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Josef Pfeilschifter

Arzt

Name	Josef Pfeilschifter
Zeit	1982- (Wirkungsdaten)
Ort	Deutschland
Akademischer Grad bzw. Titel	Prof. Dr.
Beruf	Arzt (charakteristischer Beruf) Dozent
Variante	Josef M. Pfeilschifter Josef Martin Pfeilschifter
Beziehung	Goethe-Universität Frankfurt am Main. Medizinische Fakultät
Weitere Angaben	Promotion 1982 Technische Univ. München, Habilitation 1990 Univ. Basel; Forschungsschwerpunkte: Pharmakologie, Toxikologie, Nephrologie, Krebsforschung; seit 2002 Dekan der Medizinischen Fakultät, Goethe-Universität Frankfurt am Main
Datensatztyp	Person
GND-Nummer	1205515984
Datensatz-ID	1205515984
Beteiligt an alle anzeigen Funktionelle Analysen zur Interaktion des ORF10 Proteins von Borrelia recurrentis mit dem humanen Komplementsystem Translational regulation of resolution of inflammation in macrophages Disruption of p54nrb's gene regulatory function by caspase-2 exhibits a multifaceted role in tumor cell death susceptibility Impact of Moderna mRNA-1273 booster vaccine on fully vaccinated high-risk chronic dialysis patients after loss of humoral response Sphingosine 1-phosphate receptor 5 (S1P5) knockout ameliorates adenine-induced nephropathy Sphk1 and Sphk2 differentially regulate erythropoietin synthesis in mouse renal interstitial fibroblast-like cells The atypical sphingosine 1-phosphate variant, d16:1 S1P, mediates CTGF induction via S1P2 activation in renal cell carcinoma The pathophysiology of H2S in renal glomerular diseases Application of pseudotyped virus particles to monitor Ebola virus and SARS-CoV-2 viral entry in human cell lines ATP potentiates interleukin-1β-induced MMP-9 expression in mesangial cells via recruitment of the ELAV protein HuR Biglycan, a nitric oxide-regulated gene, affects adhesion, growth, and survival of mesangial cells Enhanced CXCR4 expression of human CD8Low T lymphocytes is driven by S1P4 IL-36γ/IL-1F9, an innate T-bet target in myeloid cells Inhibition of cytokine-induced matrix metalloproteinase 9 expression by peroxisome proliferator-activated receptor alpha agonists is indirect and due to a NO-mediated reduction of mRNA stability Mechanisms of rapid induction of interleukin-22 in activated T cells and its modulation by cyclosporin a Mouse liver compensates loss of Sgpl1 by secretion of sphingolipids into blood and bile Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells Nitric oxide induces degradation of the neutral ceramidase in rat renal mesangial cells and is counterregulated by protein kinase C Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway p68 DEAD box RNA helicase expression in keratinocytes : regulation, nucleolar localization, and functional connection to proliferation and vascular endothelial growth factor gene expression Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1β-induced prostaglandin E2 formation A murine cellular model of necroinflammation displays RAGE‐dependent cytokine induction that connects to hepatoma cell injury A sphingosine 1-phosphate gradient is linked to the cerebral recruitment of T helper and regulatory T helper cells during acute ischemic stroke A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke Inflammation-induced mucosal KYNU expression identifies human ileal Crohn’s disease Multifaceted roles of TRIM proteins in colorectal carcinoma S1P d20:1, an endogenous modulator of S1P d18:1/S1P2-dependent signaling S1P lyase siRNA dampens malignancy of DLD‐1 colorectal cancer cells Sorafenib treatment and modulation of the sphingolipid pathway affect proliferation and viability of hepatocellular carcinoma In vitro The S1P–S1PR axis in neurological disorders - insights into current and future therapeutic perspectives National survey of evaluation practices and performance-guided resource allocation at German medical schools Bildung und Freiheit - von der (Un-)Freiheit der medizinischen Fakultät Bundesweite Erhebung zur Lehrevaluation und Leistungsorientierten Mittelvergabe in der Lehre an den medizinischen Fakultäten in Deutschland Identification of trim25 as a negative regulator of caspase-2 expression reveals a novel target for sensitizing colon carcinoma cells to intrinsic apoptosis National survey of evaluation practices and performance-guided resource allocation at German medical schools Tissue cytokine IL-33 modulates the cytotoxic CD8 t lymphocyte activity during nutrient deprivation by regulation of lineage-specific differentiation programs Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis A prominent role of interleukin-18 in acetaminophen-induced liver injury advocates its blockage for therapy of hepatic necroinflammation Beta adrenoceptor blockade ameliorates impaired glucose tolerance and alterations of the cerebral ceramide metabolism in an experimental model of ischemic stroke Downregulation of the S1P transporter spinster homology protein 2 (Spns2) exerts an anti-fibrotic and anti-inflammatory effect in human renal proximal tubular epithelial cells Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells Low serum levels of (dihydro-)ceramides reflect liver graft dysfunction in a real-world cohort of patients post liver transplantation Preanalytical biases in the measurement of human blood sphingolipids Serum sphingolipid levels associate with upcoming virologic events and HBV genotype D in a cohort of patients with HBeAg-negative HBV infection Nitric oxide mediates prolyl hydroxylase 3 expression in mesangial cells and in glomerulonephritis Biglycan- and sphingosine kinase-1 signaling crosstalk regulates the synthesis of macrophage chemoattractants Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage Defective IL-23/IL-17 Axis Protects p47phox−/− Mice from Colon Cancer Hypothermia promotes interleukin-22 expression and fine-tunes its biological activity Nuclear translocation of SGPP-1 and decrease of SGPL-1 activity contribute to sphingolipid rheostat regulation of inflammatory dendritic cells Sphingosine-1-Phosphate receptor 5 modulates early-stage processes during fibrogenesis in a mouse model of systemic sclerosis : a pilot study Type I interferon supports inducible nitric oxide synthase in murine hepatoma cells and hepatocytes and during experimental acetaminophen-induced liver damage Vitamin D supplementation enhances C18(dihydro)ceramide levels in type 2 diabetes patients Anti-inflammatory effects of rosiglitazone in obesity-impaired wound healing depend on adipocyte differentiation Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis Erratum: Tristetraprolin regulation of interleukin-22 production Persistence of HCV in acutely-infected patients depletes C24-ceramide and upregulates sphingosine and sphinganine serum levels Quantitative persulfide site identification (qPerS-SID) reveals protein targets of H2S releasing donors in mammalian cells Tristetraprolin regulation of interleukin-22 production

