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Frank Kirchhoff (1961-)

Facharzt für Mikrobiologie, Virologie und Infektionsepidemiologie

Name	Frank Kirchhoff
Time	1961- (Date of birth and death)
Place	Bückeburg (Geburtsort) Deutschland
Academic degree	Prof. Dr.
Profession	Facharzt für Mikrobiologie, Virologie und Infektionsepidemiologie (characteristic profession) Biologe Hochschullehrer
Related	Universität Ulm. Medizinische Fakultät Universitätsklinikum Erlangen Deutsche Akademie der Naturforscher Leopoldina (Mitglied, Matrikelnummer 7295) (2009-)
Source	https://www.uni-ulm.de/fileadmin/website_uni_ulm/nawi.coq/CV_Frank_Kirchhoff.pdf (Stand: 05.03.2024)
Record type	Person
GND-Identifier	120968940
Record ID	120968940
Involved in show all Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptors Retinol Binding Protein 4 reactivates latent HIV-1 by triggering canonical NF-κB, JAK/STAT5 and JNK signalling Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration Viral blips and hidden infections: pitfalls in HIV-1 prophylaxis by broadly neutralizing antibodies α-Synuclein fibrils enhance HIV-1 infection of human T cells, macrophages and microglia A naturally occurring 22-amino acid fragment of human hemoglobin A inhibits autophagy and HIV-1 A Gaussia luciferase reporter assay for the evaluation of coronavirus Nsp5/3CLpro activity RPLP1 restricts HIV-1 transcription by disrupting C/EBPβ binding to the LTR Replication competent HIV-guided CRISPR screen identifies antiviral factors including targets of the accessory protein Nef Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens Attenuated replication and damaging effects of SARS-CoV-2 Omicron variants in an intestinal epithelial barrier model Causes and Consequences of Coronavirus Spike Protein Variability Surface functionalization affects the retention and bio-distribution of orally administered mesoporous silica nanoparticles in a colitis mouse model ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling Determinants of species-specific utilization of ACE2 by human and animal coronaviruses The C-terminal 32-mer fragment of hemoglobin alpha is an amyloidogenic peptide with antimicrobial properties Clinical, Imaging, and Histopathological Features of Pulmonary Sequelae after Mild COVID-19 Endogenous IFITMs boost SARS-coronavirus 1 and 2 replication whereas overexpression inhibits infection by relocalizing ACE2 Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1 SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor Serum neutralizing capacity and T-cell response against the omicron BA.1 variant in seropositive children and their parents one year after SARS-CoV-2 infection Strong attenuation of SARS-CoV-2 Omicron BA.1 and increased replication of the BA.5 subvariant in human cardiomyocytes High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection SARS-CoV-2 infection and the brain: direct evidence for brain changes in milder cases Interferon antagonists encoded by SARS-CoV-2 at a glance BNT162b2 booster after heterologous prime-boost vaccination induces potent neutralizing antibodies and T cell reactivity against SARS-CoV-2 Omicron BA.1 in young adults Determinants of spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2 The transmembrane protease TMPRSS2 as a therapeutic target for COVID-19 treatment Modular Hydrogel−Mesoporous Silica Nanoparticle Constructs for Therapy and Diagnostics SARS-CoV-2 Nsp1: Ein kleines Protein blockiert die Immunantwort Increased in vitro Anti‐HIV Activity of Caffeinium‐Functionalized Polyoxometalates Supramolecular Peptide Nanofibrils with Optimized Sequences and Molecular Structures for Efficient Retroviral Transduction Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection An additional NF-kB site allows HIV-1 subtype C to evade restriction by nuclear PYHIN proteins CRISPA: a non-viral, transient Cas9 delivery system based on reengineered anthrax toxin HIV protease: late action to prevent immune detection IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro Increased in vitro anti‐HIV activity of caffeinium‐functionalized polyoxometalates Manipulation of autophagy by SARS-CoV-2 proteins Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling Spike residue 403 affects binding of coronavirus spikes to human ACE2 Spike residue 403 affects binding of coronavirus spikes to human ACE2 Supramolecular peptide nanofibrils with optimized sequences and molecular structures for efficient retroviral transduction Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities A placenta derived C-Terminal fragment of β-Hemoglobin with combined antibacterial and antiviral activity An improved method for high-throughput quantification of autophagy in mammalian cells An improved method for high-throughput quantification of autophagy in mammalian cells Cellular Factors Targeting HIV-1 Transcriptionand Viral RNA Transcripts Emerging role of PYHIN proteins as antiviral restriction factors HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner Nef-mediated CD3-TCR downmodulation dampens acute inflammation and promotes SIV immune evasion Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells SARS-CoV-2 Is restricted by zinc finger antiviral protein despite preadaptation to the low-CpG environment in humans Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2 A trip down memory lane with Retrovirology Guanylate-Binding proteins 2 and 5 exert broad antiviral activity by inhibiting Furin-Mediated processing of viral envelope proteins HIV-1 Vpu is a potent transcriptional suppressor of NF-kB-elicited antiviral immune responses Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3

