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Stefan Günther

Biologe

Name	Stefan Günther
Place	Freiburg im Breisgau (Wirkungsort) Deutschland
Academic degree	Prof. Dr.
Profession	Biologe (characteristic profession) Informatiker
Related	Albert-Ludwigs-Universität Freiburg. Pharmazeutische Bioinformatik Bioinformatik (Thema)
Further information	Professor für Pharmazeutische Bioinformatik
Record type	Person
GND-Identifier	1120625416
Record ID	1120625416
Involved in show all StreptomeDB 4.0: a comprehensive database of streptomycetes natural products enriched with protein interactions and interactive spectral visualization Development of a NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6 and CXCR1 Front Cover: Development of a NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6 and CXCR1 (ChemMedChem 20/2024) A 14-day double-blind, randomized, controlled crossover intervention study with anti-bacterial benzyl isothiocyanate from nasturtium (Tropaeolum majus) on human gut microbiome and host defense A 14-day double-blind, randomized, controlled crossover intervention study with anti-bacterial benzyl isothiocyanate from nasturtium (Tropaeolum majus) on human gut microbiome and host defense Development of a NanoBRET assay platform to detect intracellular ligands for the chemokine receptors CCR6 and CXCR1 Enzymatic S‐methylation of thiols catalyzed by different O‐methyltransferases How sensor Amt-like proteins integrate ammonium signals Structure of Escherichia coli cytochrome bd-II type oxidase with bound aurachin D Enzymatic S ‐Methylation of Thiols Catalyzed by Different O ‐Methyltransferases BC‐11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS‐CoV‐2 host cell entry Challenges in natural product-based drug discovery assisted within silico-based methods Design and synthesis of novel bisubstrate analogues of ppGpp containing diphosphate isosteres as potential RSH enzyme inhibitors HyperCys: a structure- and sequence-based predictor of hyper-reactive druggable cysteines Promotor-Enhancer-Interaktionen in humanen Herzmuskelzellen Recognition of functional relationships between biomedical concepts in the scientific literature using text mining and machine learning Using the CovPDB database as a basis for the HyperCys machine learning algorithm to simplify covalent drug design BC‐11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS‐CoV‐2 host cell entry Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells Assay development, hit identification and inhibitor optimization for epigenetic methyllysine reader domains Entwicklung und Implementierung eines Monte-Carlo-Verfahrens zur Simulation des Elektronentransfers in Proteinen Expediting small-molecule drug discovery through the integration of chemogenomics databases with predictive modeling Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells Mechanistic insights into the effects of empagliflozin in patients with type 2 diabetes and heart failure Respiratory complex I with charge symmetry in the membrane arm pumps protons Towards the prediction of non-peptidic epitopes Structural Basis for Inhibition of ROS‐Producing Respiratory Complex I by NADH‐OH Structural Basis for Inhibition of ROS‐Producing Respiratory Complex I by NADH‐OH Biosynthesis of the Tricyclic Aromatic Type II Polyketide Rishirilide: New Potential Third Ring Oxygenation after Three Cyclization Steps A chemoinformatic analysis of atoms, scaffolds and functional groups in natural products Applications of computational methods and African natural product databases to search for novel inhibitors of histone deacetylases ; [kumulative Dissertation] Biosynthesis of the tricyclic aromatic type II polyketide rishirilide: new potential third ring oxygenation after three cyclization steps Cooperative interaction of Nck and Lck orchestrates optimal TCR signaling Development of computational methods for ultra-large virtual screens Investigation and analysis on the biosynthesis of curacozole and foxicin Mechanismen der Zelltyp-spezifischen transkriptionellen Kontrolle durch den Mineralokortikoidrezeptor Natural products in Cyperus rotundus L. (Cyperaceae): an update of the chemistry and pharmacological activities SeMPI 2.0 - a web server for PKS and NRPS predictions combined with metabolite screening in natural product databases Structural basis for inhibition of ROS‐producing respiratory complex I by NADH‐OH Structure of Escherichia coli cytochrome bd-II type oxidase with bound aurachin D Author Correction: Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function Pharmacoinformatic Investigation of Medicinal Plants from East Africa Automated recognition of functional compound-protein relationships in literature Development of bioinformatic methods for the prediction and understanding of biosynthesis and activity of natural products Identifikation neuer Faktoren zur Stratifizierung von Akuten Myeloischen Leukämien mit indolentem oder aggressivem Verlauf Non-canonical binding of the LCK SH3 domain to CD3[epsilon] redefines initiation of TCR signaling and enhances CAR function = Non-canonical binding of LCK to the TCR Particulate matter (PM2.5) from biomass combustion induces an anti-oxidative response and cancer drug resistance in human bronchial epithelial BEAS-2B cells Pharmacoinformatic investigation of medicinal plants from East Africa StreptomeDB 3.0: an updated compendium of streptomycetes natural products Chromatin-Interaktionen in Kardiomyozyten Current computational methods for predicting protein interactions of natural products Development of inhibitors for the Bromodomain subfamilies I & IV and for the flavin site of the mitochondrial complex I using in silico fragment-based drug design Dynamik epigenetischer Signaturen und selektive Modulation regulatorischer Elemente in Kardiomyozyten KOFFI and Anabel 2.0 - a new binding kinetics database and its integration in an open-source binding analysis software New insights into the structural dynamics of the kinase JNK3 Computational analysis and manipulation of the metabolic network of drug producing microorganisms Development and application of ligand-based cheminformatics tools for drug discovery from natural products = Entwicklung und Anwendung von ligandenbasierten Cheminformatik-Programmen für die Identifizierung von Arzneimitteln aus Naturstoffen New insights into the structural dynamics of the kinase JNK3 CovPDB: a high-resolution coverage of the covalent protein–ligand interactome

