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Axel Imhof

Hochschullehrer

Name	Axel Imhof
Time	1992- (Wirkungsdaten)
Place	Deutschland
Gender	männlich
Academic degree	Prof. Dr.
Profession	Hochschullehrer
Related	Ludwig-Maximilians-Universität München. Medizinische Fakultät Chromatin (Thema) Proteomanalyse (Thema)
Record type	Person
GND-Identifier	1276051425
Record ID	1276051425
Involved in show all Nuclear Hsp104 safeguards the dormant translation machinery during quiescence The fruit fly acetyltransferase chameau promotes starvation resilience at the expense of longevity PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity Comparison of clean catch and bag urine using LC–MS/MS proteomics in infants RNA polymerase II CTD is dispensable for transcription and required for termination in human cells SPRTN patient variants cause global-genome DNA-protein crosslink repair defects Improving SWATH‐MS analysis by deep‐learning Data analysis for genomics, transcriptomics and proteomics Screening for eukaryotic motifs in Legionella pneumophila reveals Smh1 as bacterial deacetylase of host histones Synthesis and Structure Elucidation of Glutamyl-Queuosine A multi-adenylate cyclase regulator at the flagellar tip controls African trypanosome transmission Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity Computational methods for exploratory analysis of proteomics data Die Bestimmung der Histon H4-Acetylierungsmuster in PBMCs im Alterungsprozess des Menschen mittels Massenspektrometrie ImShot: An Open-Source Software for Probabilistic Identification of Proteins In Situ and Visualization of Proteomics Data Probing protein ubiquitination in live cells The measurement of S-adenosyl methionine in situ Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities The potential of epigenetically-active small molecules in regulating metabolism-paving novel avenues for alternative treatment strategies Trnp1 organizes diverse nuclear membrane‐less compartments in neural stem cells Front Cover: New Approaches for Absolute Quantification of Stable‐Isotope‐Labeled Peptide Standards for Targeted Proteomics Based on a UV Active Tag New Approaches for Absolute Quantification of Stable‐Isotope‐Labeled Peptide Standards for Targeted Proteomics Based on a UV Active Tag Chromosome organization by a conserved condensin-ParB system in the actinobacterium Corynebacterium glutamicum Harmonization of quality metrics and power calculation in multi-omic studies Intricate structure of the interphase chromocenter revealed by proximity-based biotinylation Spt6 is a maintenance factor for centromeric CENP-A KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability Building ProteomeTools based on a complete synthetic human proteome The Impact of One Carbon Metabolism on Histone Methylation PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex Epigenetics and Metabolism in Health and Disease Functional characterization of HMGN5 in chromatin architecture and gene expression The ribosome receptors Mrx15 and Mba1 jointly organize cotranslational insertion and protein biogenesis in mitochondria ATM induces MacroD2 nuclear export upon DNA damage Proteomic analysis of assembled chromatin with SWATH-MS The Drosophila speciation factor HMR localizes to genomic insulator sites The Drosophila speciation factor HMR localizes to genomic insulator sites Inside front cover: In situ detection of histone variants and modifications in mouse brain using imaging mass spectrometry In situ detection of histone variants and modifications in mouse brain using imaging mass spectrometry A Focus on Chromatin Proteomics From HDAC i to KDAC i: we need to revisit non‐epigenetic pathways affected by inhibiting lysine deacetylases in therapy Life span extension by targeting a link between metabolism and histone acetylation in Drosophila Characterization of histone lysine demethylation DOT1A-dependent H3K76 methylation is required for replication regulation in Trypanosoma brucei Global and specific responses of the histone acetylene to systematic perturbation Methylation of histone H3 lysine 9 occurs during translation Bioinformatic analysis of proteomics data Identification of novel Drosophila centromere‐associated proteins Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate Differentielle Kontrolle von Histon-Methylierung und Demethylierung bei der Etablierung des heterochromatischen Gensilencings in Drosophila melanogaster H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. The RNA helicase Rm62 cooperates with SU(VAR)3-9 to re-silence active transcription in Drosophila melanogaster. Phosphorylation of SU(VAR)3-9 by the chromosomal kinase JIL-1 The HP1α–CAF1–SetDB1‐containing complex provides H3K9me1 for Suv39‐mediated K9me3 in pericentric heterochromatin Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc

