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Maja Köhn (1975-)

Chemikerin

Name	Maja Köhn
Time	1975- (Date of birth and death)
Place	Kiel (Geburtsort) Deutschland
Gender	weiblich
Academic degree	Prof. Dr.
Profession	Chemikerin (characteristic profession) Hochschullehrerin
Variant	Maja Koehn
Related	Max-Planck-Institut für Molekulare Physiologie (Wissenschaftliche Mitarbeiterin und Doktorandin) (2002-2005) Universität Dortmund. Fachbereich Chemie (Wissenschaftliche Mitarbeiterin und Doktorandin (AG Waldmann)) (2002-2005) European Molecular Biology Laboratory (Forschungsgruppenleiterin) (2007-2016) Albert-Ludwigs-Universität Freiburg. Institut für Biologie III (Professorin) (2016-)
Further information	Studium der Chemie an der Universität zu Kiel. Promotion an der TU Dortmund, 2005.
Source	Homepage: http://www.bioss.uni-freiburg.de/de/prof-dr-maja-koehn/ (07.11.2017)
Record type	Person
GND-Identifier	130328367
Record ID	130328367
Involved in show all Synthetic trap-peptides identify a TOM complex phosphatase - PP2A dephosphorylates Tom6 Development of a Peptide Inhibitor Targeting the C‐SH2 Domain of the SHP2 Phosphatase Development of a peptide inhibitor targeting the C‐SH2 domain of the SHP2 phosphatase Discovery of inhibitors of the cancer-promoting phosphatase PRL-3 and their evaluation in intestinal organoids Identification of phosphatases that dephosphorylate the co-chaperone BAG3 Protein phosphatase-1 regulates the binding of filamin C to FILIP1 in cultured skeletal muscle cells under mechanical stress Photo‐Claisen Rearrangement in a Coumarin‐Caged Peptide Leads to a Surprising Enzyme Hyperactivation PenTag, a Versatile Platform for Synthesizing Protein‐Polymer Biohybrid Materials (Adv. Funct. Mater. 35/2024) A modular approach for the synthesis of diverse heterobifunctional cyanine dyes A strategy to disentangle direct and indirect effects on (de)phosphorylation by chemical modulators of the phosphatase PP1 in complex cellular contexts Characterisation of cells and organoids derived from a phosphatase of regenerating liver-3 (PRL-3)-overexpressing mouse model and their application to develop PRL-3 inhibitors New inositol pyrophosphate prometabolites: specific organelle targeting, tissue penetration, and stable isotope labelling PenTag, a Versatile Platform for Synthesizing Protein-Polymer Biohybrid Materials PenTag, a Versatile Platform for Synthesizing Protein‐Polymer Biohybrid Materials PenTag, a Versatile Platform for Synthesizing Protein‐Polymer Biohybrid Materials Photo‐claisen rearrangement in a coumarin‐caged peptide leads to a surprising enzyme hyperactivation Protein phosphatase-1 regulates the binding of filamin C to FILIP1 in cultured skeletal muscle cells under mechanical stress PenTag, a Versatile Platform for Synthesizing Protein‐Polymer Biohybrid Materials Elucidating novel mechanisms of stress-induced transcriptional attenuation (SITA) Inhibition of SH2-domain-mediated protein-protein interactions of the phosphatase SHP2 and the effect on its activity Membrane targeting with palmitoylated lysine added to PP1‐disrupting peptide induces PP1‐independent signaling Modification of dietary substrates impacts glucose homeostasis in very long-chain Acyl-CoA dehydrogenase deficient (VLCAD-/-) mice Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A Unraveling the roles of ammonium transporters and receptors through structural and functional characterization Biosensor‐Enabled Multiplexed On‐Site Therapeutic Drug Monitoring of Antibiotics Biosensor‐Enabled Multiplexed On‐Site Therapeutic Drug Monitoring of Antibiotics (Adv. Mater. 2/2022) Biosensor‐enabled multiplexed on‐site therapeutic drug monitoring of antibiotics Creation of a light-induced intein splicing tool for protein reconstitution Exploring uncharted territory : : toward metabolite network maps Short peptide pharmacophores developed from protein phosphatase-1 disrupting peptides (PDPs) Maintaining proteostasis under mechanical stress The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition Structural basis of Naa20 activity towards a canonical NatB substrate Cross-TCR antagonism revealed by optogenetically tuning the half-life of the TCR ligand binding DTL-DephosSite: deep transfer learning based approach to predict dephosphorylation sites Evolutionary crossroads of cell signaling: PP1 and PP2A substrate sites in intrinsically disordered regions finDr: A web server for in silico D-peptide ligand identification Heterobivalente Radiopharmaka um die intratumorale Heterogenität zu adressieren Maintaining proteostasis under mechanical stress Protein tyrosine phosphatases in multiple myeloma Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling Structural basis of Naa20 activity towards a canonical NatB substrate The Leishmania donovani LDBPK_220120.1 gene encodes for an atypical dual specificity lipid-like phosphatase expressed in promastigotes and amastigotes; substrate specificity, intracellular localizations, and putative role(s) The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition Towards dissecting the mechanism of protein phosphatase‐1 inhibition by its c‐terminal phosphorylation Author Correction: Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function Towards Dissecting the Mechanism of Protein Phosphatase‐1 Inhibition by Its C ‐Terminal Phosphorylation Development of a photoactivatable protein phosphatase-1-disrupting peptide Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A Molecular mechanism of SHP2 activation by PD-1 stimulation Non-canonical binding of the LCK SH3 domain to CD3[epsilon] redefines initiation of TCR signaling and enhances CAR function = Non-canonical binding of LCK to the TCR The receptor PTPRU is a redox sensitive pseudophosphatase Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling Interrogating PP1 Activity in the MAPK Pathway with Optimized PP1‐Disrupting Peptides Cover Feature: Interrogating PP1 Activity in the MAPK Pathway with Optimized PP1‐Disrupting Peptides (ChemBioChem 1/2019) Interrogating PP1 activity in the MAPK pathway with optimized PP1‐disrupting peptides Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein The human DEPhOsphorylation Database DEPOD: 2019 update Effects of stably incorporated iron on protein phosphatase‐1 structure and activity

