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Dieter Edbauer (1976-)

Name	Dieter Edbauer
Zeit	1976- (Lebensdaten)
Ort	Sonstiges Ausland / Unbekanntes Land
Variante	Dieter Johannes Edbauer
Weitere Angaben	Diss. Medizinische Fakultät
Datensatztyp	Person
GND-Nummer	124501028
Datensatz-ID	124501028
Beteiligt an alle anzeigen Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo Gel‐like inclusions of C‐terminal fragments of TDP‐43 sequester stalled proteasomes in neurons Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants Clinico-genetic findings in 509 frontotemporal dementia patients Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS Cell‐to‐cell transmission of C9orf72 poly‐(Gly‐Ala) triggers key features of ALS/FTD Loss of TMEM 106B potentiates lysosomal and FTLD ‐like pathology in progranulin‐deficient mice Synaptic dysfunction induced by glycine‐alanine dipeptides in C9orf72‐ ALS/FTD is rescued by SV 2 replenishment Active poly‐GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice Poly-glycine–alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3 Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers RNA versus protein toxicity in C9orf72 ALS/FTLD A novel CHCHD10 mutation implicates a Mia40‐dependent mitochondrial import deficit in ALS Targeting RNA G‐quadruplexes as new treatment strategy for C9orf72 ALS/FTD Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration Poly‐ GP in cerebrospinal fluid links C9orf72 ‐associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD Antibodies inhibit transmission and aggregation of C9orf72 poly‐ GA dipeptide repeat proteins Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS TDP‐43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons Reduced hn RNPA 3 increases C9orf72 repeat RNA levels and dipeptide‐repeat protein deposition Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing Proteolytic processing of neuregulin 1 type III by three intramembrane-cleaving proteases Good guy or bad guy: the opposing roles of microRNA 125b in cancer Micro RNA ‐125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease The ER under rapid fire The FTLD risk factor TMEM 106B and MAP 6 control dendritic trafficking of lysosomes Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations Promoter DNA methylation regulates progranulin expression and is altered in FTLD hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations Promoter DNA methylation regulates progranulin expression and is altered in FTLD Loss of fused in sarcoma (FUS) promotes pathological Tau splicing Reconstitution of gamma-secretase activity DNA-Vakzinierung mit Idiotyp-Zytokin-Fusionskonstrukten gegen Lymphome im Mausmodell DNA-Vakzinierung mit Idiotyp-Zytokin-Fusionskonstrukten gegen Lymphome im Mausmodell

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Dieter Edbauer (1976-)

Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits

Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target

Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo

Gel‐like inclusions of C‐terminal fragments of TDP‐43 sequester stalled proteasomes in neurons

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation

Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants

Clinico-genetic findings in 509 frontotemporal dementia patients

Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS

Cell‐to‐cell transmission of C9orf72 poly‐(Gly‐Ala) triggers key features of ALS/FTD

Loss of TMEM 106B potentiates lysosomal and FTLD ‐like pathology in progranulin‐deficient mice

Synaptic dysfunction induced by glycine‐alanine dipeptides in C9orf72‐ ALS/FTD is rescued by SV 2 replenishment

Active poly‐GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice

Poly-glycine–alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD

FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers

RNA versus protein toxicity in C9orf72 ALS/FTLD

A novel CHCHD10 mutation implicates a Mia40‐dependent mitochondrial import deficit in ALS

Targeting RNA G‐quadruplexes as new treatment strategy for C9orf72 ALS/FTD

Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss

Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration

Poly‐ GP in cerebrospinal fluid links C9orf72 ‐associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD

Antibodies inhibit transmission and aggregation of C9orf72 poly‐ GA dipeptide repeat proteins

Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD

Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS

TDP‐43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons

Reduced hn RNPA 3 increases C9orf72 repeat RNA levels and dipeptide‐repeat protein deposition

Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers

Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing

Proteolytic processing of neuregulin 1 type III by three intramembrane-cleaving proteases

Good guy or bad guy: the opposing roles of microRNA 125b in cancer

Micro RNA ‐125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease

The ER under rapid fire

The FTLD risk factor TMEM 106B and MAP 6 control dendritic trafficking of lysosomes

Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations

Promoter DNA methylation regulates progranulin expression and is altered in FTLD

hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations

Promoter DNA methylation regulates progranulin expression and is altered in FTLD

Loss of fused in sarcoma (FUS) promotes pathological Tau splicing

Reconstitution of gamma-secretase activity

DNA-Vakzinierung mit Idiotyp-Zytokin-Fusionskonstrukten gegen Lymphome im Mausmodell

DNA-Vakzinierung mit Idiotyp-Zytokin-Fusionskonstrukten gegen Lymphome im Mausmodell