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Michael Nassal

Molekularbiologe

Name	Michael Nassal
Place	Deutschland
Academic degree	Prof. Dr. rer. nat.
Profession	Molekularbiologe (characteristic profession)
Related	Universitätsklinikum Freiburg. Klinik für Innere Medizin II Chemie (Studienfach) Molekularbiologie (Thema)
Further information	Professur für Medizinische Molekularbiologie, Medizinische Fakultät der Universität Freiburg Habilitation für Molekularbiologie/Virologie, Biologische Fakultät der Universität Heidelberg
Record type	Person
GND-Identifier	1094904546
Record ID	1094904546
Involved in show all Arsenic trioxide impacts hepatitis B virus core nuclear localization and efficiently interferes with HBV infection Epitope-focused immunogens targeting the hepatitis C virus glycoproteins induce broadly neutralizing antibodies Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target Minimally trans-complementation-dependent HBV reporter vectors Molecular elucidation of drug-induced abnormal assemblies of the hepatitis B virus capsid protein by solid-state NMR Structural conservation of HBV-like capsid proteins over hundreds of millions of years despite the shift from non-enveloped to enveloped life-style Structural conservation of HBV-like capsid proteins over hundreds of millions of years despite the shift from non-enveloped to enveloped life-style SUMO modification of hepatitis B virus core mediates nuclear entry, promyelocytic leukemia nuclear body association, and efficient formation of covalently closed circular DNA A 33-residue peptide tag increases solubility and stability of Escherichia coli produced single-chain antibody fragments Fast Magic‐Angle‐Spinning NMR Reveals the Evasive Hepatitis B Virus Capsid C‐Terminal Domain Fast Magic‐Angle‐Spinning NMR Reveals the Evasive Hepatitis B Virus Capsid C‐Terminal Domain A 33-residue peptide tag increases solubility and stability of Escherichia coli produced single-chain antibody fragments Fast magic‐angle‐spinning NMR reveals the evasive hepatitis B virus capsid C‐terminal domain** Pharmacomodulation of a ligand targeting the HBV capsid hydrophobic pocket Phosphorylation of the Hepatitis B Virus large envelope protein Relaxing the restricted structural dynamics in the human hepatitis B virus RNA encapsidation signal enables replication initiation in vitro Biomolecular solid-state NMR spectroscopy at 1200 MHz: the gain in resolution A pocket-factor–triggered conformational switch in the hepatitis B virus capsid A pocket-factor–triggered conformational switch in the hepatitis B virus capsid Biomolecular solid-state NMR spectroscopy at 1200 MHz : the gain in resolution Biomolecular solid-state NMR spectroscopy at 1200 MHz: the gain in resolution Hepatitis B virus–host interactions and novel targets for viral cure The Hepatitis B virus nucleocapsid - dynamic compartment for infectious virus production and new antiviral target A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability Solid-state NMR for studying the structure and dynamics of viral assemblies Untersuchungen zur Proteom-basierten Aufklärung einer durch Adenovirus 5 E4orf6 Protein vermittelten Interferenz mit der Hepadnavirus Replikation 100 kHz MAS proton-detected NMR spectroscopy of Hepatitis B virus capsids Combining cell-free protein synthesis and NMR into a tool to study capsid assembly modulation Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load Phosphorylation and alternative translation on wheat germ cell-free protein synthesis of the DHBV large envelope protein Solid-state [13C–15N] NMR resonance assignment of hepatitis B virus core protein Localizing Conformational Hinges by NMR: Where Do Hepatitis B Virus Core Proteins Adapt for Capsid Assembly? Strukturelle Untersuchung subviraler Partikel durch die Kombination von zellfreier Proteinherstellung mit 110 kHz MAS‐NMR‐Spektroskopie Structural Studies of Self‐Assembled Subviral Particles: Combining Cell‐Free Expression with 110 kHz MAS NMR Spectroscopy A novel hepatitis B virus species discovered in capuchin monkeys sheds new light on the evolution of primate hepadnaviruses Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure A role for the host DNA damage response in Hepatitis B virus cccDNA formation - and beyond? Few basepairing-independent motifs in the apical half of the avian HBV ε RNA stem-loop determine site-specific initiation of protein-priming Funktionelle und strukturelle Rolle der basischen C-terminalen Nukleinsäurebindungsdomäne des Hepatitis B Virus Coreproteins hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein ligase In vitro Rekonstitution der Replikationsinitiation des humanen Hepatitis B Virus Soluble cysteine-rich tick saliva proteins Salp15 and Iric-1 fromE. coli<br> Whole-chain tick saliva proteins presented on hepatitis B virus capsid-like particles induce high-titered antibodies with neutralizing potential Human hepatitis B virus production in avian cells is characterized by enhanced RNA splicing and the presence of capsids containing shortened genomes Recombinant fluorescent myristoylated PreS-containing Hepatitis B virus capsid- like particles = Rekombinante fluoreszierende und myristoylierte PreS-tragende Hepatitis B Virus Kapsidähnliche Partikel A fusion product of the complete Borrelia burgdorferi outer surface protein A (OspA) and the hepatitis B virus capsid protein is highly immunogenic and induces protective immunity similar to that seen with an effective lipidated OspA vaccine formula Die Synthese photolabiler Antamanid-Analoga und ihre Anwendung zur Photoaffinitätsmarkierung eines Rezeptors in der Leberzellmembran

