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Peter Lichter (1957-)

Biologe

Name	Peter Lichter
Time	1957- (Date of birth and death)
Place	Mannheim (Geburtsort) Heidelberg (Wirkungsort) Deutschland
Gender	männlich
Academic degree	Prof. Dr.
Profession	Biologe (characteristic profession) Hochschullehrer
Variant	P. Lichter
Related	Klinikum Heidelberg Universität Heidelberg. Medizinische Fakultät Deutsche Akademie der Naturforscher Leopoldina (Mitglied, Matrikelnummer 06996) (2004-)
Further information	Leiter Molekulare Genetik, stellvertretender Geschäftsführender Direktor NCT Heidelberg, Universitätklinikum Heidelberg Deutsches Krebsforschungszentrum (DKFZ), Forschungsschwerpunkt Funktionelle und strukturelle Genomforschung, Molekulare Genetik
Record type	Person
GND-Identifier	1096366282
Record ID	1096366282
Involved in show all Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort scSNPdemux: a sensitive demultiplexing pipeline using single nucleotide polymorphisms for improved pooled single-cell RNA sequencing analysis Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors BCAT1 redox function maintains mitotic fidelity DNA fragility in murine neural progenitor cells : attempts to identify early replicating fragile sites and interrupt transcription activity Utilizing gene expression profiling, phosphoproteomics and loss-of-function screens to enhance the therapeutic efficacy of dasatinib in glioblastoma Characterization of the T-cell landscape and its functional role in Chronic Lymphocytic Leukemia EOMES and IL-10 regulate antitumor activity of T regulatory type 1 CD4+ T cells in chronic lymphocytic leukemia EOMES and IL-10 regulate antitumor activity of T regulatory type 1 CD4+ T cells in chronic lymphocytic leukemia Evidence for multi-copy Mega-NUMTs in the human genome Longitudinal analyses of CLL in mice identify leukemia-related clonal changes including a Myc gain predicting poor outcome in patients Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas Screen of Compounds to Target Tumor Cells with Chromothripsis Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype LifeTime and improving European healthcare through cell-based interceptive medicine Clonal Evolution Dynamics and Tumor Microenvironment Composition of Chronic Lymphocytic Leukemia Novel mode of action of the branched-chain amino acid transaminase BCAT1 in glioblastoma The landscape of viral associations in human cancers Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations TelomereHunter – in silico estimation of telomere content and composition from cancer genomes Molecular progression of SHH-activated medulloblastomas Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles Mismatch Repair Deficiency Drives Durable Complete Remission by Targeting Programmed Death Receptor 1 in a Metastatic Luminal Breast Cancer Patient Dissecting the prognostic significance and functional role of progranulin in chronic lymphocytic leukemia Dissecting the Prognostic Significance and Functional Role of Progranulin in Chronic Lymphocytic Leukemia Evolutionary trajectories of IDHWT glioblastomas reveal a common path of early tumorigenesis instigated years ahead of initial diagnosis Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks TBET‐expressing Th1 CD4+ T cells accumulate in chronic lymphocytic leukaemia without affecting disease progression in Eµ‐TCL1 mice Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors A biobank of patient-derived pediatric brain tumor models Control of chronic lymphocytic leukemia development by clonally-expanded CD8+ T-cells that undergo functional exhaustion in secondary lymphoid tissues Author Correction: BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation Author Correction: The landscape of genomic alterations across childhood cancers Molecular characterization of medulloblastomas with extensive nodularity (MBEN) Cited4 is a sex‐biased mediator of the antidiabetic glitazone response in adipocyte progenitors The landscape of genomic alterations across childhood cancers Branched‐chain ketoacids secreted by glioblastoma cells via MCT 1 modulate macrophage phenotype The whole-genome landscape of medulloblastoma subtypes New brain tumor entities emerge from molecular classification of CNS-PNETs Next-generation personalised medicine for high-risk paediatric cancer patients – the INFORM pilot study TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control Mechismo: predicting the mechanistic impact of mutations and modifications on molecular interactions Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the in cis downregulation of a gene cluster that targets NF-kB Hypermutation of the inactive X chromosome is a frequent event in cancer Signatures of mutational processes in human cancer Dissecting the genomic complexity underlying medulloblastoma Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing Biological and clinical heterogeneity of MYCN-amplified medulloblastoma CD24 Ala57Val polymorphism predicts pathologic complete response to sequential anthracycline- and taxane-based neoadjuvant chemotherapy for primary breast cancer Elastic SCAD as a novel penalization method for SVM classification tasks in high-dimensional data Oncogenic FAM131B–BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes Matrix-comparative genomic hybridization from multicenter formalin-fixed paraffin-embedded colorectal cancer tissue blocks

