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Philipp Sievers

Name	Philipp Sievers
Place	Berlin (Geburtsort) Deutschland
Gender	männlich
Academic degree	PD Dr. med. (an der Medizinischen Fakultät der Universität Heidelberg) (2024, 2017)
Variant	Philipp Vincent Wilm Sievers
Related	Klinikum Heidelberg
Record type	Person
GND-Identifier	1075154790
Record ID	1075154790
Involved in show all Sarcoma classification by DNA methylation profiling Correlation between natural history and multi-omics profiling of meningiomas in NF2-related schwannomatosis suggests role of methylation group and immune microenvironment in tumor growth rate Loss over 5% of chromosome 1p is a clinically relevant and applicable cut-off for increased risk of recurrence in meningioma Identification of a putative molecular subtype of adult-type diffuse astrocytoma with recurrent MAPK pathway alterations A multi-institutional series of a novel, recurrent TRIM24::MET fusion-driven infant-type hemispheric glioma reveals significant clinico-pathological heterogeneity Clinically unfavorable transcriptome subtypes of non-WNT/non-SHH medulloblastomas are associated with a predominance in proliferating and progenitor-like cell subpopulations CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1 Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology Refinement of diagnostic criteria for pediatric-type diffuse high-grade glioma, IDH- and H3-wildtype, MYCN-subtype including histopathology, TP53, MYCN and ID2 status PLAG1 fusions extend the spectrum of PLAG(L)-altered CNS tumors Independent prognostic impact of DNA methylation class and chromosome 1p loss in WHO grade 2 and 3 meningioma undergoing adjuvant high-dose radiotherapy: comprehensive molecular analysis of EORTC 22042–26042 Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics Diagnostic accuracy of a minimal immunohistochemical panel in at/rt molecular subtyping, correlated to dna-methylation profiling Transcriptome analysis stratifies second-generation non-WNT/non-SHH medulloblastoma subgroups into clinically tractable subtypes A sellar presentation of a WNT-activated embryonal tumor: further evidence of an ectopic medulloblastoma Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology CNS neuroblastoma, FOXR2-activated and its mimics: a relevant panel approach for work-up and accurate diagnosis of this rare neoplasm Correction to: Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification CNS tumor with EP300::BCOR fusion: discussing its prevalence in adult population Comparison of transcriptome profiles between medulloblastoma primary and recurrent tumors uncovers novel variance effects in relapses Pediatric high-grade glioma MYCN is frequently associated with Li-Fraumeni syndrome Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification Gene expression profiling of Group 3 medulloblastomas defines a clinically tractable stratification based on KIRREL2 expression The dural angioleiomyoma harbors frequent GJA4 mutation and a distinct DNA methylation profile Rapid-CNS2: rapid comprehensive adaptive nanopore-sequencing of CNS tumors, a proof-of-concept study Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival A connectivity signature for glioblastoma [Abstract] Autonomous rhythmic activity in glioma networks drives brain tumour growth Epigenetic profiling reveals a subset of pediatric-type glioneuronal tumors characterized by oncogenic gene fusions involving several targetable kinases A novel SMARCA2-CREM fusion: expanding the molecular spectrum of intracranial mesenchymal tumors beyond the FET genes GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1 Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1 Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation Accurate calling of KIAA1549‐BRAF fusions from DNA of human brain tumours using methylation array‐based copy number and gene panel sequencing data Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1 Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis Response to trametinib treatment in progressive pediatric low-grade glioma patients CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas YAP1-fusions in pediatric NF2-wildtype meningioma Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker YAP1-fusions in pediatric NF2-wildtype meningioma Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1 Mutational patterns and regulatory networks in epigenetic subgroups of meningioma Molecular progression of SHH-activated medulloblastomas Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles

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Philipp Sievers

Sarcoma classification by DNA methylation profiling

Correlation between natural history and multi-omics profiling of meningiomas in NF2-related schwannomatosis suggests role of methylation group and immune microenvironment in tumor growth rate

Loss over 5% of chromosome 1p is a clinically relevant and applicable cut-off for increased risk of recurrence in meningioma

Identification of a putative molecular subtype of adult-type diffuse astrocytoma with recurrent MAPK pathway alterations

A multi-institutional series of a novel, recurrent TRIM24::MET fusion-driven infant-type hemispheric glioma reveals significant clinico-pathological heterogeneity

Clinically unfavorable transcriptome subtypes of non-WNT/non-SHH medulloblastomas are associated with a predominance in proliferating and progenitor-like cell subpopulations

CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas

A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1

Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow

Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Refinement of diagnostic criteria for pediatric-type diffuse high-grade glioma, IDH- and H3-wildtype, MYCN-subtype including histopathology, TP53, MYCN and ID2 status

PLAG1 fusions extend the spectrum of PLAG(L)-altered CNS tumors

Independent prognostic impact of DNA methylation class and chromosome 1p loss in WHO grade 2 and 3 meningioma undergoing adjuvant high-dose radiotherapy: comprehensive molecular analysis of EORTC 22042–26042

Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics

Diagnostic accuracy of a minimal immunohistochemical panel in at/rt molecular subtyping, correlated to dna-methylation profiling

Transcriptome analysis stratifies second-generation non-WNT/non-SHH medulloblastoma subgroups into clinically tractable subtypes

A sellar presentation of a WNT-activated embryonal tumor: further evidence of an ectopic medulloblastoma

Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions

Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

CNS neuroblastoma, FOXR2-activated and its mimics: a relevant panel approach for work-up and accurate diagnosis of this rare neoplasm

Correction to: Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification

CNS tumor with EP300::BCOR fusion: discussing its prevalence in adult population

Comparison of transcriptome profiles between medulloblastoma primary and recurrent tumors uncovers novel variance effects in relapses

Pediatric high-grade glioma MYCN is frequently associated with Li-Fraumeni syndrome

Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification

Gene expression profiling of Group 3 medulloblastomas defines a clinically tractable stratification based on KIRREL2 expression

The dural angioleiomyoma harbors frequent GJA4 mutation and a distinct DNA methylation profile

Rapid-CNS2: rapid comprehensive adaptive nanopore-sequencing of CNS tumors, a proof-of-concept study

Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival

A connectivity signature for glioblastoma [Abstract]

Autonomous rhythmic activity in glioma networks drives brain tumour growth

Epigenetic profiling reveals a subset of pediatric-type glioneuronal tumors characterized by oncogenic gene fusions involving several targetable kinases

A novel SMARCA2-CREM fusion: expanding the molecular spectrum of intracranial mesenchymal tumors beyond the FET genes

GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types

PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum

Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions

Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors

Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1

Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1

Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation

Accurate calling of KIAA1549‐BRAF fusions from DNA of human brain tumours using methylation array‐based copy number and gene panel sequencing data

Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas

PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum

Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors

Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1

Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis

Response to trametinib treatment in progressive pediatric low-grade glioma patients

CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas

YAP1-fusions in pediatric NF2-wildtype meningioma

Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker

YAP1-fusions in pediatric NF2-wildtype meningioma

Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation

Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course

Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions

Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1

Mutational patterns and regulatory networks in epigenetic subgroups of meningioma

Molecular progression of SHH-activated medulloblastomas

Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles