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Axel Schambach (1974-)

Name	Axel Schambach
Time	1974- (Date of birth and death)
Place	Hamburg (Geburtsort) Hannover (Wirkungsort)
Academic degree	Prof. Dr. med.; PhD
Related	Medizinische Hochschule Hannover Medizinische Hochschule Hannover. Institut Experimentelle Hämatologie (Leiter)
Further information	Diss. (Ph.D) und Habil. Fach Molekulare Medizin an der Medizinischen Hochschule Hannover
Record type	Person
GND-Identifier	128643250
Record ID	128643250
Involved in show all Blood-generating heart-forming organoids recapitulate co-development of the human haematopoietic system and the embryonic heart The caspase-inhibitor Emricasan efficiently counteracts cisplatin- and neomycin-induced cytotoxicity in cochlear cells A spatiotemporal atlas of mouse liver homeostasis and regeneration CRISPR-Cas12a for highly efficient and marker-free targeted integration in human pluripotent stem cells Using advanced CRISPR-Cas9 functional genetics to model and probe T cell acute lymphoblastic leukemia (T-ALL) CAR-NK cell therapy targeting HER1 and CD44v6 in combination with other therapeutic strategies against HNSCC Developing and improving genome editing as a therapeutic tool for hereditary hemochromatosis Gene therapy : decreasing MHC expression of cells, organs and beyond Investigation of the cellular Fabry disease phenotype using human iPSC-derived cardiomyocytes Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis Back to pluripotency: fully chemically induced reboot of human somatic cells Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis Delineating the relevance of phenotypic identity in normal and malignant hematopoiesis by fluorescent genetic barcoding Molecular principles and determinants of Hepatitis C Virus cell culture adaptation A Multiplex CRISPR‐Screen Identifies PLA2G4A as Prognostic Marker and Druggable Target for HOXA9 and MEIS1 Dependent AML Development of genetic safety switches and their validation Functional characterisation of the mitotic role of RAD50 Patient-specific induced pluripotent stem cell-derived endothelial cells as in vitro disease model for pulmonary arterial hypertension Pulmonary transplantation of alpha-1 antitrypsin (AAT)-transgenic macrophages provides a source of functional human AAT in vivo Cooperating, congenital neutropenia–associated Csf3r and Runx1 mutations activate pro-inflammatory signaling and inhibit myeloid differentiation of mouse HSPCs Lentiviral gene therapy and vitamin B3 treatment enable granulocytic differentiation of G6PC3-deficient induced pluripotent stem cells Circular RNA insulin receptor protects against doxorubicin-mediated cardiotoxicity High cytotoxic efficiency of lentivirally and alpharetrovirally engineered CD19-specific chimeric antigen receptor natural killer cells against acute lymphoblastic leukemia Lentiviral genetic barcoding for functional characterization of human umbilical cord derived mesenchymal stromal cells Small scale variants in the nuclear and mitochondrial genome of human induced pluripotent stem cells : analysis of potential de novo mutagenesis and selection dynamics during reprogramming, culture expansion and differentiation Study of the effects of miRNA-mediated BCL11A knockdown and gamma-globin induction in sickle cell anemia : evaluation of a lentiviral system with tetracycline-inducible, dosage-dependent transgene expression Targeted integration of inducible Caspase-9 in human iPSCs allows efficient in vitro clearance of iPSCs and iPSC-macrophages Expression of a chimeric antigen receptor in lymphoid progenitors suppresses T cell but favors NK cell-like development Generation of therapeutically effective stem cell transplants by targeted genome modification Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections A patient-specific induced pluripotent stem cell model for West syndrome caused by ST3GAL3 deficiency An in vitro liver zonation system based on controlled modulation of Wnt-signalling in hepatic cells T-cell gene therapy for perforin deficiency corrects cytotoxicity defects and prevents hemophagocytic lymphohistiocytosis manifestations Correction to: Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells Glycomic characterization of induced pluripotent stem cells derived from a patient suffering from phosphomannomutase 2 congenital disorder of glycosylation (PMM2-CDG) Non-coding RNAs as ‘theranostics’ in heart, lung and circulation A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells From bench to bedside : preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease Gene therapy on the move Gene therapy on the move Gentherapie von somatischen und reprogrammierten Zellen Comparison of the activity and pluripotency maintaining potential of human leukemia inhibitory factor (LIF) produced in E.coliand CHO cells miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2 Improved retroviral vector design for gene therapy in the hematopoietic system Optimierung der Transgenexpression retroviraler Gentherapie-Vektoren durch Einsatz posttranskriptionell regulatorischer Elemente Optimierung der Transgenexpression retroviraler Gentherapie-Vektoren durch Einsatz posttranskriptionell regulatorischer Elemente