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Katalog der Deutschen Nationalbibliothek

Peter Lichter (1957-)

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

scSNPdemux: a sensitive demultiplexing pipeline using single nucleotide polymorphisms for improved pooled single-cell RNA sequencing analysis

Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis

The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors

BCAT1 redox function maintains mitotic fidelity

DNA fragility in murine neural progenitor cells : attempts to identify early replicating fragile sites and interrupt transcription activity

Utilizing gene expression profiling, phosphoproteomics and loss-of-function screens to enhance the therapeutic efficacy of dasatinib in glioblastoma

Characterization of the T-cell landscape and its functional role in Chronic Lymphocytic Leukemia

EOMES and IL-10 regulate antitumor activity of T regulatory type 1 CD4+ T cells in chronic lymphocytic leukemia

EOMES and IL-10 regulate antitumor activity of T regulatory type 1 CD4+ T cells in chronic lymphocytic leukemia

Evidence for multi-copy Mega-NUMTs in the human genome

Longitudinal analyses of CLL in mice identify leukemia-related clonal changes including a Myc gain predicting poor outcome in patients

Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas

Screen of Compounds to Target Tumor Cells with Chromothripsis

Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype

LifeTime and improving European healthcare through cell-based interceptive medicine

Clonal Evolution Dynamics and Tumor Microenvironment Composition of Chronic Lymphocytic Leukemia

Novel mode of action of the branched-chain amino acid transaminase BCAT1 in glioblastoma

The landscape of viral associations in human cancers

Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations

TelomereHunter – in silico estimation of telomere content and composition from cancer genomes

Molecular progression of SHH-activated medulloblastomas

Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma

Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles

Mismatch Repair Deficiency Drives Durable Complete Remission by Targeting Programmed Death Receptor 1 in a Metastatic Luminal Breast Cancer Patient

Dissecting the prognostic significance and functional role of progranulin in chronic lymphocytic leukemia

Dissecting the Prognostic Significance and Functional Role of Progranulin in Chronic Lymphocytic Leukemia

Evolutionary trajectories of IDHWT glioblastomas reveal a common path of early tumorigenesis instigated years ahead of initial diagnosis

Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma

Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks

TBET‐expressing Th1 CD4+ T cells accumulate in chronic lymphocytic leukaemia without affecting disease progression in Eµ‐TCL1 mice

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

A biobank of patient-derived pediatric brain tumor models

Control of chronic lymphocytic leukemia development by clonally-expanded CD8+ T-cells that undergo functional exhaustion in secondary lymphoid tissues

Author Correction: BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

Author Correction: The landscape of genomic alterations across childhood cancers

Molecular characterization of medulloblastomas with extensive nodularity (MBEN)

Cited4 is a sex‐biased mediator of the antidiabetic glitazone response in adipocyte progenitors

The landscape of genomic alterations across childhood cancers

Branched‐chain ketoacids secreted by glioblastoma cells via MCT 1 modulate macrophage phenotype

The whole-genome landscape of medulloblastoma subtypes

New brain tumor entities emerge from molecular classification of CNS-PNETs

Next-generation personalised medicine for high-risk paediatric cancer patients – the INFORM pilot study

TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus

Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing

DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control

Mechismo: predicting the mechanistic impact of mutations and modifications on molecular interactions

Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity

Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the in cis downregulation of a gene cluster that targets NF-kB

Hypermutation of the inactive X chromosome is a frequent event in cancer

Signatures of mutational processes in human cancer

Dissecting the genomic complexity underlying medulloblastoma

Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing

Biological and clinical heterogeneity of MYCN-amplified medulloblastoma

CD24 Ala57Val polymorphism predicts pathologic complete response to sequential anthracycline- and taxane-based neoadjuvant chemotherapy for primary breast cancer

Elastic SCAD as a novel penalization method for SVM classification tasks in high-dimensional data

Oncogenic FAM131B–BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma

Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes

Matrix-comparative genomic hybridization from multicenter formalin-fixed paraffin-embedded colorectal cancer tissue blocks