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Albert Sickmann (1974-)

Ingenieur Biotechnologie

Name	Albert Sickmann
Time	1974- (Date of birth and death)
Place	Deutschland
Academic degree	Prof. Dr. rer. nat.
Profession	Ingenieur Biotechnologie (characteristic profession) Biochemiker Hochschullehrer
Related	Institut für Spektrochemie und Angewandte Spektroskopie (Professor für Bioanalytik) (2008-) Technische Universität Dortmund. Fakultät Bio- und Chemieingenieurwesen
Record type	Person
GND-Identifier	123207444
Record ID	123207444
Involved in show all Methylmalonic acidemia triggers lysosomal-autophagy dysfunctions Multi-phased Kinetics and Interaction of Protein Kinase Signaling in Glycoprotein VI-Induced Platelet αIIbβ3 Integrin Activation and Degranulation Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion Highly sensitive therapeutic drug monitoring of infliximab in serum by targeted mass spectrometry in comparison to ELISA data Multi-level profiling unravels mitochondrial dysfunction in myotonic dystrophy type 2 Multiple reaction monitoring assays for large-scale quantitation of proteins from 20 mouse organs and tissues Suppressed ORAI1-STIM1-dependent Ca2+ entry by protein kinase C isoforms regulating platelet procoagulant activity The challenges of research data management in cardiovascular science: a DGK and DZHK position paper - executive summary ComplexEye: a multi-lens array microscope for high-throughput embedded immune cell migration analysis The challenges of research data management in cardiovascular science: a DGK and DZHK position paper—executive summary Correction: A Homozygous PPP1R21 Splice Variant Associated with Severe Developmental Delay, Absence of Speech, and Muscle Weakness Leads to Activated Proteasome Function Periostin as a blood biomarker of muscle cell fibrosis, cardiomyopathy and disease severity in myotonic dystrophy type 1 A Homozygous PPP1R21 Splice Variant Associated with Severe Developmental Delay, Absence of Speech, and Muscle Weakness Leads to Activated Proteasome Function A Homozygous PPP1R21 Splice Variant Associated with Severe Developmental Delay, Absence of Speech, and Muscle Weakness Leads to Activated Proteasome Function Cyclophilin a is not acetylated at lysine-82 and lysine-125 in resting and stimulated platelets Effects of extracellular vesicles from osteogenic differentiated human BMSCs on osteogenic and adipogenic differentiation capacity of naïve human BMSCs ERK1/2 activity is critical for the outcome of ischemic stroke IFN-γ secretion of PBMC from non-drug-allergic control persons: Considerations for the validity of a positive lymphocyte transformation test Synthesis of aspartic proteases probes and their application for interaction identification and binding hotspots mapping The challenges of research data management in cardiovascular science : a DGK and DZHK position paper—executive summary Identification of herbal teas and their compounds eliciting antiviral activity against SARS-CoV-2 in vitro LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF‐κB to the nucleus Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles Proteome-Based Clustering Approaches Reveal Phylogenetic Insights into Amphistegina Electronic cigarette liquids impair metabolic cooperation and alter proteomic profiles in V79 cells Skeletal muscle provides the immunological micro-milieu for specific plasma cells in anti-synthetase syndrome-associated myositis The potential of remdesivir to affect function, metabolism and proliferation of cardiac and kidney cells in vitro Novel insights into PORCN mutations, associated phenotypes and pathophysiological aspects Cathepsin D as biomarker in CSF of nusinersen‐treated patients with spinal muscular atrophy Generation of a humanized FXII knock-in mouse-A powerful model system to test novel anti-thrombotic agents Homozygous WASHC4 variant in two sisters causes a syndromic phenotype defined by dysmorphisms, intellectual disability, profound developmental disorder, and skeletal muscle involvement Toward zero variance in proteomics sample preparation : positive-pressure FASP in 96-well format (PF96) enables highly reproducible, time- and cost-efficient analysis of sample cohorts Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity Protein signature of human skin fibroblasts allows the study of the molecular etiology of rare neurological diseases Assessment of a complete and classified platelet proteome from genome-wide transcripts of human platelets and megakaryocytes covering platelet functions First clinical and myopathological description of a myofibrillar myopathy with congenital onset and homozygous mutation in FLNC Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery Phenotypical and Myopathological Consequences of Compound Heterozygous Missense and Nonsense Variants in SLC18A3 Proteomics: A Tool to Study Platelet Function Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome Targeted Approach to Distinguish and Determine Absolute Levels of GDF8 and GDF11 in Mouse Serum Characterizing mitochondrial signaling networks by quantitative proteomics Impaired iloprost-induced platelet inhibition and phosphoproteome changes in patients with confirmed pseudohypoparathyroidism type Ia, linked to genetic mutations in GNAS Improving identification of in-organello protein-protein interactions using an affinity-enrichable, isotopically coded, and mass spectrometry-cleavable chemical crosslinker Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome Phosphoproteomic analysis of STRIPAK mutants identifies a conserved serine phosphorylation site in PAK kinase CLA4 to be important in fungal sexual development and polarized growth The STRIPAK signaling complex regulates dephosphorylation of GUL1, an RNA-binding protein that shuttles on endosomes Molecular biological elucidation of late tropane alkaloid biosynthesis Molecular phenotyping of laboratory mouse strains using 500 multiple reaction monitoring mass spectrometry plasma assays Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures Disentangling thermal stress responses in a reef-calcifier and its photosymbionts by shotgun proteomics Intersection of Proteomics and Genomics to “Solve the Unsolved” in Rare Disorders such as Neurodegenerative and Neuromuscular Diseases Dieter Klockow (1934 – 2018) Charakterisierung der Wechselwirkung post-translationaler Modifikationen mittels Massenspektrometrie-basierter Proteomforschung Tracking Effects of SIL1 Increase: Taking a Closer Look Beyond the Consequences of Elevated Expression Level DISMS2: A flexible algorithm for direct proteome- wide distance calculation of LC-MS/MS runs Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous delG frameshift mutations in ITGA2B Understanding platelets : Lessons from proteomics, genomics and promises from network analysis PeptideTracker: A knowledge base for collecting and storing information on protein concentrations in biological tissues Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic Archaea

