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G-Protein gekoppelter Rezeptor

Rezeptor

Subject heading	G-Protein gekoppelter Rezeptor
Synonym	G-Protein gekoppelte Rezeptoren GPCR
Broader term	Rezeptor
Topic	Biochemie, Biophysik, Zytologie
Source	Lex. Biol. 1999
Record type	Nomenklatur (Biologie / Chemie)
GND-Identifier	7723480-7
Record ID	1008155047
Topic of show all Development of Molecular Tools Targeting the Intracellular Allosteric Binding Site (IABS) of Chemokine Receptors Dynamics of arrestin interactions with G protein-coupled receptors and membrane Adhesion G protein-coupled receptors in adipocytes and their functional relevance Characterization of the role and relevance of mas-related G protein-coupled receptor X2 expression in the skin of patients with mycosis fungoides Design of innovative biosensors to monitor structural dynamics of GPCR activation and spatiotemporal signaling Determination of ligand-induced GPCR function by luminescence-based assays Modulation of GPCR function by their biophysical environment: effect of osmotic swelling and cellular cytoskeleton on β-adrenergic receptor signaling Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling Proximity-based screening of a class A/B hybrid G protein-coupled receptor Synthesis and binding affinity evaluation of new bitopic ligands of the mu opioid receptor (MOR) The role of orphan G-protein-coupled receptor GPR153 in the vascular damage response The role of the Adhesion GPCRs ADGRL1/LPHN1 and ADGRF5/GPR116 in metabolic homeostasis Characterization of human Neuropsin (hOPN5) and development of new mutants for optogenetic stimulation of the Gq signaling cascade Characterization of the novel adhesion G protein-coupled receptors: CG11318/mayo and CG15556/ketchup in Drosophila melanogaster Computational Studies of Ligand Efficacy and Binding in G-protein Coupled Receptors Development of barcoded GPCR assays to assess the effects of neuroleptics for brain disorders in living cells G protein-coupled receptors mobilize intracellular calcium via the Gs-βγ-PLCβ module GPR68 : A Proton Sensing G Protein-Coupled Receptor Mechanistic Characterization and Development of Tailored Small Molecule Modulators of the κ-Opioid Receptor Nanodelivery: a novel approach to transfer cell-free expressed GPCRs into live cells On the enigmatic mechanism of signal transduction of "arrestin-biased" angiotensin peptides: spotlight on endogenous angiotensin 1-7 role of GRK specificity and GPCR domains in differential receptor-arrestin interaction Role of the G Protein-coupled Receptor 17 and the GPR17+NG2-glia in the adult brain under physiological conditions Synthesis and pharmacological characterization of bivalent and fluorescent ligands to detect receptor dimerization for the D2-H3 heteromer Synthesis and pharmacological characterization of bivalent ligands for the D1-H3 receptor heteromer and fluorescent ligands for the D1 and H3 receptors Targeting the Intracellular Allosteric Binding Site (IABS) of G Protein-Coupled Receptors (GPCRs) The identification and characterization of GPCRs involved in adipose tissue (patho)physiology The molecular role of the adhesion GPCR ADGRV1 in brain astrocytes Assays and ligands for underexplored membrane proteins with potential as future drug targets Charakterisierung der Agonistenspezifität am Nucleotidrezeptors P2Y6 Charakterisierung der Expression des Orphan-Rezeptors GPR98 in normalen und neoplastischen humanen Geweben mit Hilfe eines neuen Antikörpers Charakterisierung der Lphn2- und Lphn3-Expression in genetisch veränderten Reporter-Mäusen Computational studies on δ-branch G protein-coupled P2Y and related orphan receptors Converting the elusive G protein-coupled adenosine A3 receptor into a highly-stable, well-characterized receptor model for structural studies Determinierung funktioneller Unterschiede der Interaktion von G-Proteinen mit den Mitgliedern der RH-RhoGEF-Familie Development and Synthesis of Novel Tool Compounds for Life Sciences Die Rolle des Adhäsions-GPCR VLGR1/ADGRV1 in Mitochondrien-assoziierten ER-Membranen GPR55-vermittelte anti-inflammatorische und anti-oxidative Effekte der Cumarin-Derivate KIT C und KIT H in IL-1b stimulierten SK-N-SH Zellen Heterologous production and characterization of selected G-protein-coupled receptors and G-proteins for structural and functional studies Identification and characterization of an NPYhomologous system in the nematode Caenorhabditis elegans Modulation of parathyroid hormone 1 receptor (PTH1R) signaling by receptor activity-modifying proteins (RAMPs) New insights into non-canonical desensitization of Gq signaling by GRK2/3 expression levels Optimized design and in vivo application of optogenetically modified Drosophila dopamine receptors to elucidate endogenous functions The Impact of Heterogenous Cell Populations on Impedance-Based Cell Analysis X-Ray Crystallography of G Protein-coupled Receptors : Exploring Interactions with Drug Molecules Development of radioligand binding and functional assays for the characterization of dopamine D2-like receptor ligands Functional Evaluation of Dopamine D2 Receptor Homo- and Heterodimers Localization and Trafficking of CXCR4 and CXCR7 Molekulare Charakterisierung der Liganden spezifischen Spannungsabhängigkeit der Opioid-Rezeptoren Receptor-mediated activation and pharmacological inhibition of heterotrimeric G proteins Synthese und Charakterisierung von Location Biased Liganden für µ-Opioid und β-Adrenerge Rezeptoren Understanding the Dynamics of G Protein-coupled Receptors and GPCR-Ligand Interactions using Computational Chemistry Methods Untersuchung zur Ausprägung der Latrophiline in der Lunge unter besonderer Berücksichtigung des Asthmakandidatengens Lphn3 Untersuchungen zur Bedeutung von im Rahmen einer genomweiten Sepsis-Assoziationsstudie identifizierten genetischen Varianten für die intrazelluläre Signaltransduktion Differenzierte β-Arrestin2 Rekrutierung am μ-Opioid Rezeptor durch klinisch eingesetzte Opioide Synthesis, optimization, and characterization of chromen-4-one and 1,7-phenanthroline derivatives as ligands for the orphan G protein-coupled receptors 35 and 84 Untersuchung der Autoreaktivität gegen G-Protein-gekoppelte Rezeptoren bei Patienten mit systemischer Sklerodermie Wirkung von Autoantikörpern gegen G-Protein-gekoppelte Rezeptoren auf die Sekretion von VEGF-A in HMECs Charakterisierung der physiologischen Funktionen des Latrophilin-Homologes LAT-1 in der Reproduktion von C. elegans Konformationsänderungen mechanosensitiver G-Protein gekoppelter Rezeptoren mittels intramolekularem dynamischem FRET

