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Klaus Thomas Überla

Facharzt

Name	Klaus Thomas Überla
Place	Abteilung für Molekulare und Medizinische Virologie, Ruhr-Universität Bochum (Wirkungsort) Sonstiges Ausland / Unbekanntes Land
Academic degree	Prof. Dr. med.
Profession	Facharzt (characteristic profession)
Variant	Klaus Überla Klaus T. Überla
Record type	Person
GND-Identifier	143295896
Record ID	143295896
Involved in show all Contribution of Fc-Effector Mechanisms to the Immunogenicity of Fc-Fusion Proteins and to the Efficacy of Passive Immunization Strategies Against HIV-1 Development and characterization of a human papillomavirus-based nanoparticle carrier for heterologous vaccine antigens Chronic inflammation degrades CD4 T cell immunity to prior vaccines in treated HIV infection Influence of AAV vector tropism on long-term expression and Fc-γ receptor binding of an antibody targeting SARS-CoV-2 Lectin from Triticum vulgaris (WGA) as an antiviral agent against SARS-CoV-2 Oriented display of HIV-1 Env trimers by a novel coupling strategy enhances B cell activation and phagocytosis TLR7/8 reguliert die Signalwege von Typ 1 und 3 Interferonen bei vom Rhinovirus 1b induziertem allergischen Asthma bronchiale Antigen-dependent modulation of immune responses to antigen-Fc fusion proteins by Fc-effector functions Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination Entwicklung eines schnellen, phänotypischen HIV-1 Resistenztests Propagation of SARS-CoV-2 in a Closed Cell Culture Device: Potential GMP Compatible Production Platform for Live-Attenuated Vaccine Candidates under BSL-3 Conditions? SARS-CoV-2 Spike Protein Is Capable of Inducing Cell–Cell Fusions Independent from Its Receptor ACE2 and This Activity Can Be Impaired by Furin Inhibitors or a Subset of Monoclonal Antibodies Continuous monitoring of SARS-CoV-2 seroprevalence in children using residual blood samples from routine clinical chemistry Characterization of SARS-CoV-2 Escape Mutants to a Pair of Neutralizing Antibodies Targeting the RBD and the NTD Comparative Immunogenicity of COVID-19 Vaccines in a Population-Based Cohort Study with SARS-CoV-2-Infected and Uninfected Participants Design and Functional Characterization of HIV-1 Envelope Protein-Coupled T Helper Liposomes Smaller, Stronger, More Stable: Peptide Variants of a SARS-CoV-2 Neutralizing Miniprotein Time Trend in SARS-CoV-2 Seropositivity, Surveillance Detection- and Infection Fatality Ratio until Spring 2021 in the Tirschenreuth County—Results from a Population-Based Longitudinal Study in Germany A pair of noncompeting neutralizing human monoclonal antibodies protecting from disease in a SARS‐CoV‐2 infection model Successful treatment of COVID‐19 infection with convalescent plasma in B‐cell‐depleted patients may promote cellular immunity Upregulation of CCR4 in activated CD8 + T cells indicates enhanced lung homing in patients with severe acute SARS‐CoV‐2 infection A pair of noncompeting neutralizing human monoclonal antibodies protecting from disease in a SARS-CoV-2 infection model Cloning of a Passage-Free SARS-CoV-2 Genome and Mutagenesis Using Red Recombination Complement Activation in Kidneys of Patients With COVID-19 Estimates and Determinants of SARS-Cov-2 Seroprevalence and Infection Fatality Ratio Using Latent Class Analysis: The Population-Based Tirschenreuth Study in the Hardest-Hit German County in Spring 2020 Methodological Development of a Multi-Readout Assay for the Assessment of Antiviral Drugs against SARS-CoV-2 Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization Rapid response flow cytometric assay for the detection of antibody responses to SARS-CoV-2 SARS-CoV-2-Seronegative Subjects Target CTL Epitopes in the SARS-CoV-2 Nucleoprotein Cross-Reactive to Common Cold Coronaviruses Spectrum Bias and Individual Strengths of SARS-CoV-2 Serological Tests—A Population-Based Evaluation The HIV 5′ Gag Region Displays a Specific Nucleotide Bias Regulating Viral Splicing and Infectivity Rapid response flow cytometric assay for the detection of antibody responses to SARS-CoV-2 CD4+ T Cells Induced by Tuberculosis Subunit Vaccine H1 Can Improve the HIV-1 Env Humoral Response by Intrastructural Help Conjugation of Native-Like HIV-1 Envelope Trimers onto Liposomes Using EDC/Sulfo-NHS Chemistry: Requirements and Limitations Genetic Co-Administration of Soluble PD-1 Ectodomains Modifies Immune Responses against Influenza A Virus Induced by DNA Vaccination IMU-838, a developmental DHODH inhibitor in phase II for autoimmune disease, shows anti-SARS-CoV-2 and broad-spectrum antiviral efficacy in vitro IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro Modulation of Vaccine-Induced HIV-1-Specific Immune Responses by Co-Electroporation of PD-L1 Encoding DNA Calcium Phosphate Nanoparticle-Based Vaccines as a Platform for Improvement of HIV-1 Env Antibody Responses by Intrastructural Help Electrostatically Driven Encapsulation of Hydrophilic, Non-Conformational Peptide Epitopes into Liposomes Glycosylation of HIV Env Impacts IgG Subtype Responses to Vaccination Application of the PAMONO-Sensor for Quantiﬁcation of Microvesicles and Determination of Nano-Particle Size Distribution The PAMONO-Sensor Enables Quantification of Individual Microvesicles and Estimation of Nanoparticle Size Distribution The potential of nanoparticles for the immunization against viral infections Divergence of primary cognate B- and T-cell proliferative responses to subcutaneous and intravenous immunization with virus-like particles Erratum to: GagPol-specific CD4+T-cells increase the antibody response to Env by intrastructural help GagPol-specific CD4+T-cells increase the antibody response to Env by intrastructural help Protective efficacy and immunogenicity of a combinatory DNA vaccine against influenza A virus and the respiratory syncytial virus T cell independent secondary antibody responses to the envelope protein of simian immunodeficiency virus Immunogenicity of DNA vaccines encoding simian immunodeficiency virus antigen targeted to dendritic cells in rhesus macaques Targeting antibody responses to the membrane proximal external region of the envelope glycoprotein of human immunodeficiency virus Targeting antibody responses to the membrane proximal external region of the envelope glycoprotein of human immunodeficiency virus The HIV-1 Rev protein enhances encapsidation of unspliced and spliced, RRE-containing lentiviral vector RNA Improved vaccine protection against retrovirus infection after co-administration of adenoviral vectors encoding viral antigens and type I interferon subtypes Unintended spread of a biosafety level 2 recombinant retrovirus Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligands Role of complement and antibodies in controlling infection with pathogenic simian immunodeficiency virus (SIV) in macaques vaccinated with replication-deficient viral vectors Coexpression of GM-CSF and antigen in DNA prime-adenoviral vector boost immunization enhances polyfunctional CD8+ T cell responses, whereas expression of GM-CSF antigen fusion protein induces autoimmunity Expression of RNA virus proteins by RNA polymerase II dependent expression plasmids is hindered at multiple steps Rev proteins of human and simian immunodeficiency virus enhance RNA encapsidation

