschland
Geschlecht	männlich
Akademischer Grad bzw. Titel	Dr.
Beruf	Biologe (charakteristischer Beruf) Hochschullehrer
Beziehung	Albert-Ludwigs-Universität Freiburg. Institut für Molekulare Medizin und Zellforschung (2008-)
Themengebiet	Personen zu allgemeiner Biologie, Mikrobiologie
Quelle	Homepage: https://www.bioss.uni-freiburg.de/prof-dr-tilman-brummer (Stand: 19.10.2018) Landesbibliographie Baden-Württemberg
Datensatztyp	Person
GND-Nummer	1100289917
Datensatz-ID	1100289917
Beteiligt an alle anzeigen The mTOR pathway controls phosphorylation of BRAF at T401 Comprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors DYRK1A signalling synchronizes the mitochondrial import pathways for metabolic rewiring Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease Comprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer DYRK1A signalling synchronizes the mitochondrial import pathways for metabolic rewiring Enzyme is the name : : adapter is the game Identification of low molecular weight peptides targeting EpCAM and CD44v6 MOST wanted: navigating the MAPK-OIS-SASP-tumor microenvironment axis in primary pediatric low-grade glioma and preclinical models Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease The mTOR pathway controls phosphorylation of BRAF at T401 The role of the MDM2/p53 axis in anti-tumor immune responses Analysis of RAS and drug induced homo- and heterodimerization of RAF and KSR1 proteins in living cells using split Nanoluc luciferase Analysis of RAS and drug induced homo- and heterodimerization of RAF and KSR1 proteins in living cells using split Nanoluc luciferase BRAF Δβ3-αC in-frame deletion mutants differ in their dimerization propensity, HSP90 dependence, and druggability = BRAF [delta][beta]3-[alpha]C in-frame deletion mutants differ in their dimerization propensity, HSP90 dependence, and druggability Characterization of the immunosuppressive tumour microenvironment in a mouse model of clear cell renal cell carcinoma Impact of signaling pathways and the extracellular matrix in cancer development MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas Mast cell deficiency prevents BCR::ABL1 induced splenomegaly and cytokine elevation in a CML mouse model Mast cell deficiency prevents BCR::ABL1 induced splenomegaly and cytokine elevation in a CML mouse model The secretome of colorectal cancer influences metastasis and the tumor microenvironment modulates its dysregulation Degradome-focused RNA interference screens to identify proteases important for breast cancer cell growth Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo Onco-immunomodulatory properties of pharmacological interference with RAS-RAF-MEK-ERK pathway hyperactivation Potassium channel Kir6.1 is associated with the progression of hereditary multiple osteochondromas RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse Dynamic transcriptome analysis reveals signatures of paradoxical effect of vemurafenib on human dermal fibroblasts Dynamic transcriptome analysis reveals signatures of paradoxical effect of vemurafenib on human dermal fibroblasts Functional coupling of presequence processing and degradation in human mitochondria Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery Sensitivity and resistance of oncogenic RAS-driven tumors to dual MEK and ERK inhibition Sensitivity and resistance of oncogenic RAS-driven tumors to dual MEK and ERK inhibition Transitioning the molecular tumor board from proof of concept to clinical routine: a german single-center analysis BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling Immune modulatory effects of oncogenic KRAS in cancer Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines CDK9‐mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery Personalized clinical decision making through implementation of a molecular tumor board: a German single-center experience Personalized clinical decision making through implementation of a molecular tumor board: a German single-center experience Targeting oncogenic Ras by the Clostridium perfringens toxin TpeL RAF-Inhibitoren Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-integrin-[beta]1expression Specific role of RhoC in tumor invasion and metastasis The atypical kinase RIOK1 promotes tumor growth and invasive behavior Axitinib and sorafenib are potent in tyrosine kinase inhibitor resistant chronic myeloid leukemia cells The role of STAT5 in FLT3-ITD-mediated leukemogenesis Exometabolom analysis of breast cancer cell lines: metabolic signature EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells A novel MCF-10A line allowing conditional oncogene expression in 3D culture ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer