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Katalog der Deutschen Nationalbibliothek

Maja Köhn (1975-)

Synthetic trap-peptides identify a TOM complex phosphatase - PP2A dephosphorylates Tom6

Development of a Peptide Inhibitor Targeting the C‐SH2 Domain of the SHP2 Phosphatase

Development of a peptide inhibitor targeting the C‐SH2 domain of the SHP2 phosphatase

Discovery of inhibitors of the cancer-promoting phosphatase PRL-3 and their evaluation in intestinal organoids

Identification of phosphatases that dephosphorylate the co-chaperone BAG3

Protein phosphatase-1 regulates the binding of filamin C to FILIP1 in cultured skeletal muscle cells under mechanical stress

Photo‐Claisen Rearrangement in a Coumarin‐Caged Peptide Leads to a Surprising Enzyme Hyperactivation

PenTag, a Versatile Platform for Synthesizing Protein‐Polymer Biohybrid Materials (Adv. Funct. Mater. 35/2024)

A modular approach for the synthesis of diverse heterobifunctional cyanine dyes

A strategy to disentangle direct and indirect effects on (de)phosphorylation by chemical modulators of the phosphatase PP1 in complex cellular contexts

Characterisation of cells and organoids derived from a phosphatase of regenerating liver-3 (PRL-3)-overexpressing mouse model and their application to develop PRL-3 inhibitors

New inositol pyrophosphate prometabolites: specific organelle targeting, tissue penetration, and stable isotope labelling

PenTag, a Versatile Platform for Synthesizing Protein-Polymer Biohybrid Materials

PenTag, a Versatile Platform for Synthesizing Protein‐Polymer Biohybrid Materials

PenTag, a Versatile Platform for Synthesizing Protein‐Polymer Biohybrid Materials

Photo‐claisen rearrangement in a coumarin‐caged peptide leads to a surprising enzyme hyperactivation

Protein phosphatase-1 regulates the binding of filamin C to FILIP1 in cultured skeletal muscle cells under mechanical stress

PenTag, a Versatile Platform for Synthesizing Protein‐Polymer Biohybrid Materials

Elucidating novel mechanisms of stress-induced transcriptional attenuation (SITA)

Inhibition of SH2-domain-mediated protein-protein interactions of the phosphatase SHP2 and the effect on its activity

Membrane targeting with palmitoylated lysine added to PP1‐disrupting peptide induces PP1‐independent signaling

Modification of dietary substrates impacts glucose homeostasis in very long-chain Acyl-CoA dehydrogenase deficient (VLCAD-/-) mice

Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A

Unraveling the roles of ammonium transporters and receptors through structural and functional characterization

Biosensor‐Enabled Multiplexed On‐Site Therapeutic Drug Monitoring of Antibiotics

Biosensor‐Enabled Multiplexed On‐Site Therapeutic Drug Monitoring of Antibiotics (Adv. Mater. 2/2022)

Biosensor‐enabled multiplexed on‐site therapeutic drug monitoring of antibiotics

Creation of a light-induced intein splicing tool for protein reconstitution

Exploring uncharted territory : : toward metabolite network maps

Short peptide pharmacophores developed from protein phosphatase-1 disrupting peptides (PDPs)

Maintaining proteostasis under mechanical stress

The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition

Structural basis of Naa20 activity towards a canonical NatB substrate

Cross-TCR antagonism revealed by optogenetically tuning the half-life of the TCR ligand binding

DTL-DephosSite: deep transfer learning based approach to predict dephosphorylation sites

Evolutionary crossroads of cell signaling: PP1 and PP2A substrate sites in intrinsically disordered regions

finDr: A web server for in silico D-peptide ligand identification

Heterobivalente Radiopharmaka um die intratumorale Heterogenität zu adressieren

Maintaining proteostasis under mechanical stress

Protein tyrosine phosphatases in multiple myeloma

Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling

Structural basis of Naa20 activity towards a canonical NatB substrate

The Leishmania donovani LDBPK_220120.1 gene encodes for an atypical dual specificity lipid-like phosphatase expressed in promastigotes and amastigotes; substrate specificity, intracellular localizations, and putative role(s)

The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition

Towards dissecting the mechanism of protein phosphatase‐1 inhibition by its c‐terminal phosphorylation

Author Correction: Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function

Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function

Towards Dissecting the Mechanism of Protein Phosphatase‐1 Inhibition by Its C ‐Terminal Phosphorylation

Development of a photoactivatable protein phosphatase-1-disrupting peptide

Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A

Molecular mechanism of SHP2 activation by PD-1 stimulation

Non-canonical binding of the LCK SH3 domain to CD3[epsilon] redefines initiation of TCR signaling and enhances CAR function = Non-canonical binding of LCK to the TCR

The receptor PTPRU is a redox sensitive pseudophosphatase

Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling

Interrogating PP1 Activity in the MAPK Pathway with Optimized PP1‐Disrupting Peptides

Cover Feature: Interrogating PP1 Activity in the MAPK Pathway with Optimized PP1‐Disrupting Peptides (ChemBioChem 1/2019)

Interrogating PP1 activity in the MAPK pathway with optimized PP1‐disrupting peptides

Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein

The human DEPhOsphorylation Database DEPOD: 2019 update

Effects of stably incorporated iron on protein phosphatase‐1 structure and activity