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Axel Imhof

Nuclear Hsp104 safeguards the dormant translation machinery during quiescence

The fruit fly acetyltransferase chameau promotes starvation resilience at the expense of longevity

PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma

Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity

Comparison of clean catch and bag urine using LC–MS/MS proteomics in infants

RNA polymerase II CTD is dispensable for transcription and required for termination in human cells

SPRTN patient variants cause global-genome DNA-protein crosslink repair defects

Improving SWATH‐MS analysis by deep‐learning

Data analysis for genomics, transcriptomics and proteomics

Screening for eukaryotic motifs in Legionella pneumophila reveals Smh1 as bacterial deacetylase of host histones

Synthesis and Structure Elucidation of Glutamyl-Queuosine

A multi-adenylate cyclase regulator at the flagellar tip controls African trypanosome transmission

Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity

Computational methods for exploratory analysis of proteomics data

Die Bestimmung der Histon H4-Acetylierungsmuster in PBMCs im Alterungsprozess des Menschen mittels Massenspektrometrie

ImShot: An Open-Source Software for Probabilistic Identification of Proteins In Situ and Visualization of Proteomics Data

Probing protein ubiquitination in live cells

The measurement of S-adenosyl methionine in situ

Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

The potential of epigenetically-active small molecules in regulating metabolism-paving novel avenues for alternative treatment strategies

Trnp1 organizes diverse nuclear membrane‐less compartments in neural stem cells

Front Cover: New Approaches for Absolute Quantification of Stable‐Isotope‐Labeled Peptide Standards for Targeted Proteomics Based on a UV Active Tag

New Approaches for Absolute Quantification of Stable‐Isotope‐Labeled Peptide Standards for Targeted Proteomics Based on a UV Active Tag

Chromosome organization by a conserved condensin-ParB system in the actinobacterium Corynebacterium glutamicum

Harmonization of quality metrics and power calculation in multi-omic studies

Intricate structure of the interphase chromocenter revealed by proximity-based biotinylation

Spt6 is a maintenance factor for centromeric CENP-A

KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells

Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma

Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability

Building ProteomeTools based on a complete synthetic human proteome

The Impact of One Carbon Metabolism on Histone Methylation

PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex

Epigenetics and Metabolism in Health and Disease

Functional characterization of HMGN5 in chromatin architecture and gene expression

The ribosome receptors Mrx15 and Mba1 jointly organize cotranslational insertion and protein biogenesis in mitochondria

ATM induces MacroD2 nuclear export upon DNA damage

Proteomic analysis of assembled chromatin with SWATH-MS

The Drosophila speciation factor HMR localizes to genomic insulator sites

The Drosophila speciation factor HMR localizes to genomic insulator sites

Inside front cover: In situ detection of histone variants and modifications in mouse brain using imaging mass spectrometry

In situ detection of histone variants and modifications in mouse brain using imaging mass spectrometry

A Focus on Chromatin Proteomics

From HDAC i to KDAC i: we need to revisit non‐epigenetic pathways affected by inhibiting lysine deacetylases in therapy

Life span extension by targeting a link between metabolism and histone acetylation in Drosophila

Characterization of histone lysine demethylation

DOT1A-dependent H3K76 methylation is required for replication regulation in Trypanosoma brucei

Global and specific responses of the histone acetylene to systematic perturbation

Methylation of histone H3 lysine 9 occurs during translation

Bioinformatic analysis of proteomics data

Identification of novel Drosophila centromere‐associated proteins

Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate

Differentielle Kontrolle von Histon-Methylierung und Demethylierung bei der Etablierung des heterochromatischen Gensilencings in Drosophila melanogaster

H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation

Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome.

The RNA helicase Rm62 cooperates with SU(VAR)3-9 to re-silence active transcription in Drosophila melanogaster.

Phosphorylation of SU(VAR)3-9 by the chromosomal kinase JIL-1

The HP1α–CAF1–SetDB1‐containing complex provides H3K9me1 for Suv39‐mediated K9me3 in pericentric heterochromatin

Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc