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Michael Boutros

Name	Michael Boutros
Place	Mannheim (Wirkungsort) Heidelberg (Wirkungsort) Deutschland
Academic degree	Prof. Dr. rer. nat.
Related	Deutsches Krebsforschungszentrum Universität Heidelberg. Medizinische Fakultät Mannheim (Lehrbeauftragter) (2007-)
Further information	Heidelberg, Univ., Diss., 1999; Leiter der Arbeitsgruppe "Division of Signaling and Functional Genomics" am Deutschen Krebsforschungszentrum; seit September 2008 Ordinarius, Lehrstuhl für Zell- und Molekularbiologie an der Medizinischen Fakultät Mannheim der Universität Heidelberg; Prodekan des Dekanats der Medizinischen Fakultät Mannheim; Direktor des Forschungsbereichs Zell- und Molekularbiologie am CBTM der Medizinischen Fakultät Mannheim der Universität Heidelberg
Record type	Person
GND-Identifier	1023031132
Record ID	1023031132
Involved in show all The origin and evolution of Wnt signalling Nascent proteome analysis of MAPK and PI3K-AKT-mTOR oncogenic signaling pathways A genome-wide RNAi screen for genes important for proliferation of cultured Drosophila cells at low temperature identifies the Ball/VRK protein kinase A novel and flexible in vivo mouse modeling platform for sarcoma Characterization of cell-type-specific responses to doxorubicin treatment in murine breast cancer organoids using a single-cell multi-omics approach Metabolic balance in colorectal cancer is maintained by optimal Wnt signaling levels Characterization of anti-proliferative effects of YM155 in colorectal cancer subtypes Chronic Lymphocytic Leukaemia and the Tumour Microenvironment: A multi-omics investigation of interactions between genetic aberrations and external signals and their impact on drug response and clinical outcomes Drug interactions and response in patient-derived colorectal cancer organoids Elucidating the Functional Relevance of BAP1 in the Liver Large-scale mapping of chemical-genetic interaction phenotypes in human cells Targeting high-risk pediatric brain tumor entities Investigating the role of Evi in mouse embryo mesoderm segmentation The discovery of genes that exhibit strong effects on metastatic pancreatic cancer Ubiquitin-dependent regulation of the WNT cargo protein EVI/WLS Validation and characterization of MEK inhibitor induced Wnt signaling in colorectal cancer cell lines Genome-scale CRISPR screening at high sensitivity with an empirically designed sgRNA library gscreend: modelling asymmetric count ratios in CRISPR screens to decrease experiment size and improve phenotype detection Ageing, metabolism and the intestine A functional genomic screen for canonical Wnt signaling modulators MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer Rab-mediated membrane trafficking systems in terminal tracheal cells of Drosophila melanogaster A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment β-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells ERAD‐dependent control of the Wnt secretory factor Evi Systematic characterization of pan‐cancer mutation clusters Toward an integrated map of genetic interactions in cancer cells A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment Epigenetische und funktionelle Analyse des Tumorsuppressorkandidaten 3 (TUSC3) im kolorektalen Karzinom Patient derived γ-retroviral integration sites reveal active gene-regulatory regions in human repopulating long-term hematopoietic stem cells The role and regulation of the tryptophan degrading enzyme indoleamine-2,3-dioxygenase 1 in human breast cancer Systematic epistatic mapping of cellular processes The cardiac microenvironment uses non‐canonical WNT signaling to activate monocytes after myocardial infarction Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks The lncRNA VELUCT strongly regulates viability of lung cancer cells despite its extremely low abundance The long non-coding RNA LINC00152 is essential for cell cycle progression through mitosis in HeLa cells The long non-coding RNA LINC00152 is essential for cell cycle progression through mitosis in HeLa cells The role of anti-apoptotic Bcl-2 proteins for colorectal cancer development and progression CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries eIF 4A inactivates TORC 1 in response to amino acid starvation A chemical–genetic interaction map of small molecules using high‐throughput imaging in cancer cells Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity A synthetic lethal screen identifies FAT 1 as an antagonist of caspase‐8 in extrinsic apoptosis A novel phenotypic dissimilarity method for image-based high-throughput screens The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis Systematic approaches to dissect biological processes in stem cells by image‐based screening Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi LGR4 and LGR5 are R‐spondin receptors mediating Wnt/β‐catenin and Wnt/PCP signalling Design and evaluation of genome-wide libraries for RNA interference screens Identification of JAK/STAT pathway Regulators : Insights from RNAi screens Identification of JAK/STAT signalling components by genome-wide RNA interference Dishevelled mediates specificity in wnt-frizzled signaling pathways