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Katalog der Deutschen Nationalbibliothek

G-Protein gekoppelter Rezeptor

Development of Molecular Tools Targeting the Intracellular Allosteric Binding Site (IABS) of Chemokine Receptors

Dynamics of arrestin interactions with G protein-coupled receptors and membrane

Adhesion G protein-coupled receptors in adipocytes and their functional relevance

Characterization of the role and relevance of mas-related G protein-coupled receptor X2 expression in the skin of patients with mycosis fungoides

Design of innovative biosensors to monitor structural dynamics of GPCR activation and spatiotemporal signaling

Determination of ligand-induced GPCR function by luminescence-based assays

Modulation of GPCR function by their biophysical environment: effect of osmotic swelling and cellular cytoskeleton on β-adrenergic receptor signaling

Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling

Proximity-based screening of a class A/B hybrid G protein-coupled receptor

Synthesis and binding affinity evaluation of new bitopic ligands of the mu opioid receptor (MOR)

The role of orphan G-protein-coupled receptor GPR153 in the vascular damage response

The role of the Adhesion GPCRs ADGRL1/LPHN1 and ADGRF5/GPR116 in metabolic homeostasis

Characterization of human Neuropsin (hOPN5) and development of new mutants for optogenetic stimulation of the Gq signaling cascade

Characterization of the novel adhesion G protein-coupled receptors: CG11318/mayo and CG15556/ketchup in Drosophila melanogaster

Computational Studies of Ligand Efficacy and Binding in G-protein Coupled Receptors

Development of barcoded GPCR assays to assess the effects of neuroleptics for brain disorders in living cells

G protein-coupled receptors mobilize intracellular calcium via the Gs-βγ-PLCβ module

GPR68 : A Proton Sensing G Protein-Coupled Receptor

Mechanistic Characterization and Development of Tailored Small Molecule Modulators of the κ-Opioid Receptor

Nanodelivery: a novel approach to transfer cell-free expressed GPCRs into live cells

On the enigmatic mechanism of signal transduction of "arrestin-biased" angiotensin peptides: spotlight on endogenous angiotensin 1-7

role of GRK specificity and GPCR domains in differential receptor-arrestin interaction