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Katalog der Deutschen Nationalbibliothek

Tilman Brummer (1970-)

The mTOR pathway controls phosphorylation of BRAF at T401

Comprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors

DYRK1A signalling synchronizes the mitochondrial import pathways for metabolic rewiring

Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines

ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease

Comprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors

Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer

DYRK1A signalling synchronizes the mitochondrial import pathways for metabolic rewiring

Enzyme is the name : : adapter is the game

Identification of low molecular weight peptides targeting EpCAM and CD44v6

MOST wanted: navigating the MAPK-OIS-SASP-tumor microenvironment axis in primary pediatric low-grade glioma and preclinical models

Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines

ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease

The mTOR pathway controls phosphorylation of BRAF at T401

The role of the MDM2/p53 axis in anti-tumor immune responses

Analysis of RAS and drug induced homo- and heterodimerization of RAF and KSR1 proteins in living cells using split Nanoluc luciferase

Analysis of RAS and drug induced homo- and heterodimerization of RAF and KSR1 proteins in living cells using split Nanoluc luciferase

BRAF Δβ3-αC in-frame deletion mutants differ in their dimerization propensity, HSP90 dependence, and druggability = BRAF [delta][beta]3-[alpha]C in-frame deletion mutants differ in their dimerization propensity, HSP90 dependence, and druggability

Characterization of the immunosuppressive tumour microenvironment in a mouse model of clear cell renal cell carcinoma

Impact of signaling pathways and the extracellular matrix in cancer development

MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas

Mast cell deficiency prevents BCR::ABL1 induced splenomegaly and cytokine elevation in a CML mouse model

Mast cell deficiency prevents BCR::ABL1 induced splenomegaly and cytokine elevation in a CML mouse model

The secretome of colorectal cancer influences metastasis and the tumor microenvironment modulates its dysregulation

Degradome-focused RNA interference screens to identify proteases important for breast cancer cell growth

Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo

Onco-immunomodulatory properties of pharmacological interference with RAS-RAF-MEK-ERK pathway hyperactivation

Potassium channel Kir6.1 is associated with the progression of hereditary multiple osteochondromas

RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells

Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse

Dynamic transcriptome analysis reveals signatures of paradoxical effect of vemurafenib on human dermal fibroblasts

Dynamic transcriptome analysis reveals signatures of paradoxical effect of vemurafenib on human dermal fibroblasts

Functional coupling of presequence processing and degradation in human mitochondria

Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery

Sensitivity and resistance of oncogenic RAS-driven tumors to dual MEK and ERK inhibition

Sensitivity and resistance of oncogenic RAS-driven tumors to dual MEK and ERK inhibition

Transitioning the molecular tumor board from proof of concept to clinical routine: a german single-center analysis

BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation

Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling

Immune modulatory effects of oncogenic KRAS in cancer

Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation

B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model

BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines

CDK9‐mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery

Personalized clinical decision making through implementation of a molecular tumor board: a German single-center experience

Personalized clinical decision making through implementation of a molecular tumor board: a German single-center experience

Targeting oncogenic Ras by the Clostridium perfringens toxin TpeL

RAF-Inhibitoren

Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition

Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-integrin-[beta]1expression

Specific role of RhoC in tumor invasion and metastasis

The atypical kinase RIOK1 promotes tumor growth and invasive behavior

Axitinib and sorafenib are potent in tyrosine kinase inhibitor resistant chronic myeloid leukemia cells

The role of STAT5 in FLT3-ITD-mediated leukemogenesis

Exometabolom analysis of breast cancer cell lines: metabolic signature

EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells

Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells

Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells

A novel MCF-10A line allowing conditional oncogene expression in 3D culture

ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer