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Proteasom

Proteasen

Subject heading	Proteasom
Definition	Multikatalytische Proteasekomplex
Synonym	Prosom Proteosom (Römpp Online) MCP Multicatalytic proteinase Multicatalytic endopeptidase complex (EC) EC 3.4.99.46 Ingensin Macropain
Broader term	Proteasen
Topic	Biochemie, Biophysik, Zytologie
Source	Lex. Biochem. Molekularbiol., EC
Record type	Nomenklatur (Biologie / Chemie)
GND-Identifier	4315827-4
Record ID	043158277
Topic of show all Decoding proteasomopathies: Characterization of proteasome-associated gene variants at the molecular level Characterization of the OTU-domain deubiquitinating enzymes Otu2, OTUD6A and OTUD6B Elucidating the DDI2-TCF11/NRF1 axis of proteasome gene activation and its impact on various stress signaling pathways Functional role of the immunoproteasome in (glomerular) endothelial cells Mass spectrometric analysis of small-molecule-induced ubiquitination and deubiquitination Role of p97 cofactors in protein degradation Characterization of proteasome shuttling factors and their impact on misfolded proteins in age-related neurodegenerative diseases Charakterisierung des Proteasom-Shuttling-Proteins HR23B und seiner Interaktionspartner in der Proteinqualitätskontrolle Dual-Color Single-Particle Tracking Elucidating a disease-associated mutation in HUWE1 and the mechanism of small-molecule inhibitors associated with this ligase Elucidation of Molecular Mechanisms of the Pathogenesis of Rare Proteasome associated Mendelian Disorders Exploiting the ubiquitin system to identify novel vulnerabilities in B-cell malignancies and lung adenocarcinoma Investigation into the specificities of deubiquitinases and ubiquitin-like proteases Klonierung und Expression von Mutanten des 20S-Proteasoms aus Thermoplasma acidophilum zur Untersuchung der Substrattranslokation Profiling cellular E3 ubiquitin ligase networks Regulation of the Mevalonate Pathway by the Deubiquitinase USP28 in Squamous Cancer Regulation of the ubiquitin ligase Ubr1 by the intrinsically disordered protein Roq1 Regulation of the ubiquitin ligase Ubr1 during protein quality control The membrane trafficking protein myoferlin is a novel interactor of p97 The role of the proteasome in brown adipocyte development Understanding ubiquitylation and FATylation by UBA6 Der Einfluss der Proteasomhemmung durch Bortezomib auf die Aktivierbarkeit humaner Thrombozyten Die UBX-Domäne von UBXD1 organisiert die Ubiquitinbindung am C-Terminus der AAA-ATPase VCP/p97 zum proteasomalen Abbau Dissecting the role of UBQLN2 in amyotrophic lateral sclerosis and frontotemporal dementia using multi-omics profiling Exploring the Atypical Mechanisms of Protein Ubiquitination by Ariadne E3 Ligases FAT10 and NUB1L cooperate to activate the 26S proteasome Identification and functional characterization of the E2-conjugating enzyme UBE2QL1 in endolysosomal damage response Identification of novel substrates of the Insoluble Protein Deposit (IPOD) in the yeast S. cerevisiae Impact of proteostasis and the ubiquitin proteasome system on myeloid cell function in the CNS Interactions driving Chaperone-assisted Assembly of Proteasome Core particles Interplay between α-synuclein expression and 26S proteasome chaperone Rpn14 and Rpn11 deubiquitinase in the budding yeast Saccharomyces cerevisiae Investigations into the interplay between the ubiquitin-like modifier FAT10 and the E3 ligases HUWE1 or CHIP Mass spectrometry based analyses of posttranslational protein modification in bacterial and viral (co)-infection SPATA2 regulates inflammation and cell death independently of CYLD Towards a cell-biological understanding of the formation and dissociation of neurotoxic protein aggregates Understanding the dual specificity of UBA6 USP22 controls tumorigenicity by regulating interferon responses and the stability of the tumor suppressor PML Assembly pathway of the fungal COP9 signalosome DPP9 substrates in DNA damage repair Function of deubiquitylating enzymes in the selective degradation of plasma membrane proteins in Arabidopsis thaliana Function of STAMBPL1 in Helicobacter pylori-associated cell death Functional characterisation of de novo mutations in the PSMC5 gene carried by patients with the syndromic form of intellectual disability Gezielter Proteinabbau in Pflanzen mittels chimärer E3-Ubiquitin-Ligasen Metabolic Regulation of the Ubiquitin-Proteasome System NEDD8 orchestrates active ubiquitylation assembly of cullin-RING E3 ligase Primäre Osteoarthritis der Hand – Analyse anaboler und kataboler Knochenpathologien peripherer Gelenke mittels hochauflösendem CT Verfahren Structural and functional characterization of GID/CTLH E3 ubiquitin ligases Targeting the immunoproteasome and VCP/p97 in autoimmune disorders and viral infection The Effect of Immunoproteasome Inhibition on T Helper Cells in Acute Inflammation Die Proteinausstattung eines einzelnen pflanzlichen Mitochondriums Characterization of the catalytic properties of the ubiquitin ligase E6AP Diabetes Mellitus und der Einfluss auf die Protein-Qualitäts-Kontrolle sowie auf den Abbau des sarkomerischen Proteins Titin in der Skelettmuskulatur Die Bedeutung des Immunoproteasoms und Inflammasoms bei Asthma bronchiale im Kindesalter : Studien zum „Bauernhofeffekt“ im weltweiten Vergleich Novel insights into FAT10 biology : Parkin as the first FAT10-E3 ligase and the regulation of FAT10 activity by phosphorylation Untersuchungen zum Einfluss von Nitrofettsäuren auf das Ubiquitin-Proteasom-System in Tumorzellen Einfluss eines dysfunktionalen UCH-L1-Enzyms auf die podozytäre Proteostase in der Membranösen Nephropathie Protein quality control systems in muscle : From disease to mechanism Strukturbasiertes Design, Synthese und pharmakologische Evaluation von Proteasom- und FLT3-Inhibitoren in Leukämiemodellen Untersuchungen zur Synthese von Macyranon A : Pd-katalysierte allylische Alkylierung von o-Hydroxyphenylketonen Veränderungen des Ubiquitin-Proteasom-Systems im humanen Myokard bei ischämischer und dilatativer Kardiomyopathie