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Katalog der Deutschen Nationalbibliothek

Stefan Günther

StreptomeDB 4.0: a comprehensive database of streptomycetes natural products enriched with protein interactions and interactive spectral visualization

Development of a NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6 and CXCR1

Front Cover: Development of a NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6 and CXCR1 (ChemMedChem 20/2024)

A 14-day double-blind, randomized, controlled crossover intervention study with anti-bacterial benzyl isothiocyanate from nasturtium (Tropaeolum majus) on human gut microbiome and host defense

A 14-day double-blind, randomized, controlled crossover intervention study with anti-bacterial benzyl isothiocyanate from nasturtium (Tropaeolum majus) on human gut microbiome and host defense

Development of a NanoBRET assay platform to detect intracellular ligands for the chemokine receptors CCR6 and CXCR1

Enzymatic S‐methylation of thiols catalyzed by different O‐methyltransferases

How sensor Amt-like proteins integrate ammonium signals

Structure of Escherichia coli cytochrome bd-II type oxidase with bound aurachin D

Enzymatic S ‐Methylation of Thiols Catalyzed by Different O ‐Methyltransferases

BC‐11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS‐CoV‐2 host cell entry

Challenges in natural product-based drug discovery assisted within silico-based methods

Design and synthesis of novel bisubstrate analogues of ppGpp containing diphosphate isosteres as potential RSH enzyme inhibitors

HyperCys: a structure- and sequence-based predictor of hyper-reactive druggable cysteines

Promotor-Enhancer-Interaktionen in humanen Herzmuskelzellen

Recognition of functional relationships between biomedical concepts in the scientific literature using text mining and machine learning

Using the CovPDB database as a basis for the HyperCys machine learning algorithm to simplify covalent drug design

BC‐11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS‐CoV‐2 host cell entry

Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells

Assay development, hit identification and inhibitor optimization for epigenetic methyllysine reader domains

Entwicklung und Implementierung eines Monte-Carlo-Verfahrens zur Simulation des Elektronentransfers in Proteinen

Expediting small-­molecule drug discovery through the integration of chemogenomics databases with predictive modeling

Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells

Mechanistic insights into the effects of empagliflozin in patients with type 2 diabetes and heart failure

Respiratory complex I with charge symmetry in the membrane arm pumps protons

Towards the prediction of non-peptidic epitopes

Structural Basis for Inhibition of ROS‐Producing Respiratory Complex I by NADH‐OH

Structural Basis for Inhibition of ROS‐Producing Respiratory Complex I by NADH‐OH

Biosynthesis of the Tricyclic Aromatic Type II Polyketide Rishirilide: New Potential Third Ring Oxygenation after Three Cyclization Steps

A chemoinformatic analysis of atoms, scaffolds and functional groups in natural products

Applications of computational methods and African natural product databases to search for novel inhibitors of histone deacetylases ; [kumulative Dissertation]

Biosynthesis of the tricyclic aromatic type II polyketide rishirilide: new potential third ring oxygenation after three cyclization steps

Cooperative interaction of Nck and Lck orchestrates optimal TCR signaling

Development of computational methods for ultra-large virtual screens

Investigation and analysis on the biosynthesis of curacozole and foxicin

Mechanismen der Zelltyp-spezifischen transkriptionellen Kontrolle durch den Mineralokortikoidrezeptor

Natural products in Cyperus rotundus L. (Cyperaceae): an update of the chemistry and pharmacological activities

SeMPI 2.0 - a web server for PKS and NRPS predictions combined with metabolite screening in natural product databases

Structural basis for inhibition of ROS‐producing respiratory complex I by NADH‐OH

Structure of Escherichia coli cytochrome bd-II type oxidase with bound aurachin D

Author Correction: Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function

Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function

Pharmacoinformatic Investigation of Medicinal Plants from East Africa

Automated recognition of functional compound-protein relationships in literature

Development of bioinformatic methods for the prediction and understanding of biosynthesis and activity of natural products

Identifikation neuer Faktoren zur Stratifizierung von Akuten Myeloischen Leukämien mit indolentem oder aggressivem Verlauf

Non-canonical binding of the LCK SH3 domain to CD3[epsilon] redefines initiation of TCR signaling and enhances CAR function = Non-canonical binding of LCK to the TCR

Particulate matter (PM2.5) from biomass combustion induces an anti-oxidative response and cancer drug resistance in human bronchial epithelial BEAS-2B cells

Pharmacoinformatic investigation of medicinal plants from East Africa

StreptomeDB 3.0: an updated compendium of streptomycetes natural products

Chromatin-Interaktionen in Kardiomyozyten

Current computational methods for predicting protein interactions of natural products

Development of inhibitors for the Bromodomain subfamilies I & IV and for the flavin site of the mitochondrial complex I using in silico fragment-based drug design

Dynamik epigenetischer Signaturen und selektive Modulation regulatorischer Elemente in Kardiomyozyten

KOFFI and Anabel 2.0 - a new binding kinetics database and its integration in an open-source binding analysis software

New insights into the structural dynamics of the kinase JNK3

Computational analysis and manipulation of the metabolic network of drug producing microorganisms

Development and application of ligand-based cheminformatics tools for drug discovery from natural products = Entwicklung und Anwendung von ligandenbasierten Cheminformatik-Programmen für die Identifizierung von Arzneimitteln aus Naturstoffen

New insights into the structural dynamics of the kinase JNK3

CovPDB: a high-resolution coverage of the covalent protein–ligand interactome

Expediting small-molecule drug discovery through the integration of chemogenomics databases with predictive modeling