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Katalog der Deutschen Nationalbibliothek

Klaus Thomas Überla

Contribution of Fc-Effector Mechanisms to the Immunogenicity of Fc-Fusion Proteins and to the Efficacy of Passive Immunization Strategies Against HIV-1

Development and characterization of a human papillomavirus-based nanoparticle carrier for heterologous vaccine antigens

Chronic inflammation degrades CD4 T cell immunity to prior vaccines in treated HIV infection

Influence of AAV vector tropism on long-term expression and Fc-γ receptor binding of an antibody targeting SARS-CoV-2

Lectin from Triticum vulgaris (WGA) as an antiviral agent against SARS-CoV-2

Oriented display of HIV-1 Env trimers by a novel coupling strategy enhances B cell activation and phagocytosis

TLR7/8 reguliert die Signalwege von Typ 1 und 3 Interferonen bei vom Rhinovirus 1b induziertem allergischen Asthma bronchiale

Antigen-dependent modulation of immune responses to antigen-Fc fusion proteins by Fc-effector functions

Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination

Entwicklung eines schnellen, phänotypischen HIV-1 Resistenztests

Propagation of SARS-CoV-2 in a Closed Cell Culture Device: Potential GMP Compatible Production Platform for Live-Attenuated Vaccine Candidates under BSL-3 Conditions?

SARS-CoV-2 Spike Protein Is Capable of Inducing Cell–Cell Fusions Independent from Its Receptor ACE2 and This Activity Can Be Impaired by Furin Inhibitors or a Subset of Monoclonal Antibodies

Continuous monitoring of SARS-CoV-2 seroprevalence in children using residual blood samples from routine clinical chemistry

Characterization of SARS-CoV-2 Escape Mutants to a Pair of Neutralizing Antibodies Targeting the RBD and the NTD

Comparative Immunogenicity of COVID-19 Vaccines in a Population-Based Cohort Study with SARS-CoV-2-Infected and Uninfected Participants

Design and Functional Characterization of HIV-1 Envelope Protein-Coupled T Helper Liposomes

Smaller, Stronger, More Stable: Peptide Variants of a SARS-CoV-2 Neutralizing Miniprotein

Time Trend in SARS-CoV-2 Seropositivity, Surveillance Detection- and Infection Fatality Ratio until Spring 2021 in the Tirschenreuth County—Results from a Population-Based Longitudinal Study in Germany