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Katalog der Deutschen Nationalbibliothek

Josef Pfeilschifter

Funktionelle Analysen zur Interaktion des ORF10 Proteins von Borrelia recurrentis mit dem humanen Komplementsystem

Translational regulation of resolution of inflammation in macrophages

Disruption of p54nrb's gene regulatory function by caspase-2 exhibits a multifaceted role in tumor cell death susceptibility

Impact of Moderna mRNA-1273 booster vaccine on fully vaccinated high-risk chronic dialysis patients after loss of humoral response

Sphingosine 1-phosphate receptor 5 (S1P5) knockout ameliorates adenine-induced nephropathy

Sphk1 and Sphk2 differentially regulate erythropoietin synthesis in mouse renal interstitial fibroblast-like cells

The atypical sphingosine 1-phosphate variant, d16:1 S1P, mediates CTGF induction via S1P2 activation in renal cell carcinoma

The pathophysiology of H2S in renal glomerular diseases

Application of pseudotyped virus particles to monitor Ebola virus and SARS-CoV-2 viral entry in human cell lines

ATP potentiates interleukin-1β-induced MMP-9 expression in mesangial cells via recruitment of the ELAV protein HuR

Biglycan, a nitric oxide-regulated gene, affects adhesion, growth, and survival of mesangial cells

Enhanced CXCR4 expression of human CD8Low T lymphocytes is driven by S1P4

IL-36γ/IL-1F9, an innate T-bet target in myeloid cells

Inhibition of cytokine-induced matrix metalloproteinase 9 expression by peroxisome proliferator-activated receptor alpha agonists is indirect and due to a NO-mediated reduction of mRNA stability

Mechanisms of rapid induction of interleukin-22 in activated T cells and its modulation by cyclosporin a