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Katalog der Deutschen Nationalbibliothek

Proteasom

Decoding proteasomopathies: Characterization of proteasome-associated gene variants at the molecular level

Characterization of the OTU-domain deubiquitinating enzymes Otu2, OTUD6A and OTUD6B

Elucidating the DDI2-TCF11/NRF1 axis of proteasome gene activation and its impact on various stress signaling pathways

Functional role of the immunoproteasome in (glomerular) endothelial cells

Mass spectrometric analysis of small-molecule-induced ubiquitination and deubiquitination

Role of p97 cofactors in protein degradation

Characterization of proteasome shuttling factors and their impact on misfolded proteins in age-related neurodegenerative diseases

Charakterisierung des Proteasom-Shuttling-Proteins HR23B und seiner Interaktionspartner in der Proteinqualitätskontrolle

Dual-Color Single-Particle Tracking

Elucidating a disease-associated mutation in HUWE1 and the mechanism of small-molecule inhibitors associated with this ligase

Elucidation of Molecular Mechanisms of the Pathogenesis of Rare Proteasome associated Mendelian Disorders

Exploiting the ubiquitin system to identify novel vulnerabilities in B-cell malignancies and lung adenocarcinoma

Investigation into the specificities of deubiquitinases and ubiquitin-like proteases

Klonierung und Expression von Mutanten des 20S-Proteasoms aus Thermoplasma acidophilum zur Untersuchung der Substrattranslokation

Profiling cellular E3 ubiquitin ligase networks

Regulation of the Mevalonate Pathway by the Deubiquitinase USP28 in Squamous Cancer

Regulation of the ubiquitin ligase Ubr1 by the intrinsically disordered protein Roq1

Regulation of the ubiquitin ligase Ubr1 during protein quality control

The membrane trafficking protein myoferlin is a novel interactor of p97

The role of the proteasome in brown adipocyte development

Understanding ubiquitylation and FATylation by UBA6

Der Einfluss der Proteasomhemmung durch Bortezomib auf die Aktivierbarkeit humaner Thrombozyten