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Katalog der Deutschen Nationalbibliothek

Michael Nassal

Arsenic trioxide impacts hepatitis B virus core nuclear localization and efficiently interferes with HBV infection

Epitope-focused immunogens targeting the hepatitis C virus glycoproteins induce broadly neutralizing antibodies

Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure

Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target

Minimally trans-complementation-dependent HBV reporter vectors

Molecular elucidation of drug-induced abnormal assemblies of the hepatitis B virus capsid protein by solid-state NMR

Structural conservation of HBV-like capsid proteins over hundreds of millions of years despite the shift from non-enveloped to enveloped life-style

Structural conservation of HBV-like capsid proteins over hundreds of millions of years despite the shift from non-enveloped to enveloped life-style

SUMO modification of hepatitis B virus core mediates nuclear entry, promyelocytic leukemia nuclear body association, and efficient formation of covalently closed circular DNA

A 33-residue peptide tag increases solubility and stability of Escherichia coli produced single-chain antibody fragments

Fast Magic‐Angle‐Spinning NMR Reveals the Evasive Hepatitis B Virus Capsid C‐Terminal Domain **

Fast Magic‐Angle‐Spinning NMR Reveals the Evasive Hepatitis B Virus Capsid C‐Terminal Domain **

A 33-residue peptide tag increases solubility and stability of Escherichia coli produced single-chain antibody fragments

Fast magic‐angle‐spinning NMR reveals the evasive hepatitis B virus capsid C‐terminal domain**

Pharmacomodulation of a ligand targeting the HBV capsid hydrophobic pocket

Phosphorylation of the Hepatitis B Virus large envelope protein

Relaxing the restricted structural dynamics in the human hepatitis B virus RNA encapsidation signal enables replication initiation in vitro

Biomolecular solid-state NMR spectroscopy at 1200 MHz: the gain in resolution

A pocket-factor–triggered conformational switch in the hepatitis B virus capsid

A pocket-factor–triggered conformational switch in the hepatitis B virus capsid

Biomolecular solid-state NMR spectroscopy at 1200 MHz : the gain in resolution

Biomolecular solid-state NMR spectroscopy at 1200 MHz: the gain in resolution

Hepatitis B virus–host interactions and novel targets for viral cure

The Hepatitis B virus nucleocapsid - dynamic compartment for infectious virus production and new antiviral target

A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability

Solid-state NMR for studying the structure and dynamics of viral assemblies

Untersuchungen zur Proteom-basierten Aufklärung einer durch Adenovirus 5 E4orf6 Protein vermittelten Interferenz mit der Hepadnavirus Replikation

100 kHz MAS proton-detected NMR spectroscopy of Hepatitis B virus capsids

Combining cell-free protein synthesis and NMR into a tool to study capsid assembly modulation

Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Phosphorylation and alternative translation on wheat germ cell-free protein synthesis of the DHBV large envelope protein

Solid-state [13C–15N] NMR resonance assignment of hepatitis B virus core protein

Localizing Conformational Hinges by NMR: Where Do Hepatitis B Virus Core Proteins Adapt for Capsid Assembly?

Strukturelle Untersuchung subviraler Partikel durch die Kombination von zellfreier Proteinherstellung mit 110 kHz MAS‐NMR‐Spektroskopie

Structural Studies of Self‐Assembled Subviral Particles: Combining Cell‐Free Expression with 110 kHz MAS NMR Spectroscopy

A novel hepatitis B virus species discovered in capuchin monkeys sheds new light on the evolution of primate hepadnaviruses

Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure

A role for the host DNA damage response in Hepatitis B virus cccDNA formation - and beyond?

Few basepairing-independent motifs in the apical half of the avian HBV ε RNA stem-loop determine site-specific initiation of protein-priming

Funktionelle und strukturelle Rolle der basischen C-terminalen Nukleinsäurebindungsdomäne des Hepatitis B Virus Coreproteins

hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein ligase

In vitro Rekonstitution der Replikationsinitiation des humanen Hepatitis B Virus

Soluble cysteine-rich tick saliva proteins Salp15 and Iric-1 fromE. coli<br>

Whole-chain tick saliva proteins presented on hepatitis B virus capsid-like particles induce high-titered antibodies with neutralizing potential

Human hepatitis B virus production in avian cells is characterized by enhanced RNA splicing and the presence of capsids containing shortened genomes

Recombinant fluorescent myristoylated PreS-containing Hepatitis B virus capsid- like particles = Rekombinante fluoreszierende und myristoylierte PreS-tragende Hepatitis B Virus Kapsidähnliche Partikel

A fusion product of the complete Borrelia burgdorferi outer surface protein A (OspA) and the hepatitis B virus capsid protein is highly immunogenic and induces protective immunity similar to that seen with an effective lipidated OspA vaccine formula

Die Synthese photolabiler Antamanid-Analoga und ihre Anwendung zur Photoaffinitätsmarkierung eines Rezeptors in der Leberzellmembran