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Jan G. Hengstler

Arzt

Name	Jan G. Hengstler
Time	1991- (Wirkungsdaten)
Place	Deutschland
Gender	männlich
Academic degree	Univ-Prof. Dr. med.
Profession	Arzt (characteristic profession)
Variant	Jan Georg Hengstler J. G. Hengstler
Related	Johannes Gutenberg-Universität Mainz. Institut für Toxikologie (Wissenschaftlicher Mitarbeiter) (1990-2002) Universität Leipzig (Professor für Molekulare Toxikologie) (2003-2007) Technische Universität Dortmund. Leibniz-Institut für Arbeitsforschung (Professor und Leiter des Forschungsbereichs Toxikologie / Systemtoxikologie) (2007-)
Further information	Diss. Mainz FB 04 Medizin 1991; Habil.-Schr. Mainz FB 04 Medizin (Inst. für Toxikologie) 1998; seit März 2007: Projektgruppe Molekulare Toxikologie am Leibniz Institut für Arbeitsphysiologie und Leiter der Projektgruppe "Gefahrstoffbelastungen und Suszeptibilität" am Institut für Arbeitsphysiologie an der Universität Dortmund
Source	Homepage: http://www.ifado.de/toxikologie/mitarbeiter/jan-hengstler/
Record type	Person
GND-Identifier	133617467
Record ID	133617467
Involved in show all Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food Adult ADHD: it is old and new at the same time – what is it? Basal MET phosphorylation is an indicator of hepatocyte dysregulation in liver disease Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food Controversy on health-based guidance values for bisphenol A : the need of criteria for studies that serve as a basis for risk assessment PFASs–restriction proposal commentary on ECHA’s Annex XV restriction report, proposal for a restriction, March 2023 Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS Transcriptome-based prediction of drugs, inhibiting cardiomyogenesis in human induced pluripotent stem cells PBTK modeling of the pyrrolizidine alkaloid retrorsine to predict liver toxicity in mouse and rat High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation Sublethal necroptosis signaling promotes inflammation and liver cancer Stellungnahme zu Acetaldehyd als Aromastoff: Aspekte der Risikobewertung Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds—a hypothesis New aspects in deriving health-based guidance values for bromate in swimming pool water High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation New aspects in deriving health-based guidance values for bromate in swimming pool water Stellungnahme zu Acetaldehyd als Aromastoff : Aspekte der Risikobewertung The EU chemicals strategy for sustainability : critical reflections on proposed regulatory changes for endocrine disruptors and mixture toxicity Integration of temporal single cell cellular stress response with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds Handling deviating control values in concentration-response curves Critical evaluation of human health risks due to hydraulic fracturing in natural gas and petroleum production Long-term simulation of lead concentrations in agricultural soils in relation to human adverse health effects Critical evaluation of human health risks due to hydraulic fracturing in natural gas and petroleum production Handling deviating control values in concentration-response curves Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation Long-term simulation of lead concentrations in agricultural soils in relation to human adverse health effects Unmasking selective path integration deficits in Alzheimer’s disease risk carriers Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project Hepatic osteodystrophy—molecular mechanisms proposed to favor its development IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis Towards grouping concepts based on new approach methodologies in chemical hazard assessment : the read-across approach of the EU-ToxRisk project Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes Essential components of methods papers Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes Adverse outcome pathways: opportunities, limitations and open questions Adverse outcome pathways : opportunities, limitations and open questions Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells Conflict of interest statements: current dilemma and a possible way forward A transcriptome-based classifier to identify developmental toxicants by stem cell testing : design, validation and optimization for histone deacetylase inhibitors Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells Conflict of interest Statements : current dilemma and a possible way forward From bisphenol A to bisphenol F and a ban of mustard due to chronic low-dose exposures? Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration Optimality in the zonation of ammonia detoxification in rodent liver From transient transcriptome responses to disturbed neurodevelopment : role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects Principles of Pharmacology and Toxicology : Also Govern Effects of Chemicals on the Endocrine System Toxicogenomics directory of chemically exposed human hepatocytes Acrylamide alters neurotransmitter induced calcium responses in murine ESC-derived and primary neurons Fatty Acid Elongation in Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma Lineage-specific regulation of epigenetic modifier genes in human liver and brain Microarrays for the scalable production of metabolically relevant tumour spheroids: a tool for modulating chemosensitivity traits Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery Test systems of developmental toxicity : state-of-the art and future perspectives Toxicogenomics directory of chemically exposed human hepatocytes Test systems of developmental toxicity: state-of-the art and future perspectives Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME Human embryonic stem cell-derived test systems for developmental neurotoxicity : a transcriptomics approach