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Katalog der Deutschen Nationalbibliothek

Frank Kirchhoff (1961-)

Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptors

Retinol Binding Protein 4 reactivates latent HIV-1 by triggering canonical NF-κB, JAK/STAT5 and JNK signalling

Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts

GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration

Viral blips and hidden infections: pitfalls in HIV-1 prophylaxis by broadly neutralizing antibodies

α-Synuclein fibrils enhance HIV-1 infection of human T cells, macrophages and microglia

A naturally occurring 22-amino acid fragment of human hemoglobin A inhibits autophagy and HIV-1

A Gaussia luciferase reporter assay for the evaluation of coronavirus Nsp5/3CLpro activity

RPLP1 restricts HIV-1 transcription by disrupting C/EBPβ binding to the LTR

Replication competent HIV-guided CRISPR screen identifies antiviral factors including targets of the accessory protein Nef

Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens

Attenuated replication and damaging effects of SARS-CoV-2 Omicron variants in an intestinal epithelial barrier model

Causes and Consequences of Coronavirus Spike Protein Variability

Surface functionalization affects the retention and bio-distribution of orally administered mesoporous silica nanoparticles in a colitis mouse model

ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling

Determinants of species-specific utilization of ACE2 by human and animal coronaviruses

The C-terminal 32-mer fragment of hemoglobin alpha is an amyloidogenic peptide with antimicrobial properties

Clinical, Imaging, and Histopathological Features of Pulmonary Sequelae after Mild COVID-19

Endogenous IFITMs boost SARS-coronavirus 1 and 2 replication whereas overexpression inhibits infection by relocalizing ACE2

Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1

SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor

Serum neutralizing capacity and T-cell response against the omicron BA.1 variant in seropositive children and their parents one year after SARS-CoV-2 infection

Strong attenuation of SARS-CoV-2 Omicron BA.1 and increased replication of the BA.5 subvariant in human cardiomyocytes

High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection

SARS-CoV-2 infection and the brain: direct evidence for brain changes in milder cases

Interferon antagonists encoded by SARS-CoV-2 at a glance

BNT162b2 booster after heterologous prime-boost vaccination induces potent neutralizing antibodies and T cell reactivity against SARS-CoV-2 Omicron BA.1 in young adults

Determinants of spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2

The transmembrane protease TMPRSS2 as a therapeutic target for COVID-19 treatment

Modular Hydrogel−Mesoporous Silica Nanoparticle Constructs for Therapy and Diagnostics

SARS-CoV-2 Nsp1: Ein kleines Protein blockiert die Immunantwort

Increased in vitro Anti‐HIV Activity of Caffeinium‐Functionalized Polyoxometalates

Supramolecular Peptide Nanofibrils with Optimized Sequences and Molecular Structures for Efficient Retroviral Transduction

Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection

An additional NF-kB site allows HIV-1 subtype C to evade restriction by nuclear PYHIN proteins

CRISPA: a non-viral, transient Cas9 delivery system based on reengineered anthrax toxin

HIV protease: late action to prevent immune detection

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro

Increased in vitro anti‐HIV activity of caffeinium‐functionalized polyoxometalates

Manipulation of autophagy by SARS-CoV-2 proteins

Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling

Spike residue 403 affects binding of coronavirus spikes to human ACE2

Spike residue 403 affects binding of coronavirus spikes to human ACE2

Supramolecular peptide nanofibrils with optimized sequences and molecular structures for efficient retroviral transduction

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

A placenta derived C-Terminal fragment of β-Hemoglobin with combined antibacterial and antiviral activity

An improved method for high-throughput quantification of autophagy in mammalian cells

An improved method for high-throughput quantification of autophagy in mammalian cells

Cellular Factors Targeting HIV-1 Transcriptionand Viral RNA Transcripts

Emerging role of PYHIN proteins as antiviral restriction factors

HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner

Nef-mediated CD3-TCR downmodulation dampens acute inflammation and promotes SIV immune evasion

Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells

SARS-CoV-2 Is restricted by zinc finger antiviral protein despite preadaptation to the low-CpG environment in humans

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

A trip down memory lane with Retrovirology

Guanylate-Binding proteins 2 and 5 exert broad antiviral activity by inhibiting Furin-Mediated processing of viral envelope proteins

HIV-1 Vpu is a potent transcriptional suppressor of NF-kB-elicited antiviral immune responses

Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity

Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3