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Katalog der Deutschen Nationalbibliothek

Michael Boutros

The origin and evolution of Wnt signalling

Nascent proteome analysis of MAPK and PI3K-AKT-mTOR oncogenic signaling pathways

A genome-wide RNAi screen for genes important for proliferation of cultured Drosophila cells at low temperature identifies the Ball/VRK protein kinase

A novel and flexible in vivo mouse modeling platform for sarcoma

Characterization of cell-type-specific responses to doxorubicin treatment in murine breast cancer organoids using a single-cell multi-omics approach

Metabolic balance in colorectal cancer is maintained by optimal Wnt signaling levels

Characterization of anti-proliferative effects of YM155 in colorectal cancer subtypes

Chronic Lymphocytic Leukaemia and the Tumour Microenvironment: A multi-omics investigation of interactions between genetic aberrations and external signals and their impact on drug response and clinical outcomes

Drug interactions and response in patient-derived colorectal cancer organoids

Elucidating the Functional Relevance of BAP1 in the Liver

Large-scale mapping of chemical-genetic interaction phenotypes in human cells

Targeting high-risk pediatric brain tumor entities

Investigating the role of Evi in mouse embryo mesoderm segmentation

The discovery of genes that exhibit strong effects on metastatic pancreatic cancer

Ubiquitin-dependent regulation of the WNT cargo protein EVI/WLS

Validation and characterization of MEK inhibitor induced Wnt signaling in colorectal cancer cell lines

Genome-scale CRISPR screening at high sensitivity with an empirically designed sgRNA library

gscreend: modelling asymmetric count ratios in CRISPR screens to decrease experiment size and improve phenotype detection

Ageing, metabolism and the intestine

A functional genomic screen for canonical Wnt signaling modulators

MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

Rab-mediated membrane trafficking systems in terminal tracheal cells of Drosophila melanogaster

A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment

β-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells

ERAD‐dependent control of the Wnt secretory factor Evi

Systematic characterization of pan‐cancer mutation clusters

Toward an integrated map of genetic interactions in cancer cells

A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment

Epigenetische und funktionelle Analyse des Tumorsuppressorkandidaten 3 (TUSC3) im kolorektalen Karzinom

Patient derived γ-retroviral integration sites reveal active gene-regulatory regions in human repopulating long-term hematopoietic stem cells

The role and regulation of the tryptophan degrading enzyme indoleamine-2,3-dioxygenase 1 in human breast cancer

Systematic epistatic mapping of cellular processes

The cardiac microenvironment uses non‐canonical WNT signaling to activate monocytes after myocardial infarction

Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks

The lncRNA VELUCT strongly regulates viability of lung cancer cells despite its extremely low abundance

The long non-coding RNA LINC00152 is essential for cell cycle progression through mitosis in HeLa cells

The long non-coding RNA LINC00152 is essential for cell cycle progression through mitosis in HeLa cells

The role of anti-apoptotic Bcl-2 proteins for colorectal cancer development and progression

CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries

eIF 4A inactivates TORC 1 in response to amino acid starvation

A chemical–genetic interaction map of small molecules using high‐throughput imaging in cancer cells

Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening

Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity

Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity

A synthetic lethal screen identifies FAT 1 as an antagonist of caspase‐8 in extrinsic apoptosis

A novel phenotypic dissimilarity method for image-based high-throughput screens

The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis

Systematic approaches to dissect biological processes in stem cells by image‐based screening

Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi

LGR4 and LGR5 are R‐spondin receptors mediating Wnt/β‐catenin and Wnt/PCP signalling

Design and evaluation of genome-wide libraries for RNA interference screens

Identification of JAK/STAT pathway Regulators : Insights from RNAi screens

Identification of JAK/STAT signalling components by genome-wide RNA interference

Dishevelled mediates specificity in wnt-frizzled signaling pathways