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Katalog der Deutschen Nationalbibliothek

Albert Sickmann (1974-)

Methylmalonic acidemia triggers lysosomal-autophagy dysfunctions

Multi-phased Kinetics and Interaction of Protein Kinase Signaling in Glycoprotein VI-Induced Platelet αIIbβ3 Integrin Activation and Degranulation

Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion

Highly sensitive therapeutic drug monitoring of infliximab in serum by targeted mass spectrometry in comparison to ELISA data

Multi-level profiling unravels mitochondrial dysfunction in myotonic dystrophy type 2

Multiple reaction monitoring assays for large-scale quantitation of proteins from 20 mouse organs and tissues

Suppressed ORAI1-STIM1-dependent Ca2+ entry by protein kinase C isoforms regulating platelet procoagulant activity

The challenges of research data management in cardiovascular science: a DGK and DZHK position paper - executive summary

ComplexEye: a multi-lens array microscope for high-throughput embedded immune cell migration analysis

The challenges of research data management in cardiovascular science: a DGK and DZHK position paper—executive summary

Correction: A Homozygous PPP1R21 Splice Variant Associated with Severe Developmental Delay, Absence of Speech, and Muscle Weakness Leads to Activated Proteasome Function

Periostin as a blood biomarker of muscle cell fibrosis, cardiomyopathy and disease severity in myotonic dystrophy type 1

A Homozygous PPP1R21 Splice Variant Associated with Severe Developmental Delay, Absence of Speech, and Muscle Weakness Leads to Activated Proteasome Function

A Homozygous PPP1R21 Splice Variant Associated with Severe Developmental Delay, Absence of Speech, and Muscle Weakness Leads to Activated Proteasome Function

Cyclophilin a is not acetylated at lysine-82 and lysine-125 in resting and stimulated platelets