A pair of noncompeting neutralizing human monoclonal antibodies protecting from disease in a SARS‐CoV‐2 infection model

Successful treatment of COVID‐19 infection with convalescent plasma in B‐cell‐depleted patients may promote cellular immunity

Upregulation of CCR4 in activated CD8 + T cells indicates enhanced lung homing in patients with severe acute SARS‐CoV‐2 infection

A pair of noncompeting neutralizing human monoclonal antibodies protecting from disease in a SARS-CoV-2 infection model

Cloning of a Passage-Free SARS-CoV-2 Genome and Mutagenesis Using Red Recombination

Complement Activation in Kidneys of Patients With COVID-19

Estimates and Determinants of SARS-Cov-2 Seroprevalence and Infection Fatality Ratio Using Latent Class Analysis: The Population-Based Tirschenreuth Study in the Hardest-Hit German County in Spring 2020

Methodological Development of a Multi-Readout Assay for the Assessment of Antiviral Drugs against SARS-CoV-2

Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization

Rapid response flow cytometric assay for the detection of antibody responses to SARS-CoV-2

SARS-CoV-2-Seronegative Subjects Target CTL Epitopes in the SARS-CoV-2 Nucleoprotein Cross-Reactive to Common Cold Coronaviruses

Spectrum Bias and Individual Strengths of SARS-CoV-2 Serological Tests—A Population-Based Evaluation

The HIV 5′ Gag Region Displays a Specific Nucleotide Bias Regulating Viral Splicing and Infectivity

Rapid response flow cytometric assay for the detection of antibody responses to SARS-CoV-2

CD4+ T Cells Induced by Tuberculosis Subunit Vaccine H1 Can Improve the HIV-1 Env Humoral Response by Intrastructural Help

Conjugation of Native-Like HIV-1 Envelope Trimers onto Liposomes Using EDC/Sulfo-NHS Chemistry: Requirements and Limitations

Genetic Co-Administration of Soluble PD-1 Ectodomains Modifies Immune Responses against Influenza A Virus Induced by DNA Vaccination

IMU-838, a developmental DHODH inhibitor in phase II for autoimmune disease, shows anti-SARS-CoV-2 and broad-spectrum antiviral efficacy in vitro

IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro

Modulation of Vaccine-Induced HIV-1-Specific Immune Responses by Co-Electroporation of PD-L1 Encoding DNA

Calcium Phosphate Nanoparticle-Based Vaccines as a Platform for Improvement of HIV-1 Env Antibody Responses by Intrastructural Help

Electrostatically Driven Encapsulation of Hydrophilic, Non-Conformational Peptide Epitopes into Liposomes

Glycosylation of HIV Env Impacts IgG Subtype Responses to Vaccination

Application of the PAMONO-Sensor for Quantiﬁcation of Microvesicles and Determination of Nano-Particle Size Distribution

The PAMONO-Sensor Enables Quantification of Individual Microvesicles and Estimation of Nanoparticle Size Distribution

The potential of nanoparticles for the immunization against viral infections

Divergence of primary cognate B- and T-cell proliferative responses to subcutaneous and intravenous immunization with virus-like particles

Erratum to: GagPol-specific CD4+T-cells increase the antibody response to Env by intrastructural help

GagPol-specific CD4+T-cells increase the antibody response to Env by intrastructural help

Protective efficacy and immunogenicity of a combinatory DNA vaccine against influenza A virus and the respiratory syncytial virus

T cell independent secondary antibody responses to the envelope protein of simian immunodeficiency virus

Immunogenicity of DNA vaccines encoding simian immunodeficiency virus antigen targeted to dendritic cells in rhesus macaques

Targeting antibody responses to the membrane proximal external region of the envelope glycoprotein of human immunodeficiency virus

Targeting antibody responses to the membrane proximal external region of the envelope glycoprotein of human immunodeficiency virus

The HIV-1 Rev protein enhances encapsidation of unspliced and spliced, RRE-containing lentiviral vector RNA

Improved vaccine protection against retrovirus infection after co-administration of adenoviral vectors encoding viral antigens and type I interferon subtypes

Unintended spread of a biosafety level 2 recombinant retrovirus

Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligands

Role of complement and antibodies in controlling infection with pathogenic simian immunodeficiency virus (SIV) in macaques vaccinated with replication-deficient viral vectors

Coexpression of GM-CSF and antigen in DNA prime-adenoviral vector boost immunization enhances polyfunctional CD8+ T cell responses, whereas expression of GM-CSF antigen fusion protein induces autoimmunity

Expression of RNA virus proteins by RNA polymerase II dependent expression plasmids is hindered at multiple steps

Rev proteins of human and simian immunodeficiency virus enhance RNA encapsidation