Detailansicht

Wissensnetz

Person

Roland Schüle (1957-)

Biochemiker

Name	Roland Schüle
Zeit	1957- (Lebensdaten)
Ort	Neuenstadt am Kocher (Geburtsort) Freiburg im Breisgau (Wirkungsort) Deutschland
Akademischer Grad bzw. Titel	Prof. Dr. rer. nat.
Beruf	Biochemiker (charakteristischer Beruf)
Variante	Roland Schuele
Beziehung	Universitätsklinikum Freiburg. Hormone Dependent Cancer Universitätsklinikum Freiburg. Klinik für Urologie (2010-) Universitätsklinikum Freiburg. Zentrale Klinische Forschung Universitätsklinikum Freiburg. Studienzentrum (1999-) DKTK German Cancer Consortium Chemie (Studienfach) Biochemie (Studienfach)
Datensatztyp	Person
GND-Nummer	1110921403
Datensatz-ID	1110921403
Beteiligt an alle anzeigen Soft drug inhibitors for the epigenetic targets lysine‐specific demethylase 1 and histone deacetylases LSD1 inhibition circumvents glucocorticoid-induced muscle wasting of male mice Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity LSD1 inhibition circumvents glucocorticoid-induced muscle wasting of male mice Lysine methyltransferase 9 (KMT9) is an actionable target in muscle-invasive bladder cancer Soft drug inhibitors for the epigenetic targets lysine‐specific demethylase 1 and histone deacetylases Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity Four-and-a-half LIM-domain protein 2 (FHL2) induces neuropeptide Y (NPY) inmacrophages in visceral adipose tissue and promotes diet-induced obesity Nutrient regulation of the islet epigenome controls adaptive insulin secretion Overexpression of KMT9α is associated with aggressive basal-like muscle-invasive bladder cancer Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B cell lymphomas KMT9 controls stemness and growth of colorectal cancer Structure-based design, docking and binding free energy calculations of A366 derivatives as spindlin1 inhibitors Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death Nitroreductase‐Mediated Release of Inhibitors of Lysine‐Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells † Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death Epigenetics meets GPCR: inhibition of histone H3 methyltransferase (G9a) and histamine H3 receptor for Prader–Willi Syndrome Next‐generation sequencing reveals a novel role of lysine‐specific demethylase 1 in adhesion of rhabdomyosarcoma cells Nitroreductase‐mediated release of inhibitors of lysine‐specific demethylase 1 (lsd1) from prodrugs in transfected acute myeloid leukaemia cells KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML Characterization of novel histone methyltransferases and their roles in cancer Next-generation sequencing reveals a novel role of lysine-specific demethylase 1 in adhesion of rhabdomyosarcoma cells Structural insights into a novel histone methyltransferase - KMT9 Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells Identification of fragments binding to CHD1 double chromodomain, an epigenetic reader of KDM1A K114me2 and H3 K4me3 Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4 LSD1 controls timely MyoD expression via MyoD core enhancer transcription Prenatal thalamic waves regulate cortical area size prior to sensory processing The histone code reader Spin1 controls skeletal muscle development 4‐Biphenylalanine‐ and 3‐Phenyltyrosine‐Derived Hydroxamic Acids as Inhibitors of the JumonjiC‐Domain‐Containing Histone Demethylase KDM4A Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance The histone code reader SPIN1 controls RET signaling in liposarcoma Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate Lysine-Specific Demethylase 1 Has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells Transcriptional repressor NIR interacts with the p53-inhibiting ubiquitin ligase MDM2 4‐Acyl Pyrroles: Mimicking Acetylated Lysines in Histone Code Reading † 4‐Acyl Pyrroles: Mimicking Acetylated Lysines in Histone Code Reading † A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2 Characterisation of H3K64 trimethylation as novel heterochromatic mark in the context of DNA methylation and H3K9 trimethylation = Charakterisierung der heterochromatischen Histonmodifikation H3K64 Trimethylierung im Kontext von DNA Methylierung und H3K9 Trimethylierung Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor‐α target gene activation by regulating lysine demethylase 1 specificity NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus Analyse der Expressionsregulation des Tryptophanoxygenase-Gens in Rattenleber