Mouse liver compensates loss of Sgpl1 by secretion of sphingolipids into blood and bile

Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells

Nitric oxide induces degradation of the neutral ceramidase in rat renal mesangial cells and is counterregulated by protein kinase C

Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway

p68 DEAD box RNA helicase expression in keratinocytes : regulation, nucleolar localization, and functional connection to proliferation and vascular endothelial growth factor gene expression

Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1β-induced prostaglandin E2 formation

A murine cellular model of necroinflammation displays RAGE‐dependent cytokine induction that connects to hepatoma cell injury

A sphingosine 1-phosphate gradient is linked to the cerebral recruitment of T helper and regulatory T helper cells during acute ischemic stroke

A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke

Inflammation-induced mucosal KYNU expression identifies human ileal Crohn’s disease

Multifaceted roles of TRIM proteins in colorectal carcinoma

S1P d20:1, an endogenous modulator of S1P d18:1/S1P2-dependent signaling

S1P lyase siRNA dampens malignancy of DLD‐1 colorectal cancer cells

Sorafenib treatment and modulation of the sphingolipid pathway affect proliferation and viability of hepatocellular carcinoma In vitro

The S1P–S1PR axis in neurological disorders - insights into current and future therapeutic perspectives

National survey of evaluation practices and performance-guided resource allocation at German medical schools

Bildung und Freiheit - von der (Un-)Freiheit der medizinischen Fakultät

Bundesweite Erhebung zur Lehrevaluation und Leistungsorientierten Mittelvergabe in der Lehre an den medizinischen Fakultäten in Deutschland

Identification of trim25 as a negative regulator of caspase-2 expression reveals a novel target for sensitizing colon carcinoma cells to intrinsic apoptosis

National survey of evaluation practices and performance-guided resource allocation at German medical schools

Tissue cytokine IL-33 modulates the cytotoxic CD8 t lymphocyte activity during nutrient deprivation by regulation of lineage-specific differentiation programs

Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis

A prominent role of interleukin-18 in acetaminophen-induced liver injury advocates its blockage for therapy of hepatic necroinflammation

Beta adrenoceptor blockade ameliorates impaired glucose tolerance and alterations of the cerebral ceramide metabolism in an experimental model of ischemic stroke

Downregulation of the S1P transporter spinster homology protein 2 (Spns2) exerts an anti-fibrotic and anti-inflammatory effect in human renal proximal tubular epithelial cells

Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells

Low serum levels of (dihydro-)ceramides reflect liver graft dysfunction in a real-world cohort of patients post liver transplantation

Preanalytical biases in the measurement of human blood sphingolipids

Serum sphingolipid levels associate with upcoming virologic events and HBV genotype D in a cohort of patients with HBeAg-negative HBV infection

Nitric oxide mediates prolyl hydroxylase 3 expression in mesangial cells and in glomerulonephritis

Biglycan- and sphingosine kinase-1 signaling crosstalk regulates the synthesis of macrophage chemoattractants

Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage

Defective IL-23/IL-17 Axis Protects p47phox−/− Mice from Colon Cancer

Hypothermia promotes interleukin-22 expression and fine-tunes its biological activity

Nuclear translocation of SGPP-1 and decrease of SGPL-1 activity contribute to sphingolipid rheostat regulation of inflammatory dendritic cells

Sphingosine-1-Phosphate receptor 5 modulates early-stage processes during fibrogenesis in a mouse model of systemic sclerosis : a pilot study

Type I interferon supports inducible nitric oxide synthase in murine hepatoma cells and hepatocytes and during experimental acetaminophen-induced liver damage

Vitamin D supplementation enhances C18(dihydro)ceramide levels in type 2 diabetes patients

Anti-inflammatory effects of rosiglitazone in obesity-impaired wound healing depend on adipocyte differentiation

Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L

Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis

Erratum: Tristetraprolin regulation of interleukin-22 production

Persistence of HCV in acutely-infected patients depletes C24-ceramide and upregulates sphingosine and sphinganine serum levels

Quantitative persulfide site identification (qPerS-SID) reveals protein targets of H2S releasing donors in mammalian cells

Tristetraprolin regulation of interleukin-22 production