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David Solomon

Name	David Solomon
Place	USA
Gender	männlich
Variant	David A. Solomon
Further information	Department of Pathology, University of California, San Francisco, USA
Record type	Person
GND-Identifier	1201775574
Record ID	1201775574
Involved in show all “De novo replication repair deficient glioblastoma, IDH-wildtype” is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade Somatic mosaic SOX10 indel mutations underlie a form of segmental schwannomatosis Loss of p16 expression is a sensitive marker of CDKN2A homozygous deletion in malignant meningiomas A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1 EWSR1-BEND2 fusion defines an epigenetically distinct subtype of astroblastoma Genetic and epigenetic characterization of posterior pituitary tumors Low-grade glioneuronal tumors with FGFR2 fusion resolve into a single epigenetic group corresponding to ‘Polymorphous low-grade neuroepithelial tumor of the young’ Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition Gliomas arising in the setting of Li-Fraumeni syndrome stratify into two molecular subgroups with divergent clinicopathologic features An update on the central nervous system manifestations of familial tumor predisposition syndromes Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma Primary intracranial sarcomas with DICER1 mutation often contain prominent eosinophilic cytoplasmic globules and can occur in the setting of neurofibromatosis type 1 Oligodendrogliomas, IDH-mutant and 1p/19q-codeleted, arising during teenage years often lack TERT promoter mutation that is typical of their adult counterparts The genetic landscape of gliomas arising after therapeutic radiation Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42 Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile The genetic landscape of ganglioglioma Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway Genetic confirmation that ependymoma can arise as part of multiple endocrine neoplasia type 1 (MEN1) syndrome

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David Solomon

“De novo replication repair deficient glioblastoma, IDH-wildtype” is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade

Somatic mosaic SOX10 indel mutations underlie a form of segmental schwannomatosis

Loss of p16 expression is a sensitive marker of CDKN2A homozygous deletion in malignant meningiomas

A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets

Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer

Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1

EWSR1-BEND2 fusion defines an epigenetically distinct subtype of astroblastoma

Genetic and epigenetic characterization of posterior pituitary tumors

Low-grade glioneuronal tumors with FGFR2 fusion resolve into a single epigenetic group corresponding to ‘Polymorphous low-grade neuroepithelial tumor of the young’

Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor

Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition

Gliomas arising in the setting of Li-Fraumeni syndrome stratify into two molecular subgroups with divergent clinicopathologic features

An update on the central nervous system manifestations of familial tumor predisposition syndromes

Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas

A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers

Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma

Primary intracranial sarcomas with DICER1 mutation often contain prominent eosinophilic cytoplasmic globules and can occur in the setting of neurofibromatosis type 1

Oligodendrogliomas, IDH-mutant and 1p/19q-codeleted, arising during teenage years often lack TERT promoter mutation that is typical of their adult counterparts

The genetic landscape of gliomas arising after therapeutic radiation

Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42

Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile

The genetic landscape of ganglioglioma

Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma

STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection

A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle

Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation

Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway

Genetic confirmation that ependymoma can arise as part of multiple endocrine neoplasia type 1 (MEN1) syndrome