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Katalog der Deutschen Nationalbibliothek

Axel Schambach (1974-)

Blood-generating heart-forming organoids recapitulate co-development of the human haematopoietic system and the embryonic heart

The caspase-inhibitor Emricasan efficiently counteracts cisplatin- and neomycin-induced cytotoxicity in cochlear cells

A spatiotemporal atlas of mouse liver homeostasis and regeneration

CRISPR-Cas12a for highly efficient and marker-free targeted integration in human pluripotent stem cells

Using advanced CRISPR-Cas9 functional genetics to model and probe T cell acute lymphoblastic leukemia (T-ALL)

CAR-NK cell therapy targeting HER1 and CD44v6 in combination with other therapeutic strategies against HNSCC

Developing and improving genome editing as a therapeutic tool for hereditary hemochromatosis

Gene therapy : decreasing MHC expression of cells, organs and beyond

Investigation of the cellular Fabry disease phenotype using human iPSC-derived cardiomyocytes

Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis

Back to pluripotency: fully chemically induced reboot of human somatic cells

Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis

Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis

Delineating the relevance of phenotypic identity in normal and malignant hematopoiesis by fluorescent genetic barcoding

Molecular principles and determinants of Hepatitis C Virus cell culture adaptation

A Multiplex CRISPR‐Screen Identifies PLA2G4A as Prognostic Marker and Druggable Target for HOXA9 and MEIS1 Dependent AML

Development of genetic safety switches and their validation

Functional characterisation of the mitotic role of RAD50

Patient-specific induced pluripotent stem cell-derived endothelial cells as in vitro disease model for pulmonary arterial hypertension

Pulmonary transplantation of alpha-1 antitrypsin (AAT)-transgenic macrophages provides a source of functional human AAT in vivo

Cooperating, congenital neutropenia–associated Csf3r and Runx1 mutations activate pro-inflammatory signaling and inhibit myeloid differentiation of mouse HSPCs

Lentiviral gene therapy and vitamin B3 treatment enable granulocytic differentiation of G6PC3-deficient induced pluripotent stem cells

Circular RNA insulin receptor protects against doxorubicin-mediated cardiotoxicity

High cytotoxic efficiency of lentivirally and alpharetrovirally engineered CD19-specific chimeric antigen receptor natural killer cells against acute lymphoblastic leukemia

Lentiviral genetic barcoding for functional characterization of human umbilical cord derived mesenchymal stromal cells

Small scale variants in the nuclear and mitochondrial genome of human induced pluripotent stem cells : analysis of potential de novo mutagenesis and selection dynamics during reprogramming, culture expansion and differentiation

Study of the effects of miRNA-mediated BCL11A knockdown and gamma-globin induction in sickle cell anemia : evaluation of a lentiviral system with tetracycline-inducible, dosage-dependent transgene expression

Targeted integration of inducible Caspase-9 in human iPSCs allows efficient in vitro clearance of iPSCs and iPSC-macrophages

Expression of a chimeric antigen receptor in lymphoid progenitors suppresses T cell but favors NK cell-like development

Generation of therapeutically effective stem cell transplants by targeted genome modification

Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections

A patient-specific induced pluripotent stem cell model for West syndrome caused by ST3GAL3 deficiency

An in vitro liver zonation system based on controlled modulation of Wnt-signalling in hepatic cells

T-cell gene therapy for perforin deficiency corrects cytotoxicity defects and prevents hemophagocytic lymphohistiocytosis manifestations

Correction to: Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells

Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells

Glycomic characterization of induced pluripotent stem cells derived from a patient suffering from phosphomannomutase 2 congenital disorder of glycosylation (PMM2-CDG)

Non-coding RNAs as ‘theranostics’ in heart, lung and circulation

A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells

From bench to bedside : preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease

Gene therapy on the move

Gene therapy on the move

Gentherapie von somatischen und reprogrammierten Zellen

Comparison of the activity and pluripotency maintaining potential of human leukemia inhibitory factor (LIF) produced in E.coliand CHO cells

miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2

Improved retroviral vector design for gene therapy in the hematopoietic system

Optimierung der Transgenexpression retroviraler Gentherapie-Vektoren durch Einsatz posttranskriptionell regulatorischer Elemente

Optimierung der Transgenexpression retroviraler Gentherapie-Vektoren durch Einsatz posttranskriptionell regulatorischer Elemente