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Marcel Kool

Dozent

Name	Marcel Kool
Place	Wageningen (Studium) (Wirkungsort) Heidelberg (Wirkungsort) Deutschland
Gender	männlich
Academic degree	Dr.
Profession	Dozent (characteristic profession)
Related	Deutsches Krebsforschungszentrum (2011-) Universität Heidelberg. Medizinische Fakultät (Lehrbeauftragter) (2011-)
Further information	Forschungsschwerpunkt Funktionelle und strukturelle Genomenforschung; seit 2011 am Deutschen Krebsforschungszentrum Heidelberg und Lehrbeauftragter an der Medizinischen Fakultät der Universität Heidelberg
Record type	Person
GND-Identifier	1058669753
Record ID	1058669753
Involved in show all Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma Clinically unfavorable transcriptome subtypes of non-WNT/non-SHH medulloblastomas are associated with a predominance in proliferating and progenitor-like cell subpopulations Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort Patient‐ and xenograft‐derived organoids recapitulate pediatric brain tumor features and patient treatments Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours Group-specific cellular metabolism in Medulloblastoma CNS tumor with EP300::BCOR fusion: discussing its prevalence in adult population Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors ATRT–SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations Desmoplastic myxoid tumor, SMARCB1-mutant: clinical, histopathological and molecular characterization of a pineal region tumor encountered in adolescents and adults MYCN amplification drives an aggressive form of spinal ependymoma RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas Molecular progression of SHH-activated medulloblastomas Two molecularly distinct atypical teratoid/rhabdoid tumors (or tumor components) occurring in an infant with rhabdoid tumor predisposition syndrome 1 Identification and analyses of extra-cranial and cranial rhabdoid tumor molecular subgroups reveal tumors with cytotoxic T cell infiltration Molecular subgrouping of atypical teratoid/rhabdoid tumors: a reinvestigation and current consensus RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors A biobank of patient-derived pediatric brain tumor models Heterogeneity within the PF-EPN-B ependymoma subgroup Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas Author Correction: The landscape of genomic alterations across childhood cancers Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information Molecular characterization of medulloblastomas with extensive nodularity (MBEN) Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis Prognostic relevance of tumor-infiltrating lymphocytes and immune checkpoints in pediatric medulloblastoma The landscape of genomic alterations across childhood cancers DNA-methylation profiling discloses significant advantages over NanoString method for molecular classification of medulloblastoma Reduced histone H3 K27 trimethylation is encountered in about 50% of atypical teratoid/rhabdoid tumors (AT/RT) but is not associated with molecular subgroup status and outcome Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016 SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma New brain tumor entities emerge from molecular classification of CNS-PNETs Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma Somatostatin receptor subtype 2 (sst2) is a potential prognostic marker and a therapeutic target in medulloblastoma Signatures of mutational processes in human cancer Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma Dissecting the genomic complexity underlying medulloblastoma Biological and clinical heterogeneity of MYCN-amplified medulloblastoma

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Marcel Kool

Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma

Clinically unfavorable transcriptome subtypes of non-WNT/non-SHH medulloblastomas are associated with a predominance in proliferating and progenitor-like cell subpopulations

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

Patient‐ and xenograft‐derived organoids recapitulate pediatric brain tumor features and patient treatments

Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours

Group-specific cellular metabolism in Medulloblastoma

CNS tumor with EP300::BCOR fusion: discussing its prevalence in adult population

Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts

Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors

The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors

ATRT–SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance

Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome

Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors

Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation

Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors

Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis

Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations

Desmoplastic myxoid tumor, SMARCB1-mutant: clinical, histopathological and molecular characterization of a pineal region tumor encountered in adolescents and adults

MYCN amplification drives an aggressive form of spinal ependymoma

RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas

Molecular progression of SHH-activated medulloblastomas

Two molecularly distinct atypical teratoid/rhabdoid tumors (or tumor components) occurring in an infant with rhabdoid tumor predisposition syndrome 1

Identification and analyses of extra-cranial and cranial rhabdoid tumor molecular subgroups reveal tumors with cytotoxic T cell infiltration

Molecular subgrouping of atypical teratoid/rhabdoid tumors: a reinvestigation and current consensus

RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas

Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

A biobank of patient-derived pediatric brain tumor models

Heterogeneity within the PF-EPN-B ependymoma subgroup

Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

Author Correction: The landscape of genomic alterations across childhood cancers

Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information

Molecular characterization of medulloblastomas with extensive nodularity (MBEN)

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis

Prognostic relevance of tumor-infiltrating lymphocytes and immune checkpoints in pediatric medulloblastoma

The landscape of genomic alterations across childhood cancers

DNA-methylation profiling discloses significant advantages over NanoString method for molecular classification of medulloblastoma

Reduced histone H3 K27 trimethylation is encountered in about 50% of atypical teratoid/rhabdoid tumors (AT/RT) but is not associated with molecular subgroup status and outcome

Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016

SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors

The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants

FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

New brain tumor entities emerge from molecular classification of CNS-PNETs

Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

Somatostatin receptor subtype 2 (sst2) is a potential prognostic marker and a therapeutic target in medulloblastoma

Signatures of mutational processes in human cancer

Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma

Dissecting the genomic complexity underlying medulloblastoma

Biological and clinical heterogeneity of MYCN-amplified medulloblastoma