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David Capper (1979-)

Arzt

Name	David Capper
Time	1979- (Date of birth and death)
Place	Stuttgart (Geburtsort) Heidelberg (Wirkungsort) Deutschland
Academic degree	Prof. Dr. med.
Profession	Arzt (characteristic profession)
Variant	D. Capper David Mark Capper
Related	Klinikum Heidelberg Universität Heidelberg. Pathologisches Institut (bis 2016) Charité - Universitätsmedizin Berlin (2017-)
Further information	Diss. Universität Tübingen, Medizinische Fakultät; eh. Oberarzt der Abteilung Neuropathologie des Pathologischen Instituts der Universität Heidelberg. Seit April 2017 Professor für molekulare Neuropathologie und Oberarzt im Institut für Neuropathologie an der Charité Berlin.
Record type	Person
GND-Identifier	133950751
Record ID	133950751
Involved in show all Rapid DNA methylation-based classification of pediatric brain tumors from ultrasonic aspirate specimens A prognostic neural epigenetic signature in high-grade glioma AHRR and SFRP2 in primary versus recurrent high-grade serous ovarian carcinoma and their prognostic implication Concurrent gliomas in patients with multiple sclerosis Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype: case series of a new entity Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival DNA methylation-based classification of sinonasal tumors Oligosarcomas, IDH-mutant are distinct and aggressive Genetic and epigenetic characterization of posterior pituitary tumors DNA methylation profiling identifies two distinct subgroups in breast cancers with low hormone receptor expression, mainly associated with HER2 amplification status GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors High-grade astrocytoma with piloid features (HGAP): the Charité experience with a new central nervous system tumor entity DNA methylation profiling identifies two distinct subgroups in breast cancers with low hormone receptor expression, mainly associated with HER2 amplification status Molecular characterisation of sporadic endolymphatic sac tumours and comparison to von Hippel–Lindau disease‐related tumours Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors The pediatric precision oncology INFORM registry: clinical outcome and benefit for patients with very high-evidence targets Phase 1b/2a study of galunisertib, a small molecule inhibitor of transforming growth factor-beta receptor I, in combination with standard temozolomide-based radiochemotherapy in patients with newly diagnosed malignant glioma Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course High density DNA methylation array is a reliable alternative for PCR-based analysis of the MGMT promoter methylation status in glioblastoma Actively personalized vaccination trial for newly diagnosed glioblastoma Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features DNA methylation-based reclassification of olfactory neuroblastoma Novel, improved grading system(s) for IDH-mutant astrocytic gliomas Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations Pericytes/vessel-associated mural cells (VAMCs) are the major source of key epithelial-mesenchymal transition (EMT) factors SLUG and TWIST in human glioma Histone 3.3 hotspot mutations in conventional osteosarcomas: a comprehensive clinical and molecular characterization of six H3F3A mutated cases H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo Biomarker and histopathology evaluation of patients with recurrent glioblastoma treated with galunisertib, lomustine, or the combination of galunisertib and lomustine Die Umwandlung differenzierter Glioblastoma Multiforme-Zellen in stammzellähnliche Zellen unter Temozolomid-Therapie in vitro Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux The whole-genome landscape of medulloblastoma subtypes Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas Announcing cIMPACT-NOW: the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone Evidence of H3 K27M mutations in posterior fossa ependymomas SHH desmoplastic/nodular medulloblastoma and Gorlin syndrome in the setting of Down syndrome: case report, molecular profiling, and review of the literature Prognostic value of the extent of resection in supratentorial WHO grade II astrocytomas stratified for IDH1 mutation status: a single-center volumetric analysis Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles Chemotherapy with BCNU in recurrent glioma: Analysis of clinical outcome and side effects in chemotherapy-naïve patients Methylation-based classification of benign and malignant peripheral nerve sheath tumors Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles New brain tumor entities emerge from molecular classification of CNS-PNETs Next-generation personalised medicine for high-risk paediatric cancer patients – the INFORM pilot study Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets

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David Capper (1979-)

Rapid DNA methylation-based classification of pediatric brain tumors from ultrasonic aspirate specimens

A prognostic neural epigenetic signature in high-grade glioma

AHRR and SFRP2 in primary versus recurrent high-grade serous ovarian carcinoma and their prognostic implication

Concurrent gliomas in patients with multiple sclerosis

Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype: case series of a new entity

Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability

Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability

Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma

Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival

DNA methylation-based classification of sinonasal tumors

Oligosarcomas, IDH-mutant are distinct and aggressive

Genetic and epigenetic characterization of posterior pituitary tumors

DNA methylation profiling identifies two distinct subgroups in breast cancers with low hormone receptor expression, mainly associated with HER2 amplification status

GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types

Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors

High-grade astrocytoma with piloid features (HGAP): the Charité experience with a new central nervous system tumor entity

DNA methylation profiling identifies two distinct subgroups in breast cancers with low hormone receptor expression, mainly associated with HER2 amplification status

Molecular characterisation of sporadic endolymphatic sac tumours and comparison to von Hippel–Lindau disease‐related tumours

Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas

Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors

The pediatric precision oncology INFORM registry: clinical outcome and benefit for patients with very high-evidence targets

Phase 1b/2a study of galunisertib, a small molecule inhibitor of transforming growth factor-beta receptor I, in combination with standard temozolomide-based radiochemotherapy in patients with newly diagnosed malignant glioma

Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course

High density DNA methylation array is a reliable alternative for PCR-based analysis of the MGMT promoter methylation status in glioblastoma

Actively personalized vaccination trial for newly diagnosed glioblastoma

Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma

Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience

Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features

DNA methylation-based reclassification of olfactory neuroblastoma

Novel, improved grading system(s) for IDH-mutant astrocytic gliomas

Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations

Pericytes/vessel-associated mural cells (VAMCs) are the major source of key epithelial-mesenchymal transition (EMT) factors SLUG and TWIST in human glioma

Histone 3.3 hotspot mutations in conventional osteosarcomas: a comprehensive clinical and molecular characterization of six H3F3A mutated cases

H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers

Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo

Biomarker and histopathology evaluation of patients with recurrent glioblastoma treated with galunisertib, lomustine, or the combination of galunisertib and lomustine

Die Umwandlung differenzierter Glioblastoma Multiforme-Zellen in stammzellähnliche Zellen unter Temozolomid-Therapie in vitro

Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux

The whole-genome landscape of medulloblastoma subtypes

Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas

Announcing cIMPACT-NOW: the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy

Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway

Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone

Evidence of H3 K27M mutations in posterior fossa ependymomas

SHH desmoplastic/nodular medulloblastoma and Gorlin syndrome in the setting of Down syndrome: case report, molecular profiling, and review of the literature

Prognostic value of the extent of resection in supratentorial WHO grade II astrocytomas stratified for IDH1 mutation status: a single-center volumetric analysis

Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis

Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles

Chemotherapy with BCNU in recurrent glioma: Analysis of clinical outcome and side effects in chemotherapy-naïve patients

Methylation-based classification of benign and malignant peripheral nerve sheath tumors

Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles

New brain tumor entities emerge from molecular classification of CNS-PNETs

Next-generation personalised medicine for high-risk paediatric cancer patients – the INFORM pilot study

Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets