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Mark Helm (1969-)

Chemiker

Name	Mark Helm
Time	1969- (Date of birth and death)
Place	Deutschland
Academic degree	Dr. (CNRS Straßburg) (1999) Dipl.
Profession	Chemiker (characteristic profession)
Related	Johannes Gutenberg-Universität Mainz (2009-) Universität Heidelberg. Institut für Pharmazie und Molekulare Biotechnologie (2002-2009)
Further information	Prof. im Institut für Pharmazie und Biochemie, Universität Mainz
Record type	Person
GND-Identifier	132228076
Record ID	132228076
Involved in show all Evolutionary conservation of ubiquitin-like protein urmylation as revealed by URM1 gene shuffle from archaea to yeast Mapping of HOCl-oxidized RNA identifies abasic sites as major damage and oxidation product of oxo8G Queuosine is incorporated into precursor tRNA before splicing The RMaP challenge of predicting RNA modifications by nanopore sequencing A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors The P(III)‐amidite based synthesis of stable isotope labeled mRNA‐cap‐structures enables their sensitive quantitation from brain tissue The P(III)‐amidite based synthesis of stable isotopelLabeled mRNA‐cap‐structures enables their sensitive quantitation from brain tissue Dual Centrifugation‐Based Screening for pH‐Responsive Liposomes The P (III)‐Amidite Based Synthesis of Stable Isotope Labeled mRNA‐Cap‐Structures Enables their Sensitive Quantitation from Brain Tissue The P (III)‐Amidite Based Synthesis of Stable Isotope Labeled mRNA‐Cap‐Structures Enables their Sensitive Quantitation from Brain Tissue Selective RNA pseudouridinylation in situ by circular gRNAs in designer organelles Nascent mRNA damage: depot and disposal Esterification of Cyclic N 6 ‐Threonylcarbamoyladenosine During RNA Sample Preparation N1-methylation of adenosine (m1A) in ND5 mRNA leads to complex I dysfunction in Alzheimer’s disease Front Cover: Esterification of Cyclic N 6 ‐Threonylcarbamoyladenosine During RNA Sample Preparation (ChemMedChem 13/2024) Optimisation of next generation sequencing methodologies for RNA modifications detection RNA modifications in physiology and disease: towards clinical applications Queuosine‐tRNA promotes sex‐dependent learning and memory formation by maintaining codon‐biased translation elongation speed METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer Ein neues bakterielles, von Adenosin abgeleitetes Nukleosid als Beispiel für RNA‐Modifikationsschäden A New Bacterial Adenosine‐Derived Nucleoside as an Example of RNA Modification Damage RNA modifications stabilize the tertiary structure of tRNAfMet by locally increasing conformational dynamics RNA nucleotide methylation: 2021 update Biallelic variants in YRDC cause a developmental disorder with progeroid features Binding and/or hydrolysis of purine-based nucleotides is not required for IM30 ring formation General principles for the detection of modified nucleotides in RNA by specific reagents In-depth immune-oncology studies of the tumor microenvironment in a humanized melanoma mouse model Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression Translational adaptation to heat stress is mediated by RNA 5‐methylcytosine in Caenorhabditis elegans A tRNA half modulates translation as stress response in Trypanosoma brucei Absolute Quantifizierung nicht‐kodierender RNA‐Spezies mittels Mikroskala‐Thermophorese Absolute Quantification of Noncoding RNA by Microscale Thermophoresis Absolute quantification of noncoding RNA by microscale thermophoresis Absolute Quantifizierung nicht‐kodierender RNA‐Spezies mittels Mikroskala‐Thermophorese Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy AlkAniline‐Seq: Profiling of m 7 G and m 3 C RNA Modifications at Single Nucleotide Resolution Die stark wachsende chemische Vielfalt der RNA‐Modifikationen enthält eine Thioacetalstruktur Innentitelbild: Die stark wachsende chemische Vielfalt der RNA‐Modifikationen enthält eine Thioacetalstruktur (Angew. Chem. 26/2018) Entwicklung einer DNA‐Polymerase für die direkte m 6 A‐Sequenzierung AlkAniline‐Seq: Profiling of m 7 G and m 3 C RNA Modifications at Single Nucleotide Resolution A Vastly Increased Chemical Variety of RNA Modifications Containing a Thioacetal Structure Inside Cover: A Vastly Increased Chemical Variety of RNA Modifications Containing a Thioacetal Structure (Angew. Chem. Int. Ed. 26/2018) Engineering of a DNA Polymerase for Direct m 6 A Sequencing Engineering of a DNA Polymerase for Direct m<sup>6</sup>A Sequencing PeptoSomes for Vaccination: Combining Antigen and Adjuvant in Polypept (o) ide‐Based Polymersomes Modulation of Mitochondriotropic Properties of Cyanine Dyes by in Organello Copper‐Free Click Reaction Orthogonal Click Conjugation to the Liposomal Surface Reveals the Stability of the Lipid Anchorage as Crucial for Targeting Aberrant methylation of t RNA s links cellular stress to neuro‐developmental disorders The Guanidinium Group as a Key Part of Water‐Soluble Polymer Carriers for siRNA Complexation and Protection against Degradation Partial methylation at Am100 in 18S rRNA of baker's yeast reveals ribosome heterogeneity on the level of eukaryotic rRNA modification Instrumentelle Bioanalytik : Einführung für Biologen, Biochemiker, Biotechnologen und Pharmazeuten Instrumentelle Bioanalytik : Einführung für Biologen, Biochemiker, Biotechnologen und Pharmazeuten