Hinweis

Die Betaversion beinhaltet noch nicht alle Funktionen und Informationen des Katalogs des DNB-Portals. Falls Sie Informationen vermissen oder ein Medium bestellen wollen, besuchen Sie bitte die entsprechende Seite im Katalog des DNB-Portals über folgenden Link:

Katalog der Deutschen Nationalbibliothek

Roland Schüle (1957-)

Soft drug inhibitors for the epigenetic targets lysine‐specific demethylase 1 and histone deacetylases

LSD1 inhibition circumvents glucocorticoid-induced muscle wasting of male mice

Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity

LSD1 inhibition circumvents glucocorticoid-induced muscle wasting of male mice

Lysine methyltransferase 9 (KMT9) is an actionable target in muscle-invasive bladder cancer

Soft drug inhibitors for the epigenetic targets lysine‐specific demethylase 1 and histone deacetylases

Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity

Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity

Four-and-a-half LIM-domain protein 2 (FHL2) induces neuropeptide Y (NPY) inmacrophages in visceral adipose tissue and promotes diet-induced obesity

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

Overexpression of KMT9α is associated with aggressive basal-like muscle-invasive bladder cancer

Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death

Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration

Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B cell lymphomas

KMT9 controls stemness and growth of colorectal cancer

Structure-based design, docking and binding free energy calculations of A366 derivatives as spindlin1 inhibitors

Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death

Nitroreductase‐Mediated Release of Inhibitors of Lysine‐Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells †

Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death

Epigenetics meets GPCR: inhibition of histone H3 methyltransferase (G9a) and histamine H3 receptor for Prader–Willi Syndrome

Next‐generation sequencing reveals a novel role of lysine‐specific demethylase 1 in adhesion of rhabdomyosarcoma cells

Nitroreductase‐mediated release of inhibitors of lysine‐specific demethylase 1 (lsd1) from prodrugs in transfected acute myeloid leukaemia cells

KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells

LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML

Characterization of novel histone methyltransferases and their roles in cancer

Next-generation sequencing reveals a novel role of lysine-specific demethylase 1 in adhesion of rhabdomyosarcoma cells

Structural insights into a novel histone methyltransferase - KMT9

Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells

Identification of fragments binding to CHD1 double chromodomain, an epigenetic reader of KDM1A K114me2 and H3 K4me3

Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells

Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells

Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells

Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4

LSD1 controls timely MyoD expression via MyoD core enhancer transcription

Prenatal thalamic waves regulate cortical area size prior to sensory processing

The histone code reader Spin1 controls skeletal muscle development

4‐Biphenylalanine‐ and 3‐Phenyltyrosine‐Derived Hydroxamic Acids as Inhibitors of the JumonjiC‐Domain‐Containing Histone Demethylase KDM4A

Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform

Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance

The histone code reader SPIN1 controls RET signaling in liposarcoma

Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate

Lysine-Specific Demethylase 1 Has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity

PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells

Transcriptional repressor NIR interacts with the p53-inhibiting ubiquitin ligase MDM2

4‐Acyl Pyrroles: Mimicking Acetylated Lysines in Histone Code Reading †

4‐Acyl Pyrroles: Mimicking Acetylated Lysines in Histone Code Reading †

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2

Characterisation of H3K64 trimethylation as novel heterochromatic mark in the context of DNA methylation and H3K9 trimethylation = Charakterisierung der heterochromatischen Histonmodifikation H3K64 Trimethylierung im Kontext von DNA Methylierung und H3K9 Trimethylierung

Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells

Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP

PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor‐α target gene activation by regulating lysine demethylase 1 specificity

NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle

The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus

Analyse der Expressionsregulation des Tryptophanoxygenase-Gens in Rattenleber