Die UBX-Domäne von UBXD1 organisiert die Ubiquitinbindung am C-Terminus der AAA-ATPase VCP/p97 zum proteasomalen Abbau

Dissecting the role of UBQLN2 in amyotrophic lateral sclerosis and frontotemporal dementia using multi-omics profiling

Exploring the Atypical Mechanisms of Protein Ubiquitination by Ariadne E3 Ligases

FAT10 and NUB1L cooperate to activate the 26S proteasome

Identification and functional characterization of the E2-conjugating enzyme UBE2QL1 in endolysosomal damage response

Identification of novel substrates of the Insoluble Protein Deposit (IPOD) in the yeast S. cerevisiae

Impact of proteostasis and the ubiquitin proteasome system on myeloid cell function in the CNS

Interactions driving Chaperone-assisted Assembly of Proteasome Core particles

Interplay between α-synuclein expression and 26S proteasome chaperone Rpn14 and Rpn11 deubiquitinase in the budding yeast Saccharomyces cerevisiae

Investigations into the interplay between the ubiquitin-like modifier FAT10 and the E3 ligases HUWE1 or CHIP

Mass spectrometry based analyses of posttranslational protein modification in bacterial and viral (co)-infection

SPATA2 regulates inflammation and cell death independently of CYLD

Towards a cell-biological understanding of the formation and dissociation of neurotoxic protein aggregates

Understanding the dual specificity of UBA6

USP22 controls tumorigenicity by regulating interferon responses and the stability of the tumor suppressor PML

Assembly pathway of the fungal COP9 signalosome

DPP9 substrates in DNA damage repair

Function of deubiquitylating enzymes in the selective degradation of plasma membrane proteins in Arabidopsis thaliana

Function of STAMBPL1 in Helicobacter pylori-associated cell death

Functional characterisation of de novo mutations in the PSMC5 gene carried by patients with the syndromic form of intellectual disability

Gezielter Proteinabbau in Pflanzen mittels chimärer E3-Ubiquitin-Ligasen

Metabolic Regulation of the Ubiquitin-Proteasome System

NEDD8 orchestrates active ubiquitylation assembly of cullin-RING E3 ligase

Primäre Osteoarthritis der Hand – Analyse anaboler und kataboler Knochenpathologien peripherer Gelenke mittels hochauflösendem CT Verfahren

Structural and functional characterization of GID/CTLH E3 ubiquitin ligases

Targeting the immunoproteasome and VCP/p97 in autoimmune disorders and viral infection

The Effect of Immunoproteasome Inhibition on T Helper Cells in Acute Inflammation

Die Proteinausstattung eines einzelnen pflanzlichen Mitochondriums

Characterization of the catalytic properties of the ubiquitin ligase E6AP

Diabetes Mellitus und der Einfluss auf die Protein-Qualitäts-Kontrolle sowie auf den Abbau des sarkomerischen Proteins Titin in der Skelettmuskulatur

Die Bedeutung des Immunoproteasoms und Inflammasoms bei Asthma bronchiale im Kindesalter : Studien zum „Bauernhofeffekt“ im weltweiten Vergleich

Novel insights into FAT10 biology : Parkin as the first FAT10-E3 ligase and the regulation of FAT10 activity by phosphorylation

Untersuchungen zum Einfluss von Nitrofettsäuren auf das Ubiquitin-Proteasom-System in Tumorzellen

Einfluss eines dysfunktionalen UCH-L1-Enzyms auf die podozytäre Proteostase in der Membranösen Nephropathie

Protein quality control systems in muscle : From disease to mechanism

Strukturbasiertes Design, Synthese und pharmakologische Evaluation von Proteasom- und FLT3-Inhibitoren in Leukämiemodellen

Untersuchungen zur Synthese von Macyranon A : Pd-katalysierte allylische Alkylierung von o-Hydroxyphenylketonen

Veränderungen des Ubiquitin-Proteasom-Systems im humanen Myokard bei ischämischer und dilatativer Kardiomyopathie