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Katalog der Deutschen Nationalbibliothek

Mark Helm (1969-)

Evolutionary conservation of ubiquitin-like protein urmylation as revealed by URM1 gene shuffle from archaea to yeast

Mapping of HOCl-oxidized RNA identifies abasic sites as major damage and oxidation product of oxo8G

Queuosine is incorporated into precursor tRNA before splicing

The RMaP challenge of predicting RNA modifications by nanopore sequencing

A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors

The P(III)‐amidite based synthesis of stable isotope labeled mRNA‐cap‐structures enables their sensitive quantitation from brain tissue

The P(III)‐amidite based synthesis of stable isotopelLabeled mRNA‐cap‐structures enables their sensitive quantitation from brain tissue

Dual Centrifugation‐Based Screening for pH‐Responsive Liposomes

The P (III)‐Amidite Based Synthesis of Stable Isotope Labeled mRNA‐Cap‐Structures Enables their Sensitive Quantitation from Brain Tissue

The P (III)‐Amidite Based Synthesis of Stable Isotope Labeled mRNA‐Cap‐Structures Enables their Sensitive Quantitation from Brain Tissue

Selective RNA pseudouridinylation in situ by circular gRNAs in designer organelles

Nascent mRNA damage: depot and disposal

Esterification of Cyclic N 6 ‐Threonylcarbamoyladenosine During RNA Sample Preparation

N1-methylation of adenosine (m1A) in ND5 mRNA leads to complex I dysfunction in Alzheimer’s disease

Front Cover: Esterification of Cyclic N 6 ‐Threonylcarbamoyladenosine During RNA Sample Preparation (ChemMedChem 13/2024)

Optimisation of next generation sequencing methodologies for RNA modifications detection

RNA modifications in physiology and disease: towards clinical applications

Queuosine‐tRNA promotes sex‐dependent learning and memory formation by maintaining codon‐biased translation elongation speed

METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

Ein neues bakterielles, von Adenosin abgeleitetes Nukleosid als Beispiel für RNA‐Modifikationsschäden

A New Bacterial Adenosine‐Derived Nucleoside as an Example of RNA Modification Damage

RNA modifications stabilize the tertiary structure of tRNAfMet by locally increasing conformational dynamics

RNA nucleotide methylation: 2021 update

Biallelic variants in YRDC cause a developmental disorder with progeroid features

Binding and/or hydrolysis of purine-based nucleotides is not required for IM30 ring formation

General principles for the detection of modified nucleotides in RNA by specific reagents

In-depth immune-oncology studies of the tumor microenvironment in a humanized melanoma mouse model

Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression

Translational adaptation to heat stress is mediated by RNA 5‐methylcytosine in Caenorhabditis elegans

A tRNA half modulates translation as stress response in Trypanosoma brucei

Absolute Quantifizierung nicht‐kodierender RNA‐Spezies mittels Mikroskala‐Thermophorese

Absolute Quantification of Noncoding RNA by Microscale Thermophoresis

Absolute quantification of noncoding RNA by microscale thermophoresis

Absolute Quantifizierung nicht‐kodierender RNA‐Spezies mittels Mikroskala‐Thermophorese

Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy

AlkAniline‐Seq: Profiling of m 7 G and m 3 C RNA Modifications at Single Nucleotide Resolution

Die stark wachsende chemische Vielfalt der RNA‐Modifikationen enthält eine Thioacetalstruktur

Innentitelbild: Die stark wachsende chemische Vielfalt der RNA‐Modifikationen enthält eine Thioacetalstruktur (Angew. Chem. 26/2018)

Entwicklung einer DNA‐Polymerase für die direkte m 6 A‐Sequenzierung

AlkAniline‐Seq: Profiling of m 7 G and m 3 C RNA Modifications at Single Nucleotide Resolution

A Vastly Increased Chemical Variety of RNA Modifications Containing a Thioacetal Structure

Inside Cover: A Vastly Increased Chemical Variety of RNA Modifications Containing a Thioacetal Structure (Angew. Chem. Int. Ed. 26/2018)

Engineering of a DNA Polymerase for Direct m 6 A Sequencing

Engineering of a DNA Polymerase for Direct m<sup>6</sup>A Sequencing

PeptoSomes for Vaccination: Combining Antigen and Adjuvant in Polypept (o) ide‐Based Polymersomes

Modulation of Mitochondriotropic Properties of Cyanine Dyes by in Organello Copper‐Free Click Reaction

Orthogonal Click Conjugation to the Liposomal Surface Reveals the Stability of the Lipid Anchorage as Crucial for Targeting

Aberrant methylation of t RNA s links cellular stress to neuro‐developmental disorders

The Guanidinium Group as a Key Part of Water‐Soluble Polymer Carriers for siRNA Complexation and Protection against Degradation

Partial methylation at Am100 in 18S rRNA of baker's yeast reveals ribosome heterogeneity on the level of eukaryotic rRNA modification

Instrumentelle Bioanalytik : Einführung für Biologen, Biochemiker, Biotechnologen und Pharmazeuten

Instrumentelle Bioanalytik : Einführung für Biologen, Biochemiker, Biotechnologen und Pharmazeuten