Role of the G Protein-coupled Receptor 17 and the GPR17+NG2-glia in the adult brain under physiological conditions

Synthesis and pharmacological characterization of bivalent and fluorescent ligands to detect receptor dimerization for the D2-H3 heteromer

Synthesis and pharmacological characterization of bivalent ligands for the D1-H3 receptor heteromer and fluorescent ligands for the D1 and H3 receptors

Targeting the Intracellular Allosteric Binding Site (IABS) of G Protein-Coupled Receptors (GPCRs)

The identification and characterization of GPCRs involved in adipose tissue (patho)physiology

The molecular role of the adhesion GPCR ADGRV1 in brain astrocytes

Assays and ligands for underexplored membrane proteins with potential as future drug targets

Charakterisierung der Agonistenspezifität am Nucleotidrezeptors P2Y6

Charakterisierung der Expression des Orphan-Rezeptors GPR98 in normalen und neoplastischen humanen Geweben mit Hilfe eines neuen Antikörpers

Charakterisierung der Lphn2- und Lphn3-Expression in genetisch veränderten Reporter-Mäusen

Computational studies on δ-branch G protein-coupled P2Y and related orphan receptors

Converting the elusive G protein-coupled adenosine A3 receptor into a highly-stable, well-characterized receptor model for structural studies

Determinierung funktioneller Unterschiede der Interaktion von G-Proteinen mit den Mitgliedern der RH-RhoGEF-Familie

Development and Synthesis of Novel Tool Compounds for Life Sciences

Die Rolle des Adhäsions-GPCR VLGR1/ADGRV1 in Mitochondrien-assoziierten ER-Membranen

GPR55-vermittelte anti-inflammatorische und anti-oxidative Effekte der Cumarin-Derivate KIT C und KIT H in IL-1b stimulierten SK-N-SH Zellen

Heterologous production and characterization of selected G-protein-coupled receptors and G-proteins for structural and functional studies

Identification and characterization of an NPYhomologous system in the nematode Caenorhabditis elegans

Modulation of parathyroid hormone 1 receptor (PTH1R) signaling by receptor activity-modifying proteins (RAMPs)

New insights into non-canonical desensitization of Gq signaling by GRK2/3 expression levels

Optimized design and in vivo application of optogenetically modified Drosophila dopamine receptors to elucidate endogenous functions

The Impact of Heterogenous Cell Populations on Impedance-Based Cell Analysis

X-Ray Crystallography of G Protein-coupled Receptors : Exploring Interactions with Drug Molecules

Development of radioligand binding and functional assays for the characterization of dopamine D2-like receptor ligands

Functional Evaluation of Dopamine D2 Receptor Homo- and Heterodimers

Localization and Trafficking of CXCR4 and CXCR7

Molekulare Charakterisierung der Liganden spezifischen Spannungsabhängigkeit der Opioid-Rezeptoren

Receptor-mediated activation and pharmacological inhibition of heterotrimeric G proteins

Synthese und Charakterisierung von Location Biased Liganden für µ-Opioid und β-Adrenerge Rezeptoren

Understanding the Dynamics of G Protein-coupled Receptors and GPCR-Ligand Interactions using Computational Chemistry Methods

Untersuchung zur Ausprägung der Latrophiline in der Lunge unter besonderer Berücksichtigung des Asthmakandidatengens Lphn3

Untersuchungen zur Bedeutung von im Rahmen einer genomweiten Sepsis-Assoziationsstudie identifizierten genetischen Varianten für die intrazelluläre Signaltransduktion

Differenzierte β-Arrestin2 Rekrutierung am μ-Opioid Rezeptor durch klinisch eingesetzte Opioide

Synthesis, optimization, and characterization of chromen-4-one and 1,7-phenanthroline derivatives as ligands for the orphan G protein-coupled receptors 35 and 84

Untersuchung der Autoreaktivität gegen G-Protein-gekoppelte Rezeptoren bei Patienten mit systemischer Sklerodermie

Wirkung von Autoantikörpern gegen G-Protein-gekoppelte Rezeptoren auf die Sekretion von VEGF-A in HMECs

Charakterisierung der physiologischen Funktionen des Latrophilin-Homologes LAT-1 in der Reproduktion von C. elegans

Konformationsänderungen mechanosensitiver G-Protein gekoppelter Rezeptoren mittels intramolekularem dynamischem FRET