Effects of extracellular vesicles from osteogenic differentiated human BMSCs on osteogenic and adipogenic differentiation capacity of naïve human BMSCs

ERK1/2 activity is critical for the outcome of ischemic stroke

IFN-γ secretion of PBMC from non-drug-allergic control persons: Considerations for the validity of a positive lymphocyte transformation test

Synthesis of aspartic proteases probes and their application for interaction identification and binding hotspots mapping

The challenges of research data management in cardiovascular science : a DGK and DZHK position paper—executive summary

Identification of herbal teas and their compounds eliciting antiviral activity against SARS-CoV-2 in vitro

LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF‐κB to the nucleus

Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles

Proteome-Based Clustering Approaches Reveal Phylogenetic Insights into Amphistegina

Electronic cigarette liquids impair metabolic cooperation and alter proteomic profiles in V79 cells

Skeletal muscle provides the immunological micro-milieu for specific plasma cells in anti-synthetase syndrome-associated myositis

The potential of remdesivir to affect function, metabolism and proliferation of cardiac and kidney cells in vitro

Novel insights into PORCN mutations, associated phenotypes and pathophysiological aspects

Cathepsin D as biomarker in CSF of nusinersen‐treated patients with spinal muscular atrophy

Generation of a humanized FXII knock-in mouse-A powerful model system to test novel anti-thrombotic agents

Homozygous WASHC4 variant in two sisters causes a syndromic phenotype defined by dysmorphisms, intellectual disability, profound developmental disorder, and skeletal muscle involvement

Toward zero variance in proteomics sample preparation : positive-pressure FASP in 96-well format (PF96) enables highly reproducible, time- and cost-efficient analysis of sample cohorts

Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity

Protein signature of human skin fibroblasts allows the study of the molecular etiology of rare neurological diseases

Assessment of a complete and classified platelet proteome from genome-wide transcripts of human platelets and megakaryocytes covering platelet functions

First clinical and myopathological description of a myofibrillar myopathy with congenital onset and homozygous mutation in FLNC

Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery

Phenotypical and Myopathological Consequences of Compound Heterozygous Missense and Nonsense Variants in SLC18A3

Proteomics: A Tool to Study Platelet Function

Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome

Targeted Approach to Distinguish and Determine Absolute Levels of GDF8 and GDF11 in Mouse Serum

Characterizing mitochondrial signaling networks by quantitative proteomics

Impaired iloprost-induced platelet inhibition and phosphoproteome changes in patients with confirmed pseudohypoparathyroidism type Ia, linked to genetic mutations in GNAS

Improving identification of in-organello protein-protein interactions using an affinity-enrichable, isotopically coded, and mass spectrometry-cleavable chemical crosslinker

Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome

Phosphoproteomic analysis of STRIPAK mutants identifies a conserved serine phosphorylation site in PAK kinase CLA4 to be important in fungal sexual development and polarized growth

The STRIPAK signaling complex regulates dephosphorylation of GUL1, an RNA-binding protein that shuttles on endosomes

Molecular biological elucidation of late tropane alkaloid biosynthesis

Molecular phenotyping of laboratory mouse strains using 500 multiple reaction monitoring mass spectrometry plasma assays

Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures

Disentangling thermal stress responses in a reef-calcifier and its photosymbionts by shotgun proteomics

Intersection of Proteomics and Genomics to “Solve the Unsolved” in Rare Disorders such as Neurodegenerative and Neuromuscular Diseases

Dieter Klockow (1934 – 2018)

Charakterisierung der Wechselwirkung post-translationaler Modifikationen mittels Massenspektrometrie-basierter Proteomforschung

Tracking Effects of SIL1 Increase: Taking a Closer Look Beyond the Consequences of Elevated Expression Level

DISMS2: A flexible algorithm for direct proteome- wide distance calculation of LC-MS/MS runs

Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous delG frameshift mutations in ITGA2B

Understanding platelets : Lessons from proteomics, genomics and promises from network analysis

PeptideTracker: A knowledge base for collecting and storing information on protein concentrations in biological tissues

Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic Archaea