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Katalog der Deutschen Nationalbibliothek

Jan G. Hengstler

Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food

Adult ADHD: it is old and new at the same time – what is it?

Basal MET phosphorylation is an indicator of hepatocyte dysregulation in liver disease

Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food

Controversy on health-based guidance values for bisphenol A : the need of criteria for studies that serve as a basis for risk assessment

PFASs–restriction proposal commentary on ECHA’s Annex XV restriction report, proposal for a restriction, March 2023

Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS

Transcriptome-based prediction of drugs, inhibiting cardiomyogenesis in human induced pluripotent stem cells

PBTK modeling of the pyrrolizidine alkaloid retrorsine to predict liver toxicity in mouse and rat

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation

Sublethal necroptosis signaling promotes inflammation and liver cancer

Stellungnahme zu Acetaldehyd als Aromastoff: Aspekte der Risikobewertung

Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds—a hypothesis

New aspects in deriving health-based guidance values for bromate in swimming pool water

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation

New aspects in deriving health-based guidance values for bromate in swimming pool water

Stellungnahme zu Acetaldehyd als Aromastoff : Aspekte der Risikobewertung

The EU chemicals strategy for sustainability : critical reflections on proposed regulatory changes for endocrine disruptors and mixture toxicity

Integration of temporal single cell cellular stress response with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury

The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds

Handling deviating control values in concentration-response curves

Critical evaluation of human health risks due to hydraulic fracturing in natural gas and petroleum production

Long-term simulation of lead concentrations in agricultural soils in relation to human adverse health effects

Critical evaluation of human health risks due to hydraulic fracturing in natural gas and petroleum production

Handling deviating control values in concentration-response curves

Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation

Long-term simulation of lead concentrations in agricultural soils in relation to human adverse health effects

Unmasking selective path integration deficits in Alzheimer’s disease risk carriers

Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project

Hepatic osteodystrophy—molecular mechanisms proposed to favor its development

IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis

Towards grouping concepts based on new approach methodologies in chemical hazard assessment : the read-across approach of the EU-ToxRisk project

Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes

Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes

Essential components of methods papers

Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes

Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes

Adverse outcome pathways: opportunities, limitations and open questions

Adverse outcome pathways : opportunities, limitations and open questions

Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells

Conflict of interest statements: current dilemma and a possible way forward

A transcriptome-based classifier to identify developmental toxicants by stem cell testing : design, validation and optimization for histone deacetylase inhibitors

Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells

Conflict of interest Statements : current dilemma and a possible way forward

From bisphenol A to bisphenol F and a ban of mustard due to chronic low-dose exposures?

Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration

Optimality in the zonation of ammonia detoxification in rodent liver

From transient transcriptome responses to disturbed neurodevelopment : role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects

Principles of Pharmacology and Toxicology : Also Govern Effects of Chemicals on the Endocrine System

Toxicogenomics directory of chemically exposed human hepatocytes

Acrylamide alters neurotransmitter induced calcium responses in murine ESC-derived and primary neurons

Fatty Acid Elongation in Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma

Lineage-specific regulation of epigenetic modifier genes in human liver and brain

Microarrays for the scalable production of metabolically relevant tumour spheroids: a tool for modulating chemosensitivity traits

Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery

Test systems of developmental toxicity : state-of-the art and future perspectives

Toxicogenomics directory of chemically exposed human hepatocytes

Test systems of developmental toxicity: state-of-the art and future perspectives

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Human embryonic stem cell-derived test systems for developmental neurotoxicity : a transcriptomics approach